| Gene Symbol | OAS2 |
|---|---|
| Entrez Gene | 4939 |
| Alt Symbol | - |
| Species | Human |
| Gene Type | protein-coding |
| Description | 2'-5'-oligoadenylate synthetase 2, 69/71kDa |
| Other Description | (2'-5')oligo(A) synthetase 2|2'-5'-oligoadenylate synthase 2|2-5A synthase 2|p69 OAS / p71 OAS |
| Swissprots | A8K9T1 Q86XX8 P29728 Q6PJ33 |
| Accessions | EAW98026 EAW98027 P29728 AF074990 AK292796 BAF85485 AK292906 BAF85595 BC010625 AAH10625 BC023637 AAH23637 BC049215 AAH49215 BC053870 AAH53870 BC069052 AAH69052 BE885222 BQ213828 M87284 AAA60606 M87434 AAA60607 XM_011538415 XP_011536717 NM_001032731 NP_001027903 NM_002535 NP_002526 NM_016817 NP_058197 |
| Function | Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes higher oligomers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L. {ECO:0000269|PubMed:10464285, ECO:0000269|PubMed:19923450, ECO:0000269|PubMed:9880569}. |
| Subcellular Location | Cytoplasm. Cytoplasm, perinuclear region. Mitochondrion. Nucleus. Microsome. Endoplasmic reticulum. Note=Associated with different subcellular fractions such as mitochondrial, nuclear, and rough/smooth microsomal fractions. |
| Top Pathways | Hepatitis C, Measles, Influenza A, Herpes simplex infection |