KLK7

Gene Symbol	KLK7
Entrez Gene	5650
Alt Symbol	PRSS6, SCCE, hK7
Species	Human
Gene Type	protein-coding
Description	kallikrein-related peptidase 7
Other Description	kallikrein 7 (chymotryptic, stratum corneum)|kallikrein-7|serine protease 6|signal protein|stratum corneum chymotryptic enzyme
Swissprots	A8K0U5 Q8N5N9 Q8NFV7 P49862
Accessions	AAD49718 AAG33360 AAK69624 CAA02644 CAG17626 EAW71958 EAW71959 EAW71960 EAW71961 P49862 AA101043 AF411214 AAN03662 AF411215 AAN03663 AI049783 AK289660 BAF82349 AK295313 BAG58291 AY601109 AAU04540 AY646152 AAT66047 BC032005 AAH32005 DA243628 DA307925 DQ018784 AAY97797 DQ890746 ABM81672 DQ893916 ABM84842 KF963189 AHN52223 KF963190 KF963191 KF963192 AHN52224 KF963193 L33404 AAC37551 NM_001243126 NP_001230055 NM_001207053 NP_001193982 NM_005046 NP_005037 NM_139277 NP_644806
Function	May catalyze the degradation of intercellular cohesive structures in the cornified layer of the skin in the continuous shedding of cells from the skin surface. Specific for amino acid residues with aromatic side chains in the P1 position. Cleaves insulin A chain at '14-Tyr-|-Gln-15' and insulin B chain at '6- Leu-|-Cys-7', '16-Tyr-|-Leu-17', '25-Phe-|-Tyr-26' and '26-Tyr-|- Thr-27'. Could play a role in the activation of precursors to inflammatory cytokines. {ECO:0000269|PubMed:23370777}.
Subcellular Location	Secreted {ECO:0000269|PubMed:12738725}. Note=In ovarian carcinoma, secreted and also observed at the apical membrane and in cytoplasm at the invasive front.
Tissue Specificity	Abundantly expressed in the skin and is expressed by keratinocytes in the epidermis. Also expressed in the brain, mammary gland, cerebellum, spinal cord and kidney. Lower levels in salivary glands, uterus, thymus, thyroid, placenta, trachea and testis. Up-regulated in ovarian carcinoma, especially late-stage serous carcinoma, compared with normal ovaries and benign adenomas (at protein level). {ECO:0000269|PubMed:10974542, ECO:0000269|PubMed:12738725}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

KLK7 (C-15) - sc-20381 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

KLK7 (E-16) - sc-20380 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

KLK7 (H-5) - sc-514447 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

KLK7 (H-50) - sc-20625 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

KLK7 (1407) - sc-80148 from Santa Cruz Biotechnology Prices $279.00 Sizes 100 µg/ml Host Mouse Clonality Monoclonal

Anti-Kallikrein 7 antibody - ab200745 from Abcam Prices $359.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-Kallikrein 7 antibody - ab96710 from Abcam Prices $370.00 Sizes 50 µl Host Rabbit Clonality Polyclonal

Anti-Kallikrein 7 antibody - ab154707 from Abcam Prices $370.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-Kallikrein 7 antibody - ab172088 from Abcam Prices $370.00 Sizes 50 µg Host Mouse Clonality Polyclonal

Anti-Kallikrein 7 antibody - ab172103 from Abcam Prices $370.00 Sizes 50 µg Host Mouse Clonality Polyclonal

Anti-Kallikrein 7 antibody [MM0433-5J28] - ab89714 from Abcam Prices $370.00 Sizes 50 µg Host Mouse Clonality Monoclonal Clone MM0433-5J28

Anti-Kallikrein 7 antibody - Catalytic domain - ab40953 from Abcam Prices $370.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-Kallikrein 7 antibody - Kallikrein loop - ab28309 from Abcam Prices $370.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-KLK7 / Kallikrein 7 Antibody (aa75-104, APC) - LS-C215340 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-KLK7 / Kallikrein 7 Antibody (aa75-104, AP) - LS-C215341 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-KLK7 / Kallikrein 7 Antibody (aa75-104, Biotin) - LS-C215342 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-KLK7 / Kallikrein 7 Antibody (aa75-104, FITC) - LS-C215343 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-KLK7 / Kallikrein 7 Antibody (aa75-104, Azide-free, HRP) - LS-C215344 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-KLK7 / Kallikrein 7 Antibody (aa75-104, PE) - LS-C215345 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-KLK7 / Kallikrein 7 Antibody (aa23-253, Biotin) - LS-C298099 from LifeSpan Bioscience Prices $375.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-KLK7 / Kallikrein 7 Antibody (aa30-249, Biotin) - LS-C298100 from LifeSpan Bioscience Prices $425.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-KLK7 / Kallikrein 7 Antibody (aa24-255, Biotin) - LS-C300043 from LifeSpan Bioscience Prices $435.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-KLK7 / Kallikrein 7 Antibody (aa24-255, FITC) - LS-C302508 from LifeSpan Bioscience Prices $465.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-KLK7 / Kallikrein 7 Antibody (aa23-253, FITC) - LS-C302591 from LifeSpan Bioscience Prices $395.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-KLK7 / Kallikrein 7 Antibody (aa30-249, FITC) - LS-C302592 from LifeSpan Bioscience Prices $445.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

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