DKK4

Gene Symbol	DKK4
Entrez Gene	27121
Alt Symbol	DKK-4
Species	Human
Gene Type	protein-coding
Description	dickkopf WNT signaling pathway inhibitor 4
Other Description	dickkopf-4|dickkopf-related protein 4|hDkk-4
Swissprots	Q3KNX0 Q9UBT3 Q9Y4C3
Accessions	BAA33475 CAR82119 EAW63220 Q9UBT3 AB017788 BAA33438 AF177397 AAF02677 AK301609 BAG63095 BC107046 AAI07047 BC107047 AAI07048 BX105775 XM_011544486 XP_011542788 XM_011544487 XP_011542789 XM_011544488 XP_011542790 XM_011544489 XP_011542791 NM_014420 NP_055235
Function	Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero- posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity). {ECO:0000250}.
Subcellular Location	Secreted.
Tissue Specificity	Expressed in cerebellum, T-cells, esophagus and lung.
Top Pathways	Wnt signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human DKK4 full length protein - ab131845 from Abcam Category Protein Source Wheat germ Species Human

Human DKK4 peptide - ab22902 from Abcam Category Peptide Species Human

DKK4 Antibody Blocking Peptide - LS-E1126 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

DKK4 Antibody Blocking Peptide - LS-E3798 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

DKK4 Antibody Blocking Peptide - LS-E3797 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

DKK4 Antibody Blocking Peptide - LS-E25319 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

DKK4 Antibody Blocking Peptide - LS-E15610 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Dkk-4 Recombinant Protein - H00027121-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Species Human

Dkk-4 Peptide - P0534 from Novus Biologicals Category Peptide Species Human

Dkk-4 Peptide - P0533 from Novus Biologicals Category Peptide Species Human

DKK4-Antibody-C-term-Blocking-peptide - BP11649b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

DKK4-Antibody-C-term-Blocking-Peptide - BP1524b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

DKK4-Antibody-N-term-Blocking-Peptide - BP1524a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

DKK4 blocking peptide - GTX89941-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human

Recombinant Human Dkk-4 - 1269-DK-010 from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived, Leu19-Leu224, with a C-terminal 10-His tag

Recombinant Human Dkk-4, CF - 1269-DK-010/CF from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived, Leu19-Leu224, with a C-terminal 10-His tag

DKK4 Blocking Peptide - 33R-10983 from Fitzgerald Category Peptide Prices $145.00 Sizes 50 µg

DKK4 Blocking Peptide - 33R-10566 from Fitzgerald Category Peptide Prices $295.00 Sizes 50 µg

DKK4 Peptide - AC21-0147-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

Dickkopf-4 (DKK4) - H00027121-P01 from Acris Antibodies Category Protein Prices $340.00 Sizes 2 µg Species Human

Dickkopf-4 (DKK4) - H00027121-P01-10 from Acris Antibodies Category Protein Prices $370.00 Sizes 10 µg Species Human

Dickkopf-4 (DKK4) - H00027121-P01-25 from Acris Antibodies Category Protein Prices $520.00 Sizes 25 µg Species Human

Recombinant Human DKK4 - 230-00548-10 from RayBiotech Category Protein Prices $110.00 Sizes 10 µg Source Escherichia coli (E.coli) Species Human

Recombinant Human DKK4 - 230-00548-50 from RayBiotech Category Protein Prices $224.00 Sizes 50 µg Source Escherichia coli (E.coli) Species Human

Recombinant Human DKK4 - 230-00548-100 from RayBiotech Category Protein Prices $336.00 Sizes 100 µg Source Escherichia coli (E.coli) Species Human

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