| Gene Symbol |
OAS2
|
| Entrez Gene |
4939
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
2'-5'-oligoadenylate synthetase 2, 69/71kDa
|
| Other Description |
(2'-5')oligo(A) synthetase 2|2'-5'-oligoadenylate synthase 2|2-5A synthase 2|p69 OAS / p71 OAS
|
| Swissprots |
A8K9T1 Q86XX8 P29728 Q6PJ33
|
| Accessions |
EAW98026 EAW98027 P29728 AF074990 AK292796 BAF85485 AK292906 BAF85595 BC010625 AAH10625 BC023637 AAH23637 BC049215 AAH49215 BC053870 AAH53870 BC069052 AAH69052 BE885222 BQ213828 M87284 AAA60606 M87434 AAA60607 XM_011538415 XP_011536717 NM_001032731 NP_001027903 NM_002535 NP_002526 NM_016817 NP_058197
|
| Function |
Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes higher oligomers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L. {ECO:0000269|PubMed:10464285, ECO:0000269|PubMed:19923450, ECO:0000269|PubMed:9880569}.
|
| Subcellular Location |
Cytoplasm. Cytoplasm, perinuclear region. Mitochondrion. Nucleus. Microsome. Endoplasmic reticulum. Note=Associated with different subcellular fractions such as mitochondrial, nuclear, and rough/smooth microsomal fractions.
|
| Top Pathways |
Hepatitis C, Measles, Influenza A, Herpes simplex infection
|
![Western Blot: OAS2 Overexpression Lysate (Adult Normal) [NBL1-13897] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for OAS2.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/5545_OAS2%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-13897-img0002.jpg)