DKK4

Gene Symbol	DKK4
Entrez Gene	27121
Alt Symbol	DKK-4
Species	Human
Gene Type	protein-coding
Description	dickkopf WNT signaling pathway inhibitor 4
Other Description	dickkopf-4|dickkopf-related protein 4|hDkk-4
Swissprots	Q3KNX0 Q9UBT3 Q9Y4C3
Accessions	BAA33475 CAR82119 EAW63220 Q9UBT3 AB017788 BAA33438 AF177397 AAF02677 AK301609 BAG63095 BC107046 AAI07047 BC107047 AAI07048 BX105775 XM_011544486 XP_011542788 XM_011544487 XP_011542789 XM_011544488 XP_011542790 XM_011544489 XP_011542791 NM_014420 NP_055235
Function	Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero- posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity). {ECO:0000250}.
Subcellular Location	Secreted.
Tissue Specificity	Expressed in cerebellum, T-cells, esophagus and lung.
Top Pathways	Wnt signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Dkk-4 (H-14) - sc-14962 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Dkk-4 (H-80) - sc-25519 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

Dkk-4 (T-20) - sc-14961 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Anti-DKK4 antibody - ab38589 from Abcam Prices $370.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-DKK4 antibody - ab2342 from Abcam Prices $370.00 Sizes 100 µg Host Goat Clonality Polyclonal

Anti-DKK4 antibody - ab130822 from Abcam Prices $359.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-DKK4 antibody - ab172439 from Abcam Prices $370.00 Sizes 50 µg Host Mouse Clonality Polyclonal

Anti-DKK4 antibody [EPR7867(2)] - ab172613 from Abcam Prices $357.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EPR7867(2)

Anti-DKK4 antibody [MM0472-9M19] - ab135204 from Abcam Prices $370.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone MM0472-9M19

Anti-DKK4 antibody - N-terminal - ab150516 from Abcam Prices $407.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-DKK4 Antibody (C-Terminus, FITC) - LS-C244169 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-DKK4 Antibody (N-Terminus, Azide-free, HRP) - LS-C247536 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-DKK4 Antibody (C-Terminus, PE) - LS-C244173 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-DKK4 Antibody (C-Terminus, Azide-free, HRP) - LS-C247538 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-DKK4 Antibody (aa162-189, Azide-free, HRP) - LS-C249837 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-DKK4 Antibody (aa37-141, FITC) - LS-C305006 from LifeSpan Bioscience Prices $495.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-DKK4 Antibody (aa37-141, Biotin) - LS-C300601 from LifeSpan Bioscience Prices $465.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-DKK4 Antibody - LS-C310140 from LifeSpan Bioscience Prices $475.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-DKK4 Antibody (aa169-197) - LS-C320851 from LifeSpan Bioscience Prices $345.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-DKK4 Antibody (C-Terminus) - LS-C327199 from LifeSpan Bioscience Prices $345.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-DKK4 Antibody (N-Terminus) - LS-C327200 from LifeSpan Bioscience Prices $345.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-DKK4 Antibody (aa37-141) - LS-C293684 from LifeSpan Bioscience Prices $435.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-DKK4 Antibody - LS-C125462 from LifeSpan Bioscience Prices $425.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-DKK4 Antibody (aa162-189, AP) - LS-C234612 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-DKK4 Antibody (aa147-196) - LS-C151229 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

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