OAS2
| Gene Symbol | OAS2 |
|---|---|
| Entrez Gene | 4939 |
| Alt Symbol | - |
| Species | Human |
| Gene Type | protein-coding |
| Description | 2'-5'-oligoadenylate synthetase 2, 69/71kDa |
| Other Description | (2'-5')oligo(A) synthetase 2|2'-5'-oligoadenylate synthase 2|2-5A synthase 2|p69 OAS / p71 OAS |
| Swissprots | A8K9T1 Q86XX8 P29728 Q6PJ33 |
| Accessions | EAW98026 EAW98027 P29728 AF074990 AK292796 BAF85485 AK292906 BAF85595 BC010625 AAH10625 BC023637 AAH23637 BC049215 AAH49215 BC053870 AAH53870 BC069052 AAH69052 BE885222 BQ213828 M87284 AAA60606 M87434 AAA60607 XM_011538415 XP_011536717 NM_001032731 NP_001027903 NM_002535 NP_002526 NM_016817 NP_058197 |
| Function | Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes higher oligomers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L. {ECO:0000269|PubMed:10464285, ECO:0000269|PubMed:19923450, ECO:0000269|PubMed:9880569}. |
| Subcellular Location | Cytoplasm. Cytoplasm, perinuclear region. Mitochondrion. Nucleus. Microsome. Endoplasmic reticulum. Note=Associated with different subcellular fractions such as mitochondrial, nuclear, and rough/smooth microsomal fractions. |
| Top Pathways | Hepatitis C, Measles, Influenza A, Herpes simplex infection |
OAS2 CRISPR/Cas9 KO Plasmid (h) - sc-404302 from Santa Cruz Biotechnology
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OAS2 HDR Plasmid (h) - sc-404302-HDR from Santa Cruz Biotechnology
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OAS2 Double Nickase Plasmid (h) - sc-404302-NIC from Santa Cruz Biotechnology
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OAS2 Double Nickase Plasmid (h2) - sc-404302-NIC-2 from Santa Cruz Biotechnology
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OAS2 CRISPR Activation Plasmid (h) - sc-404302-ACT from Santa Cruz Biotechnology
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OAS2 CRISPR Activation Plasmid (h2) - sc-404302-ACT-2 from Santa Cruz Biotechnology
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OAS2 Lentiviral Activation Particles (h) - sc-404302-LAC from Santa Cruz Biotechnology
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OAS2 Lentiviral Activation Particles (h2) - sc-404302-LAC-2 from Santa Cruz Biotechnology
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OAS2 siRNA (h) - sc-61243 from Santa Cruz Biotechnology
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OAS2 shRNA Plasmid (h) - sc-61243-SH from Santa Cruz Biotechnology
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OAS2 shRNA (h) Lentiviral Particles - sc-61243-V from Santa Cruz Biotechnology
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OAS2 RNAi - H00004939-R03 from Novus Biologicals
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OAS2 RNAi - H00004939-R01 from Novus Biologicals
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OAS2 RNAi - H00004939-R02 from Novus Biologicals
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MISSION® esiRNA - EHU131821 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN15664 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND15664 from Sigma-Aldrich
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OAS2 siRNA (Human) - CRH3283 from Cohesion Biosciences
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shRNA set against Human OAS2 (NM_002535.2) - SHH356976 from Creative biogene
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shRNA set against Human OAS2(NM_001032731.1) - SHR029022 from Creative biogene
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shRNA set against Human OAS2(NM_002535.2) - SHR029058 from Creative biogene
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shRNA set against Human OAS2(NM_016817.2) - SHR029108 from Creative biogene
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OAS2 shRNA Plasmid (Human) - CHH3283 from Cohesion Biosciences
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OAS2 miRNA 3'UTR clone - MiUTR1H-07018 from Creative biogene
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OAS2 miRNA 3'UTR clone - MiUTR1H-07019 from Creative biogene
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