OAS2

Gene Symbol OAS2
Entrez Gene 4939
Alt Symbol -
Species Human
Gene Type protein-coding
Description 2'-5'-oligoadenylate synthetase 2, 69/71kDa
Other Description (2'-5')oligo(A) synthetase 2|2'-5'-oligoadenylate synthase 2|2-5A synthase 2|p69 OAS / p71 OAS
Swissprots A8K9T1 Q86XX8 P29728 Q6PJ33
Accessions EAW98026 EAW98027 P29728 AF074990 AK292796 BAF85485 AK292906 BAF85595 BC010625 AAH10625 BC023637 AAH23637 BC049215 AAH49215 BC053870 AAH53870 BC069052 AAH69052 BE885222 BQ213828 M87284 AAA60606 M87434 AAA60607 XM_011538415 XP_011536717 NM_001032731 NP_001027903 NM_002535 NP_002526 NM_016817 NP_058197
Function Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes higher oligomers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L. {ECO:0000269|PubMed:10464285, ECO:0000269|PubMed:19923450, ECO:0000269|PubMed:9880569}.
Subcellular Location Cytoplasm. Cytoplasm, perinuclear region. Mitochondrion. Nucleus. Microsome. Endoplasmic reticulum. Note=Associated with different subcellular fractions such as mitochondrial, nuclear, and rough/smooth microsomal fractions.
Top Pathways Hepatitis C, Measles, Influenza A, Herpes simplex infection

OAS2 (C-1) - sc-374238 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
OAS2 (C-1): sc-374238. Western blot analysis of OAS2 expression in non-transfected: sc-117752 (A) and human OAS2 transfected: sc-116044 (B) 293T whole cell lysates.

OAS2 (H-180) - sc-99097 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
OAS2 (H-180): sc-99097. Western blot analysis of OAS2 expression in Jurkat (A) and GA-10 (B) whole cell lysates.

OAS2 (G-9) - sc-271117 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
OAS2 (G-9): sc-271117. Western blot analysis of OAS2 expression in non-transfected: sc-117752 (A) and human OAS2 transfected: sc-116044 (B) 293T whole cell lysates.

OAS2 (W-16) - sc-49863 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
OAS2 (W-16): sc-49863. Western blot analysis of OAS2 expression in HeLa (A), Hep G2 (B) and BJAB (C) whole cell lysates.

Anti-OAS2 antibody - ab197655 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-OAS2 antibody (ab197655) at 1/300 dilution + mouse heart tissue lysate at 40 µg

Anti-OAS2 antibody - ab195968 from Abcam

Prices $370.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
All lanes : Anti-OAS2 antibody (ab195968) at 0.3 µg/mlLane 1 : Daudi cell lysate (in RIPA buffer)Lane 2 : Jurkat cell lysate (in RIPA buffer)Lane 3 : K562 cell lysate (in RIPA buffer)Lysates/proteins at 35 µg per lane.developed using the ECL technique

Anti-OAS2 antibody - ab90045 from Abcam

Prices $370.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-OAS2 antibody (ab90045) at 1 µg/ml (5% skim milk / PBS buffer) + SH SYSY cell lysate at 10 µgSecondaryHRP conjugated anti-Rabbit IgG at 1/50000 dilution

Anti-OAS2 antibody - ab60091 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab60091 at 1/50 - 1/100 dilution, staining OAS2 in human breast carcinoma by Immunohistochemistry, Formalin-fixed, Paraffin-embedded tissue, followed by peroxidase-conjugated secondary antibody and AEC staining.

Anti-OAS2 antibody - ab188114 from Abcam

Prices $370.00
Sizes 200 µl
Host Goat
Clonality Polyclonal
Anti-OAS2 antibody (ab188114) at 1 µg/ml (incubated for 1 hour) + Jurkat cell lysate at 35 µgdeveloped using the ECL technique

Anti-OAS2 antibody [5C3] - N-terminal - ab180403 from Abcam

Prices $357.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 5C3
All lanes : Anti-OAS2 antibody [5C3] - N-terminal (ab180403) at 1/200 dilutionLane 1 : Non-transfected HEK293T cell lysateLane 2 : OAS2 transfected HEK293T cell lysateLysates/proteins at 5 µg per lane.

Anti-OAS2 Antibody (aa713-727) - LS-C3144 from LifeSpan Bioscience

Prices $285.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-OAS2 Antibody (aa357-371) IHC-plus™ - LS-B11266 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
Anti-OAS2 antibody IHC staining of human breast. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B11266 concentration 5 ug/ml.

Anti-OAS2 Antibody (aa60-335, clone 5E1) - LS-C336695 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 5E1
IHC of paraffin-embedded Human lymphoma tissue using anti-OAS2 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120°C for 3min).

Anti-OAS2 Antibody (C-Terminus, APC) - LS-C280353 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-OAS2 Antibody (C-Terminus, AP) - LS-C280354 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-OAS2 Antibody (C-Terminus, Biotin) - LS-C280355 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-OAS2 Antibody (C-Terminus, FITC) - LS-C280356 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-OAS2 Antibody (C-Terminus, PE) - LS-C280358 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-OAS2 Antibody (C-Terminus, Azide-free, HRP) - LS-C280357 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-OAS2 Antibody (C-Terminus) - LS-C328084 from LifeSpan Bioscience

Prices $425.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-OAS2 Antibody - LS-C332484 from LifeSpan Bioscience

Prices $305.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-OAS2 Antibody (aa398-447) - LS-C80378 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Fetal lung lysate. Antibody concentration: 1.0 ug/ml. Gel concentration: 12%.

Anti-OAS2 Antibody (aa35-84) - LS-C110572 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
OAS2 antibody LS-C110572 Western blot of SH-SYSY lysate.

Anti-OAS2 Antibody (aa65-76) - LS-C305836 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
OAS2 antibody (1 ug/ml) staining of Jurkat lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Anti-OAS2 Antibody (aa60-335, clone 4B11) - LS-C336668 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 4B11
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY OAS2 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-OAS2.
Search more