OAS2

Gene Symbol	OAS2
Entrez Gene	4939
Alt Symbol	-
Species	Human
Gene Type	protein-coding
Description	2'-5'-oligoadenylate synthetase 2, 69/71kDa
Other Description	(2'-5')oligo(A) synthetase 2|2'-5'-oligoadenylate synthase 2|2-5A synthase 2|p69 OAS / p71 OAS
Swissprots	A8K9T1 Q86XX8 P29728 Q6PJ33
Accessions	EAW98026 EAW98027 P29728 AF074990 AK292796 BAF85485 AK292906 BAF85595 BC010625 AAH10625 BC023637 AAH23637 BC049215 AAH49215 BC053870 AAH53870 BC069052 AAH69052 BE885222 BQ213828 M87284 AAA60606 M87434 AAA60607 XM_011538415 XP_011536717 NM_001032731 NP_001027903 NM_002535 NP_002526 NM_016817 NP_058197
Function	Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes higher oligomers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L. {ECO:0000269|PubMed:10464285, ECO:0000269|PubMed:19923450, ECO:0000269|PubMed:9880569}.
Subcellular Location	Cytoplasm. Cytoplasm, perinuclear region. Mitochondrion. Nucleus. Microsome. Endoplasmic reticulum. Note=Associated with different subcellular fractions such as mitochondrial, nuclear, and rough/smooth microsomal fractions.
Top Pathways	Hepatitis C, Measles, Influenza A, Herpes simplex infection

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human OAS2 full length protein - ab132656 from Abcam Category Protein Source Wheat germ Species Human

Human OAS2 protein fragment - ab127146 from Abcam Category Protein Source E. coli Species Human

OAS2 Antibody Blocking Peptide - LS-E14977 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

OAS2 Antibody Blocking Peptide - LS-E14976 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human OAS2 Protein - H00004939-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

OAS2 Blocking Peptide - 33R-1294 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

OAS2 Blocking Peptide - 33R-1912 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

OAS2 - H00004939-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

OAS2 - H00004939-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

OAS2 fusion protein - ag6170 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

OAS2 fusion protein - Ag5436 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

Recombinant 2',5'-Oligoadenylate Synthetase 2 (OAS2) - RPF689Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant 2',5'-Oligoadenylate Synthetase 2 (OAS2) - RPF689Hu01 from Cloud-clone Category Protein Source E.coli Species Human

OAS2 , Peptide - MBS428365 from MyBioSource Category Peptide Prices $175.00 Sizes 100 µg Species Human

OAS2 , Peptide - MBS428497 from MyBioSource Category Peptide Prices $175.00 Sizes 100 µg Species Human

OAS2-Antibody-C-term-Blocking-Peptide - BP6227a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

OAS2 Peptide, Human - M34GP10784H from Creative Peptides Category Peptide Source Synthetic. Species Human

OAS2 Recombinant Protein (OPCD05875) - OPCD05875 from Aviva Systems Biology Category Protein Source E.coli Species Human

OAS2 Recombinant Protein Antigen - NBP2-58756PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

Recombinant Human OAS2 Protein, His-tagged - OAS2-309H from Creative Biomart Category Protein Source E. coli Species Human

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