TCHP

Gene Symbol	TCHP
Entrez Gene	84260
Alt Symbol	TpMs
Species	Human
Gene Type	protein-coding
Description	trichoplein, keratin filament binding
Other Description	mitochondrial protein with oncostatic activity|mitostatin|trichoplein keratin filament-binding protein|tumor suppressor protein
Swissprots	Q9BT92 Q8NAG0
Accessions	CAP07553 CAP11522 CAR97137 CAT82435 EAW97883 EAW97884 Q9BT92 AK000079 AK092736 BAC03960 AK301262 BAG62828 AY007230 AAG12971 AY210413 BC004285 AAH04285 BC022838 BX648596 EU176406 ABW03857 EU176751 ABW03552 HG505165 XM_011538836 XP_011537138 XM_011538837 XP_011537139 NM_001143852 NP_001137324 NM_032300 NP_115676
Function	Tumor suppressor which has the ability to inhibit cell growth and be pro-apoptotic during cell stress. Inhibits cell growth in bladder and prostate cancer cells by a down-regulation of HSPB1 by inhibiting its phosphorylation. May act as a 'capping' or 'branching' protein for keratin filaments in the cell periphery. May regulate K8/K18 filament and desmosome organization mainly at the apical or peripheral regions of simple epithelial cells. {ECO:0000269|PubMed:15731013, ECO:0000269|PubMed:18931701}.
Subcellular Location	Cytoplasm, cytoskeleton. Cytoplasm. Cell membrane. Mitochondrion.
Tissue Specificity	Expressed at high levels in normal urothelial and breast epithelial cells. Also expressed in the smooth muscle and endothelial cells. Reduced expression seen in advanced bladder and breast carcinomas (at protein level). Ubiquitous. Expressed at highest levels in the heart, skeletal muscle, kidney, liver and testis. {ECO:0000269|PubMed:18931701}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Trichoplein keratin filament-binding protein (TCHP), Human, ELISA Kit - CSB-EL023311HU from ARP American Research Products Category ELISA Kit Prices $495.00, $695.00, $696.00, $699.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t

trichoplein, keratin filament binding, ELISA Kit - MBS908453 from MyBioSource Category ELISA Kit Prices $250.00, $495.00, $710.00, $2,705.00, $5,145.00 Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity The minimum detectable dose of human TCHP is typically less than 6.25 pg/ml. The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined the mean O.D value of 20 replicates of the zero standard added by their three standard deviations. Range 25 pg/ml-1600 pg/ml.

Human Trichoplein keratin filament-binding protein(TCHP) ELISA kit - CSB-EL023311HU from Cusabio Category ELISA Kit Sensitivity 6.25 pg/ml Range 25 pg/ml-1600 pg/ml

Human TCHP ELISA Kit - E039433 from Biobool Category ELISA Kit Sensitivity The minimum detectable dose of human TCHP is typically less than 6.25 pg/ml. The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined the mea

TCHP ELISA Kit (Human) (OKCA01562) - OKCA01562 from Aviva Systems Biology Category ELISA Kit Prices $600.00 Sizes 96 wells Sensitivity 6.25 pg/mL Range 25 - 1,600 pg/mL

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