KLK7

Gene Symbol	KLK7
Entrez Gene	5650
Alt Symbol	PRSS6, SCCE, hK7
Species	Human
Gene Type	protein-coding
Description	kallikrein-related peptidase 7
Other Description	kallikrein 7 (chymotryptic, stratum corneum)|kallikrein-7|serine protease 6|signal protein|stratum corneum chymotryptic enzyme
Swissprots	A8K0U5 Q8N5N9 Q8NFV7 P49862
Accessions	AAD49718 AAG33360 AAK69624 CAA02644 CAG17626 EAW71958 EAW71959 EAW71960 EAW71961 P49862 AA101043 AF411214 AAN03662 AF411215 AAN03663 AI049783 AK289660 BAF82349 AK295313 BAG58291 AY601109 AAU04540 AY646152 AAT66047 BC032005 AAH32005 DA243628 DA307925 DQ018784 AAY97797 DQ890746 ABM81672 DQ893916 ABM84842 KF963189 AHN52223 KF963190 KF963191 KF963192 AHN52224 KF963193 L33404 AAC37551 NM_001243126 NP_001230055 NM_001207053 NP_001193982 NM_005046 NP_005037 NM_139277 NP_644806
Function	May catalyze the degradation of intercellular cohesive structures in the cornified layer of the skin in the continuous shedding of cells from the skin surface. Specific for amino acid residues with aromatic side chains in the P1 position. Cleaves insulin A chain at '14-Tyr-|-Gln-15' and insulin B chain at '6- Leu-|-Cys-7', '16-Tyr-|-Leu-17', '25-Phe-|-Tyr-26' and '26-Tyr-|- Thr-27'. Could play a role in the activation of precursors to inflammatory cytokines. {ECO:0000269|PubMed:23370777}.
Subcellular Location	Secreted {ECO:0000269|PubMed:12738725}. Note=In ovarian carcinoma, secreted and also observed at the apical membrane and in cytoplasm at the invasive front.
Tissue Specificity	Abundantly expressed in the skin and is expressed by keratinocytes in the epidermis. Also expressed in the brain, mammary gland, cerebellum, spinal cord and kidney. Lower levels in salivary glands, uterus, thymus, thyroid, placenta, trachea and testis. Up-regulated in ovarian carcinoma, especially late-stage serous carcinoma, compared with normal ovaries and benign adenomas (at protein level). {ECO:0000269|PubMed:10974542, ECO:0000269|PubMed:12738725}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human-KLK7-cDNA-Clone - DC06318 from Abgent, a WuXi AppTec company Prices $341.55 Sizes 10 µg Species Human Accession BC032005

KLK7 - MBS1267370 from MyBioSource Prices $175.00 Sizes 10ug plasmid + 200ul glycerol stock Species Human Accession BC032005

Human KLK7 ORF Clone(NM_005046.3) - CDCL168239 from Creative Biomart Species Human Accession NM_005046.3

Human KLK7/Kallikrein 7(PRSS6) transcript variant 1 Gene ORF cDNA clone in cloning vector - HG10416-M from Sino Biological Species Human

Human KLK7/Kallikrein 7(PRSS6) transcript variant 1 Gene ORF cDNA clone expression plasmid, C-Flag tag - HG10416-M-F from Sino Biological Species Human

Human KLK7/Kallikrein 7(PRSS6) transcript variant 1 Gene ORF cDNA clone expression plasmid, C-OFPSpark tag - HG10416-ACR from Sino Biological Species Human

Human KLK7/Kallikrein 7(PRSS6) transcript variant 1 Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - HG10416-ACG from Sino Biological Species Human

Human KLK7/Kallikrein 7(PRSS6) transcript variant 1 Gene ORF cDNA clone expression plasmid, N-His tag - HG10416-NH from Sino Biological Species Human

Human KLK7/Kallikrein 7(PRSS6) transcript variant 1 Gene ORF cDNA clone expression plasmid - HG10416-UT from Sino Biological Species Human

Human KLK7/Kallikrein 7(PRSS6) transcript variant 1 Gene ORF cDNA clone expression plasmid, N-Flag tag - HG10416-NF from Sino Biological Species Human

Human KLK7/Kallikrein 7(PRSS6) transcript variant 1 Gene ORF cDNA clone expression plasmid, N-Myc tag - HG10416-NM from Sino Biological Species Human

Human KLK7/Kallikrein 7(PRSS6) transcript variant 1 Gene ORF cDNA clone expression plasmid, C-HA tag - HG10416-CY from Sino Biological Species Human

Human KLK7/Kallikrein 7(PRSS6) transcript variant 1 Gene ORF cDNA clone expression plasmid, C-Flag tag - HG10416-CF from Sino Biological Species Human

Human KLK7/Kallikrein 7(PRSS6) transcript variant 1 Gene ORF cDNA clone expression plasmid, N-HA tag - HG10416-NY from Sino Biological Species Human

Human KLK7/Kallikrein 7(PRSS6) transcript variant 1 Gene ORF cDNA clone expression plasmid, C-His tag - HG10416-CH from Sino Biological Species Human

Human KLK7/Kallikrein 7(PRSS6) transcript variant 1 Gene ORF cDNA clone expression plasmid, C-Myc tag - HG10416-CM from Sino Biological Species Human

Human KLK7 ORF Clone (BC032005) - CDCS409835 from Creative biogene Species Human Accession P49862

Human KLK7 ORF clone (NM_005046.2) - CDCB157457 from Creative biogene Species Human

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