TCHP

Gene Symbol TCHP
Entrez Gene 84260
Alt Symbol TpMs
Species Human
Gene Type protein-coding
Description trichoplein, keratin filament binding
Other Description mitochondrial protein with oncostatic activity|mitostatin|trichoplein keratin filament-binding protein|tumor suppressor protein
Swissprots Q9BT92 Q8NAG0
Accessions CAP07553 CAP11522 CAR97137 CAT82435 EAW97883 EAW97884 Q9BT92 AK000079 AK092736 BAC03960 AK301262 BAG62828 AY007230 AAG12971 AY210413 BC004285 AAH04285 BC022838 BX648596 EU176406 ABW03857 EU176751 ABW03552 HG505165 XM_011538836 XP_011537138 XM_011538837 XP_011537139 NM_001143852 NP_001137324 NM_032300 NP_115676
Function Tumor suppressor which has the ability to inhibit cell growth and be pro-apoptotic during cell stress. Inhibits cell growth in bladder and prostate cancer cells by a down-regulation of HSPB1 by inhibiting its phosphorylation. May act as a 'capping' or 'branching' protein for keratin filaments in the cell periphery. May regulate K8/K18 filament and desmosome organization mainly at the apical or peripheral regions of simple epithelial cells. {ECO:0000269|PubMed:15731013, ECO:0000269|PubMed:18931701}.
Subcellular Location Cytoplasm, cytoskeleton. Cytoplasm. Cell membrane. Mitochondrion.
Tissue Specificity Expressed at high levels in normal urothelial and breast epithelial cells. Also expressed in the smooth muscle and endothelial cells. Reduced expression seen in advanced bladder and breast carcinomas (at protein level). Ubiquitous. Expressed at highest levels in the heart, skeletal muscle, kidney, liver and testis. {ECO:0000269|PubMed:18931701}.

trichoplein (C-20) - sc-139293 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
trichoplein (C-20): sc-139293. Western blot analysis of trichoplein expression in Caco-2 (A), K-562 (B) and Daudi (C) whole cell lysates.

trichoplein (E-14) - sc-139294 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
trichoplein (E-14): sc-139294. Western blot analysis of trichoplein expression in K-562 whole cell lysate.

trichoplein (H-108) - sc-368860 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

trichoplein (M-17) - sc-139295 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-TCHP antibody - ab77622 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-TCHP antibody (ab77622) at 1 µg/mlLane 1 : Tonsil (Human) Whole Cell Lysate - adult normal tissue (ab29615)Lane 2 : U-87 MG (Human glioblastoma astrocytoma) Whole Cell LysateLysates/proteins at 10 µg per lane.SecondaryGoat Anti-Rabbit IgG H&L (HRP) preadsorbed (ab97080) at 1/5000 dilution

Anti-TCHP antibody - ab102638 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-TCHP antibody (ab102638) at 1/100 dilution + CEM cell lysate at 35 µg

Anti-TCHP Antibody (aa291-320, APC) - LS-C271210 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TCHP Antibody (aa291-320, AP) - LS-C271211 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TCHP Antibody (aa291-320, Biotin) - LS-C271212 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TCHP Antibody (aa291-320, FITC) - LS-C271213 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TCHP Antibody (aa291-320, Azide-free, HRP) - LS-C271214 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TCHP Antibody (aa291-320, PE) - LS-C271215 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TCHP Antibody (aa306-370) - LS-C325644 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TCHP Antibody (aa387-436) - LS-C135812 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
TCHP antibody LS-C135812 Western blot of Fetal Liver lysate.

Anti-TCHP Antibody (aa291-320) - LS-C161775 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Formalin-fixed and paraffin-embedded human skin tissue reacted with TCHP Antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.

TCHP Antibody - NBP1-89572 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: TCHP Antibody [NBP1-89572] - Lane 1: Marker [kDa] 250, 130, 95, 72, 55, 36, 28, 17, 10. Lane 2: Human cell line RT-4. Lane 3: Human cell line U-251MG sp

TCHP Antibody - NBP1-91509 from Novus Biologicals

Prices $369.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western Blot: TCHP Antibody [NBP1-91509] - Titration: 0.2-1 ug/ml, Positive Control: Human Liver.

TCHP Polyclonal Antibody - bs-6113R from Bioss

Prices $269.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

ANTI-TCHP (CENTER) antibody produced in rabbit - SAB1302957 from Sigma-Aldrich

Prices $326.50
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-TCHP antibody produced in rabbit - HPA038638 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-TCHP: <B>Cat. No. HPA038638</B>: Immunohistochemical staining of human liver shows distinct membranous positivity in hepatocytes.

TCHP antibody - C-terminal region (ARP60515_P050) - ARP60515_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

TCHP-Antibody-Center - AP9354c from Abgent, a WuXi AppTec company

Prices $99.00, $295.00
Sizes 80 µl, 400 µl
Host Rabbit
Clonality Polyclonal
Western blot analysis of TCHP Antibody (Center) (Cat. #AP9354c) in CEM cell line lysates (35ug/lane). TCHP (arrow) was detected using the purified Pab.

TCHP Antibody - middle region (OAAB05947) - OAAB05947 from Aviva Systems Biology

Prices $289.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal

TCHP antibody - orb100712 from Biorbyt

Prices $255.00, $340.00
Sizes 100 μg, 200 μg
Host Rabbit
Clonality Polyclonal

TCHP antibody - 70R-10097 from Fitzgerald

Prices $345.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
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