KLK7

Gene Symbol	KLK7
Entrez Gene	5650
Alt Symbol	PRSS6, SCCE, hK7
Species	Human
Gene Type	protein-coding
Description	kallikrein-related peptidase 7
Other Description	kallikrein 7 (chymotryptic, stratum corneum)|kallikrein-7|serine protease 6|signal protein|stratum corneum chymotryptic enzyme
Swissprots	A8K0U5 Q8N5N9 Q8NFV7 P49862
Accessions	AAD49718 AAG33360 AAK69624 CAA02644 CAG17626 EAW71958 EAW71959 EAW71960 EAW71961 P49862 AA101043 AF411214 AAN03662 AF411215 AAN03663 AI049783 AK289660 BAF82349 AK295313 BAG58291 AY601109 AAU04540 AY646152 AAT66047 BC032005 AAH32005 DA243628 DA307925 DQ018784 AAY97797 DQ890746 ABM81672 DQ893916 ABM84842 KF963189 AHN52223 KF963190 KF963191 KF963192 AHN52224 KF963193 L33404 AAC37551 NM_001243126 NP_001230055 NM_001207053 NP_001193982 NM_005046 NP_005037 NM_139277 NP_644806
Function	May catalyze the degradation of intercellular cohesive structures in the cornified layer of the skin in the continuous shedding of cells from the skin surface. Specific for amino acid residues with aromatic side chains in the P1 position. Cleaves insulin A chain at '14-Tyr-|-Gln-15' and insulin B chain at '6- Leu-|-Cys-7', '16-Tyr-|-Leu-17', '25-Phe-|-Tyr-26' and '26-Tyr-|- Thr-27'. Could play a role in the activation of precursors to inflammatory cytokines. {ECO:0000269|PubMed:23370777}.
Subcellular Location	Secreted {ECO:0000269|PubMed:12738725}. Note=In ovarian carcinoma, secreted and also observed at the apical membrane and in cytoplasm at the invasive front.
Tissue Specificity	Abundantly expressed in the skin and is expressed by keratinocytes in the epidermis. Also expressed in the brain, mammary gland, cerebellum, spinal cord and kidney. Lower levels in salivary glands, uterus, thymus, thyroid, placenta, trachea and testis. Up-regulated in ovarian carcinoma, especially late-stage serous carcinoma, compared with normal ovaries and benign adenomas (at protein level). {ECO:0000269|PubMed:10974542, ECO:0000269|PubMed:12738725}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human Kallikrein 7 full length protein - ab191666 from Abcam Category Protein Prices $721.00 Sizes 50 µg Source HEK 293 cells Species Human

Human Kallikrein 7 full length protein - ab134589 from Abcam Category Protein Source E. coli Species Human

Human Kallikrein 7 full length protein - ab151642 from Abcam Category Protein Source HEK 293 cells Species Human

Human Kallikrein 7 protein fragment - ab114437 from Abcam Category Protein Source Wheat germ Species Human

Kallikrein 7 peptide - ab41385 from Abcam Category Peptide

Kallikrein 7 peptide - ab43089 from Abcam Category Peptide

KLK7 / Kallikrein 7 Antibody Blocking Peptide - LS-E21089 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human Kallikrein 7 Protein - H00005650-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Source Wheat Germ Species Human

Kallikrein 7 Partial Recombinant Protein - H00005650-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human Kallikrein 7 Protein - NBP2-23163 from Novus Biologicals Category Protein Prices $269.00 Sizes 100 µg Source E.coli Species Human

Kallikrein-7-Antibody-C-term-Blocking-peptide - BP6326b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Recombinant Human Kallikrein 7, CF - 2624-SE-010 from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived, Glu23-His252, with a C-terminal 10-His tag

Recombinant human Kallikrein-7 protein (OPCA00146) - OPCA00146 from Aviva Systems Biology Category Protein Prices $220.00 Sizes 50 µg Species Human

Recombinant human Kallikrein-7 protein (OPCA01265) - OPCA01265 from Aviva Systems Biology Category Protein Prices $220.00 Sizes 50 µg Species Human

KLK7 Protein (OPPA02324) - OPPA02324 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 5 µg Source HEK293-F Cells

Human Kallikrein 7 protein - orb49494 from Biorbyt Category Protein Prices $408.00, $595.00, $1,904.00, $2,695.00 Sizes 10 μg, 50 μg, 500 μg, 1 mg Species Human

Human KLK7 protein - orb245897 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

Human KLK7 protein - orb90159 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 5 μg, 20 μg Source HEK293-F Cells Species Human

KLK7 protein (His tag) - 80R-2489 from Fitzgerald Category Protein Prices $270.00 Sizes 100 µg Source E.coli

Human Kallikrein 7 Protein - abx067593 from Abbexa Category Protein Source E.coli Species Human

KLK7 / Kallikrein-7 (30-253, His-tag) - AR50561PU-N from Acris Antibodies Category Protein Prices $790.00 Sizes 500 µg Source E. coli Species Human

KLK7 / Kallikrein-7 (30-253, His-tag) - AR50561PU-S from Acris Antibodies Category Protein Prices $340.00 Sizes 100 µg Source E. coli Species Human

KLK7 / Kallikrein-7 - H00005650-P01 from Acris Antibodies Category Protein Prices $340.00 Sizes 2 µg Species Human

KLK7 / Kallikrein-7 - H00005650-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

KLK7 / Kallikrein-7 - H00005650-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

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