TCHP

Gene Symbol TCHP
Entrez Gene 84260
Alt Symbol TpMs
Species Human
Gene Type protein-coding
Description trichoplein, keratin filament binding
Other Description mitochondrial protein with oncostatic activity|mitostatin|trichoplein keratin filament-binding protein|tumor suppressor protein
Swissprots Q9BT92 Q8NAG0
Accessions CAP07553 CAP11522 CAR97137 CAT82435 EAW97883 EAW97884 Q9BT92 AK000079 AK092736 BAC03960 AK301262 BAG62828 AY007230 AAG12971 AY210413 BC004285 AAH04285 BC022838 BX648596 EU176406 ABW03857 EU176751 ABW03552 HG505165 XM_011538836 XP_011537138 XM_011538837 XP_011537139 NM_001143852 NP_001137324 NM_032300 NP_115676
Function Tumor suppressor which has the ability to inhibit cell growth and be pro-apoptotic during cell stress. Inhibits cell growth in bladder and prostate cancer cells by a down-regulation of HSPB1 by inhibiting its phosphorylation. May act as a 'capping' or 'branching' protein for keratin filaments in the cell periphery. May regulate K8/K18 filament and desmosome organization mainly at the apical or peripheral regions of simple epithelial cells. {ECO:0000269|PubMed:15731013, ECO:0000269|PubMed:18931701}.
Subcellular Location Cytoplasm, cytoskeleton. Cytoplasm. Cell membrane. Mitochondrion.
Tissue Specificity Expressed at high levels in normal urothelial and breast epithelial cells. Also expressed in the smooth muscle and endothelial cells. Reduced expression seen in advanced bladder and breast carcinomas (at protein level). Ubiquitous. Expressed at highest levels in the heart, skeletal muscle, kidney, liver and testis. {ECO:0000269|PubMed:18931701}.

Human-TCHP-cDNA-Clone - DC01441 from Abgent, a WuXi AppTec company

Prices $672.30
Sizes 10 µg
Species Human
Accession BC004285

TCHP - MBS1274271 from MyBioSource

Prices $175.00
Sizes 10ug plasmid + 200ul glycerol stock
Species Human
Accession BC004285

Human TCHP cDNA clone(NM_001143852.1) - CDFH019368 from Creative Biomart

Species Human
Accession NM_001143852.1

Human TCHP ORF Clone(NM_032300.4) - CDCL178103 from Creative Biomart

Species Human
Accession NM_032300.4

Human TCHP ORF Clone(NM_001143852.1) - CDCR351866 from Creative Biomart

Species Human
Accession NM_001143852.1

Human TCHP ORF Clone(NM_001143852.1) - CDCR351867 from Creative Biomart

Species Human
Accession NM_001143852.1

human TCHP ORF clone - CDCH089800 from Creative Biomart

Species Human
Accession NM_001143852

human TCHP ORF clone - CDCH089801 from Creative Biomart

Species Human
Accession NM_001143852

Human TCHP ORF Clone(NM_001143852.1) - CDCR351866 from Creative biogene

Species Human

Human TCHP ORF Clone (BC004285) - CDCS408359 from Creative biogene

Species Human
Accession Q9BT92

Human TCHP ORF clone (BC004285) - CDCB158705 from Creative biogene

Species Human

Human TCHP cDNA Clone(NM_001143852.1) - CDFH019368 from Creative biogene

Species Human
Search more