TCHP

Gene Symbol TCHP
Entrez Gene 84260
Alt Symbol TpMs
Species Human
Gene Type protein-coding
Description trichoplein, keratin filament binding
Other Description mitochondrial protein with oncostatic activity|mitostatin|trichoplein keratin filament-binding protein|tumor suppressor protein
Swissprots Q9BT92 Q8NAG0
Accessions CAP07553 CAP11522 CAR97137 CAT82435 EAW97883 EAW97884 Q9BT92 AK000079 AK092736 BAC03960 AK301262 BAG62828 AY007230 AAG12971 AY210413 BC004285 AAH04285 BC022838 BX648596 EU176406 ABW03857 EU176751 ABW03552 HG505165 XM_011538836 XP_011537138 XM_011538837 XP_011537139 NM_001143852 NP_001137324 NM_032300 NP_115676
Function Tumor suppressor which has the ability to inhibit cell growth and be pro-apoptotic during cell stress. Inhibits cell growth in bladder and prostate cancer cells by a down-regulation of HSPB1 by inhibiting its phosphorylation. May act as a 'capping' or 'branching' protein for keratin filaments in the cell periphery. May regulate K8/K18 filament and desmosome organization mainly at the apical or peripheral regions of simple epithelial cells. {ECO:0000269|PubMed:15731013, ECO:0000269|PubMed:18931701}.
Subcellular Location Cytoplasm, cytoskeleton. Cytoplasm. Cell membrane. Mitochondrion.
Tissue Specificity Expressed at high levels in normal urothelial and breast epithelial cells. Also expressed in the smooth muscle and endothelial cells. Reduced expression seen in advanced bladder and breast carcinomas (at protein level). Ubiquitous. Expressed at highest levels in the heart, skeletal muscle, kidney, liver and testis. {ECO:0000269|PubMed:18931701}.

TCHP-Over-expression-Lysate - LY15345a from Abgent, a WuXi AppTec company

Category Cell Lysate
Prices $325.00
Sizes 100 µg
Western blot analysis of his-tag TCHP (arrow) using his tag antibody. 293 cell lysates (2 ug/lane) either nontransfected (Lane 2) or transiently transfected with theTCHP gene

TCHP Overexpression Lysate (Native) - NBP2-06052 from Novus Biologicals

Category Cell Lysate
Prices $329.00
Sizes 100 µg
Western Blot: TCHP Overexpression Lysate (Adult Normal) [NBP2-06052] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for TCHP.

TCHP Overexpression Lysate (Native) - NBP2-09696 from Novus Biologicals

Category Cell Lysate
Prices $329.00
Sizes 100 µg
Western Blot: TCHP Overexpression Lysate (Adult Normal) [NBP2-09696] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for TCHP.

Panoply™ Human TCHP Knockdown Stable Cell Line - CSC-DC015733 from Creative biogene

Category Cell Line
Species Human
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