OAS2

Gene Symbol	OAS2
Entrez Gene	4939
Alt Symbol	-
Species	Human
Gene Type	protein-coding
Description	2'-5'-oligoadenylate synthetase 2, 69/71kDa
Other Description	(2'-5')oligo(A) synthetase 2|2'-5'-oligoadenylate synthase 2|2-5A synthase 2|p69 OAS / p71 OAS
Swissprots	A8K9T1 Q86XX8 P29728 Q6PJ33
Accessions	EAW98026 EAW98027 P29728 AF074990 AK292796 BAF85485 AK292906 BAF85595 BC010625 AAH10625 BC023637 AAH23637 BC049215 AAH49215 BC053870 AAH53870 BC069052 AAH69052 BE885222 BQ213828 M87284 AAA60606 M87434 AAA60607 XM_011538415 XP_011536717 NM_001032731 NP_001027903 NM_002535 NP_002526 NM_016817 NP_058197
Function	Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes higher oligomers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L. {ECO:0000269|PubMed:10464285, ECO:0000269|PubMed:19923450, ECO:0000269|PubMed:9880569}.
Subcellular Location	Cytoplasm. Cytoplasm, perinuclear region. Mitochondrion. Nucleus. Microsome. Endoplasmic reticulum. Note=Associated with different subcellular fractions such as mitochondrial, nuclear, and rough/smooth microsomal fractions.
Top Pathways	Hepatitis C, Measles, Influenza A, Herpes simplex infection

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human OAS2 ELISA Kit (Sandwich ELISA) - LS-F8120 from LifeSpan Bioscience Category ELISA Kit Prices $720.00 Sizes 1 plate Sensitivity 0.78 ng/ml Range 0.78-50 ng/ml

Human OAS2 ELISA Kit - abx152574 from Abbexa Category ELISA Kit Sensitivity 1.24 ng/ml Range 3.125 ng/ml - 200 ng/ml

2',5'-Oligoadenylate Synthetase 2 (OAS2), Human, ELISA Kit - SEF689Hu from ARP American Research Products Category ELISA Kit Prices $720.00 Sizes 96 t Sensitivity 1.24ng/mL Range 3.12-200ng/mL

2'-5'-oligoadenylate synthase 2, OAS2, Human, ELISA Kit - E0722h from ARP American Research Products Category ELISA Kit Prices $596.00 Sizes 96 t Range 0.312-20 ng/mL

ELISA Kit for 2',5'-Oligoadenylate Synthetase 2 (OAS2) - SEF689Hu from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.36ng/mL. Range 0.781-50ng/mL The standard curve concentrations used for the ELISA’s were 50ng/mL, 25ng/mL, 12.5ng/mL, 6.25ng/mL, 3.125ng/mL, 1.563ng/mL, 0.781ng/mL

ELISA Kit for 2',5'-Oligoadenylate Synthetase 2 (OAS2) - SEF689Hu from Cloud-clone Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.36ng/mL. Range 0.781-50ng/mL The standard curve concentrations used for the ELISA's were 50ng/mL, 25ng/mL, 12.5ng/mL, 6.25ng/mL, 3.125ng/mL, 1.563ng/mL, 0.781ng/mL

Human OAS2 ELISA Kit (Custom ELISA) - LS-F15109 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity To be determined Range 0.78-50 ng/ml

Human 2'-5'-oligoadenylate synthase 2 ELISA Kit - abx250264 from Abbexa Category ELISA Kit Range 0.312 ng/ml - 20 ng/ml

2,5-Oligoadenylate Synthetase 2 (OAS2), Human, ELISA Kit - DL-OAS2-Hu from ARP American Research Products Category ELISA Kit Prices $655.00 Sizes 96 t Range 3.12-200 ng/mL

Human OAS2 ELISA Kit - orb369592 from Biorbyt Category ELISA Kit Prices $553.00, $621.00 Sizes 48 test, 96 test Range Detection Range: 3.125-200ng/mL Detection low threshold: 1.24ng/mL

Human OAS2 ELISA Kit - abx575311 from Abbexa Category ELISA Kit Sensitivity 1.24 ng/ml Range 3.125 ng/ml - 200 ng/ml

Human 2'-5'-oligoadenylate synthase 2 ELISA Kit - EKE53081 from Biomatik Category ELISA Kit Prices $685.40, $2,912.95, $5,483.20 Sizes 96 t, 5x96t, 10x96t Sensitivity The minimum detectable dose of this kit is typically less than 0.12 ng/mL Range 0.312-20 ng/mL

OAS2 - EKH2048 from Nordic BioSite Sensitivity 0.188ng/ml Range 0.312-20ng/ml

Human OAS2 ELISA Kit - E041792 from Biobool Category ELISA Kit Sensitivity < 37.5pg/ml

OAS2 ELISA Kit (Human) (OKEH04370) - OKEH04370 from Aviva Systems Biology Category ELISA Kit Prices $596.00 Sizes 96 wells Sensitivity < 0.15 ng/mL. Range 0.31 - 20 ng/mL

2',5'-Oligoadenylate Synthetase 2 (OAS2), ELISA Kit - MBS451614 from MyBioSource Category ELISA Kit Prices $415.00, $550.00, $2,425.00, $4,710.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 1.24ng/mL Range 3.125-200ng/mL

2'-5'-oligoadenylate synthase 2, ELISA Kit - MBS2887104 from MyBioSource Category ELISA Kit Prices $380.00, $500.00, $2,170.00, $3,840.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Range 0.312-20 ng/mL

Human OAS2 ELISA Kit (Competitive EIA) - LS-F39175 from LifeSpan Bioscience Category ELISA Kit Sensitivity 0.188 Range 0.78-50 ng/ml

Search more