| Gene Symbol | KLK7 |
|---|---|
| Entrez Gene | 5650 |
| Alt Symbol | PRSS6, SCCE, hK7 |
| Species | Human |
| Gene Type | protein-coding |
| Description | kallikrein-related peptidase 7 |
| Other Description | kallikrein 7 (chymotryptic, stratum corneum)|kallikrein-7|serine protease 6|signal protein|stratum corneum chymotryptic enzyme |
| Swissprots | A8K0U5 Q8N5N9 Q8NFV7 P49862 |
| Accessions | AAD49718 AAG33360 AAK69624 CAA02644 CAG17626 EAW71958 EAW71959 EAW71960 EAW71961 P49862 AA101043 AF411214 AAN03662 AF411215 AAN03663 AI049783 AK289660 BAF82349 AK295313 BAG58291 AY601109 AAU04540 AY646152 AAT66047 BC032005 AAH32005 DA243628 DA307925 DQ018784 AAY97797 DQ890746 ABM81672 DQ893916 ABM84842 KF963189 AHN52223 KF963190 KF963191 KF963192 AHN52224 KF963193 L33404 AAC37551 NM_001243126 NP_001230055 NM_001207053 NP_001193982 NM_005046 NP_005037 NM_139277 NP_644806 |
| Function | May catalyze the degradation of intercellular cohesive structures in the cornified layer of the skin in the continuous shedding of cells from the skin surface. Specific for amino acid residues with aromatic side chains in the P1 position. Cleaves insulin A chain at '14-Tyr-|-Gln-15' and insulin B chain at '6- Leu-|-Cys-7', '16-Tyr-|-Leu-17', '25-Phe-|-Tyr-26' and '26-Tyr-|- Thr-27'. Could play a role in the activation of precursors to inflammatory cytokines. {ECO:0000269|PubMed:23370777}. |
| Subcellular Location | Secreted {ECO:0000269|PubMed:12738725}. Note=In ovarian carcinoma, secreted and also observed at the apical membrane and in cytoplasm at the invasive front. |
| Tissue Specificity | Abundantly expressed in the skin and is expressed by keratinocytes in the epidermis. Also expressed in the brain, mammary gland, cerebellum, spinal cord and kidney. Lower levels in salivary glands, uterus, thymus, thyroid, placenta, trachea and testis. Up-regulated in ovarian carcinoma, especially late-stage serous carcinoma, compared with normal ovaries and benign adenomas (at protein level). {ECO:0000269|PubMed:10974542, ECO:0000269|PubMed:12738725}. |
KLK7 CRISPR/Cas9 KO Plasmid (h) - sc-403539 from Santa Cruz Biotechnology
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KLK7 HDR Plasmid (h) - sc-403539-HDR from Santa Cruz Biotechnology
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KLK7 Double Nickase Plasmid (h) - sc-403539-NIC from Santa Cruz Biotechnology
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KLK7 Double Nickase Plasmid (h2) - sc-403539-NIC-2 from Santa Cruz Biotechnology
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KLK7 CRISPR Activation Plasmid (h) - sc-403539-ACT from Santa Cruz Biotechnology
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KLK7 CRISPR Activation Plasmid (h2) - sc-403539-ACT-2 from Santa Cruz Biotechnology
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KLK7 Lentiviral Activation Particles (h) - sc-403539-LAC from Santa Cruz Biotechnology
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KLK7 Lentiviral Activation Particles (h2) - sc-403539-LAC-2 from Santa Cruz Biotechnology
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KLK7 siRNA (h) - sc-41533 from Santa Cruz Biotechnology
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KLK7 shRNA Plasmid (h) - sc-41533-SH from Santa Cruz Biotechnology
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KLK7 shRNA (h) Lentiviral Particles - sc-41533-V from Santa Cruz Biotechnology
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Kallikrein 7 RNAi - H00005650-R01 from Novus Biologicals
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Kallikrein 7 RNAi - H00005650-R02 from Novus Biologicals
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MISSION® esiRNA - EHU088991 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN11314 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND11314 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR08056 from Sigma-Aldrich
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KLK7 siRNA (Human) - CRH3808 from Cohesion Biosciences
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KLK7 CRISPR/Cas9 KO Plasmid (h2) - sc-403539-KO-2 from Santa Cruz Biotechnology
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KLK7 HDR Plasmid (h2) - sc-403539-HDR-2 from Santa Cruz Biotechnology
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shRNA set against Human KLK7 (NM_005046.3) - SHH326623 from Creative biogene
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KLK7 shRNA Plasmid (Human) - CHH3808 from Cohesion Biosciences
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KLK7 miRNA 3'UTR clone - MiUTR3H-06801 from Creative biogene
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KLK7 miRNA 3'UTR clone - MiUTR3H-06802 from Creative biogene
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