Gene Symbol | TCHP |
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Entrez Gene | 84260 |
Alt Symbol | TpMs |
Species | Human |
Gene Type | protein-coding |
Description | trichoplein, keratin filament binding |
Other Description | mitochondrial protein with oncostatic activity|mitostatin|trichoplein keratin filament-binding protein|tumor suppressor protein |
Swissprots | Q9BT92 Q8NAG0 |
Accessions | CAP07553 CAP11522 CAR97137 CAT82435 EAW97883 EAW97884 Q9BT92 AK000079 AK092736 BAC03960 AK301262 BAG62828 AY007230 AAG12971 AY210413 BC004285 AAH04285 BC022838 BX648596 EU176406 ABW03857 EU176751 ABW03552 HG505165 XM_011538836 XP_011537138 XM_011538837 XP_011537139 NM_001143852 NP_001137324 NM_032300 NP_115676 |
Function | Tumor suppressor which has the ability to inhibit cell growth and be pro-apoptotic during cell stress. Inhibits cell growth in bladder and prostate cancer cells by a down-regulation of HSPB1 by inhibiting its phosphorylation. May act as a 'capping' or 'branching' protein for keratin filaments in the cell periphery. May regulate K8/K18 filament and desmosome organization mainly at the apical or peripheral regions of simple epithelial cells. {ECO:0000269|PubMed:15731013, ECO:0000269|PubMed:18931701}. |
Subcellular Location | Cytoplasm, cytoskeleton. Cytoplasm. Cell membrane. Mitochondrion. |
Tissue Specificity | Expressed at high levels in normal urothelial and breast epithelial cells. Also expressed in the smooth muscle and endothelial cells. Reduced expression seen in advanced bladder and breast carcinomas (at protein level). Ubiquitous. Expressed at highest levels in the heart, skeletal muscle, kidney, liver and testis. {ECO:0000269|PubMed:18931701}. |
trichoplein CRISPR/Cas9 KO Plasmid (h) - sc-407983 from Santa Cruz Biotechnology
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trichoplein HDR Plasmid (h) - sc-407983-HDR from Santa Cruz Biotechnology
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trichoplein Double Nickase Plasmid (h) - sc-407983-NIC from Santa Cruz Biotechnology
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trichoplein Double Nickase Plasmid (h2) - sc-407983-NIC-2 from Santa Cruz Biotechnology
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trichoplein CRISPR Activation Plasmid (h) - sc-407983-ACT from Santa Cruz Biotechnology
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trichoplein CRISPR Activation Plasmid (h2) - sc-407983-ACT-2 from Santa Cruz Biotechnology
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trichoplein Lentiviral Activation Particles (h) - sc-407983-LAC from Santa Cruz Biotechnology
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trichoplein Lentiviral Activation Particles (h2) - sc-407983-LAC-2 from Santa Cruz Biotechnology
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trichoplein siRNA (h) - sc-95954 from Santa Cruz Biotechnology
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trichoplein shRNA Plasmid (h) - sc-95954-SH from Santa Cruz Biotechnology
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trichoplein shRNA (h) Lentiviral Particles - sc-95954-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU139871 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN21154 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND21154 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR09190 from Sigma-Aldrich
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TCHP siRNA (Human) - CRJ3386 from Cohesion Biosciences
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TCHP - MBS8203656 from MyBioSource
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shRNA set against Human TCHP (NM_032300.4) - SHH424948 from Creative biogene
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TCHP shRNA Plasmid (Human) - CHJ3386 from Cohesion Biosciences
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TCHP miRNA 3'UTR clone - MiUTR3H-12524 from Creative biogene
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TCHP miRNA 3'UTR clone - MiUTR3H-12525 from Creative biogene
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