TCHP

Gene Symbol	TCHP
Entrez Gene	84260
Alt Symbol	TpMs
Species	Human
Gene Type	protein-coding
Description	trichoplein, keratin filament binding
Other Description	mitochondrial protein with oncostatic activity|mitostatin|trichoplein keratin filament-binding protein|tumor suppressor protein
Swissprots	Q9BT92 Q8NAG0
Accessions	CAP07553 CAP11522 CAR97137 CAT82435 EAW97883 EAW97884 Q9BT92 AK000079 AK092736 BAC03960 AK301262 BAG62828 AY007230 AAG12971 AY210413 BC004285 AAH04285 BC022838 BX648596 EU176406 ABW03857 EU176751 ABW03552 HG505165 XM_011538836 XP_011537138 XM_011538837 XP_011537139 NM_001143852 NP_001137324 NM_032300 NP_115676
Function	Tumor suppressor which has the ability to inhibit cell growth and be pro-apoptotic during cell stress. Inhibits cell growth in bladder and prostate cancer cells by a down-regulation of HSPB1 by inhibiting its phosphorylation. May act as a 'capping' or 'branching' protein for keratin filaments in the cell periphery. May regulate K8/K18 filament and desmosome organization mainly at the apical or peripheral regions of simple epithelial cells. {ECO:0000269|PubMed:15731013, ECO:0000269|PubMed:18931701}.
Subcellular Location	Cytoplasm, cytoskeleton. Cytoplasm. Cell membrane. Mitochondrion.
Tissue Specificity	Expressed at high levels in normal urothelial and breast epithelial cells. Also expressed in the smooth muscle and endothelial cells. Reduced expression seen in advanced bladder and breast carcinomas (at protein level). Ubiquitous. Expressed at highest levels in the heart, skeletal muscle, kidney, liver and testis. {ECO:0000269|PubMed:18931701}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human TCHP peptide - ab91616 from Abcam Category Peptide

TCHP Antibody Blocking Peptide - LS-E22146 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

TCHP Antibody Blocking Peptide - LS-E10082 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

TCHP-Antibody-Center-Blocking-Peptide - BP9354c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

TCHP Blocking Peptide - 33R-4111 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

TCHP fusion protein - ag8109 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

TCHP fusion protein - Ag23199 from Proteintech Group Category Protein Source E. coli -derived, PET30a Species Human

Recombinant Human Trichoplein keratin filament-binding protein(TCHP) - CSB-YP874804HU CSB-EP874804HU CSB-BP874804HU CSB-MP874804HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

TCHP Recombinant Protein Antigen - NBP1-89572PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

TCHP Recombinant Protein Antigen - NBP2-49340PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E. coli Species Human

TCHP Peptide, Human - M34GP15733H from Creative Peptides Category Peptide Source Synthetic. Species Human

TCHP Recombinant Protein (OPCA02496) - OPCA02496 from Aviva Systems Biology Category Protein Prices $250.00 Sizes 50 µg Source Human

Recombinant human Trichoplein keratin filament-binding protein - AP71561 from Signalway Antibody Category Protein Prices $260.00, $735.00, $1,240.00, $1,975.00 Sizes 50 µg, 200 µg, 500 µg, 1 mg Source E.coli Species Human

Recombinant Human TCHP Protein (1-498 aa), His-SUMO-tagged - TCHP-1134H from Creative Biomart Category Protein Source E. coli Species Human

Search more