KLK7

Gene Symbol KLK7
Entrez Gene 5650
Alt Symbol PRSS6, SCCE, hK7
Species Human
Gene Type protein-coding
Description kallikrein-related peptidase 7
Other Description kallikrein 7 (chymotryptic, stratum corneum)|kallikrein-7|serine protease 6|signal protein|stratum corneum chymotryptic enzyme
Swissprots A8K0U5 Q8N5N9 Q8NFV7 P49862
Accessions AAD49718 AAG33360 AAK69624 CAA02644 CAG17626 EAW71958 EAW71959 EAW71960 EAW71961 P49862 AA101043 AF411214 AAN03662 AF411215 AAN03663 AI049783 AK289660 BAF82349 AK295313 BAG58291 AY601109 AAU04540 AY646152 AAT66047 BC032005 AAH32005 DA243628 DA307925 DQ018784 AAY97797 DQ890746 ABM81672 DQ893916 ABM84842 KF963189 AHN52223 KF963190 KF963191 KF963192 AHN52224 KF963193 L33404 AAC37551 NM_001243126 NP_001230055 NM_001207053 NP_001193982 NM_005046 NP_005037 NM_139277 NP_644806
Function May catalyze the degradation of intercellular cohesive structures in the cornified layer of the skin in the continuous shedding of cells from the skin surface. Specific for amino acid residues with aromatic side chains in the P1 position. Cleaves insulin A chain at '14-Tyr-|-Gln-15' and insulin B chain at '6- Leu-|-Cys-7', '16-Tyr-|-Leu-17', '25-Phe-|-Tyr-26' and '26-Tyr-|- Thr-27'. Could play a role in the activation of precursors to inflammatory cytokines. {ECO:0000269|PubMed:23370777}.
Subcellular Location Secreted {ECO:0000269|PubMed:12738725}. Note=In ovarian carcinoma, secreted and also observed at the apical membrane and in cytoplasm at the invasive front.
Tissue Specificity Abundantly expressed in the skin and is expressed by keratinocytes in the epidermis. Also expressed in the brain, mammary gland, cerebellum, spinal cord and kidney. Lower levels in salivary glands, uterus, thymus, thyroid, placenta, trachea and testis. Up-regulated in ovarian carcinoma, especially late-stage serous carcinoma, compared with normal ovaries and benign adenomas (at protein level). {ECO:0000269|PubMed:10974542, ECO:0000269|PubMed:12738725}.

Kallikrein-7 / KLK7 Lysate(Denatured) - H00005650-T01 from Acris Antibodies

Category Cell Lysate
Prices $320.00
Sizes 100 µl

Kallikrein-7 / KLK7 Lysate(Denatured) - H00005650-T02 from Acris Antibodies

Category Cell Lysate
Prices $320.00
Sizes 100 µl

KLK7 293 Cell Lysate - 408207 from ABBIOTEC

Category Cell Lysate
Prices $392.00
Sizes 100 µg

Kallikrein 7 Overexpression Lysate (Denatured) - H00005650-T02 from Novus Biologicals

Category Cell Lysate
Prices $299.00
Sizes 100 µl
Species Human
KLK7 transfected lysate.

Kallikrein 7 Overexpression Lysate (Denatured) - H00005650-T01 from Novus Biologicals

Category Cell Lysate
Prices $279.00
Sizes 100 µl

Kallikrein 7 Overexpression Lysate (Native) - NBP2-05573 from Novus Biologicals

Category Cell Lysate
Prices $329.00
Sizes 100 µg
Western Blot: Kallikrein 7 Overexpression Lysate (Adult Normal) [NBP2-05573] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for Kallikrein 7.

KLK7 (h): 293T Lysate - sc-113751 from Santa Cruz Biotechnology

Category Cell Lysate
Prices $205.00
Sizes 100 µg/200 µl
Species Human

KLK7 Over-expression Lysate Product - GWB-C325D6 from Genway Biotech

Category Cell Lysate
Prices $346.00
Sizes 100 µg
Species Human

Human KLK7 / PRSS6 HEK293 Cell Lysate (WB positive control) - 10416-H08HL-300 from Sino Biological

Category Cell Lysate
Prices $195.00
Sizes 300 µg
Species Human

Human KLK7 Human Cells Transfected Lysate (positive control) (denatured) - orb173398 from Biorbyt

Category Cell Lysate
Prices $604.00
Sizes 300 μg
Species Human

Panoply™ Human KLK7 Knockdown Stable Cell Line - CSC-DC008314 from Creative biogene

Category Cell Line
Species Human
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