DKK4

Gene Symbol DKK4
Entrez Gene 27121
Alt Symbol DKK-4
Species Human
Gene Type protein-coding
Description dickkopf WNT signaling pathway inhibitor 4
Other Description dickkopf-4|dickkopf-related protein 4|hDkk-4
Swissprots Q3KNX0 Q9UBT3 Q9Y4C3
Accessions BAA33475 CAR82119 EAW63220 Q9UBT3 AB017788 BAA33438 AF177397 AAF02677 AK301609 BAG63095 BC107046 AAI07047 BC107047 AAI07048 BX105775 XM_011544486 XP_011542788 XM_011544487 XP_011542789 XM_011544488 XP_011542790 XM_011544489 XP_011542791 NM_014420 NP_055235
Function Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero- posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity). {ECO:0000250}.
Subcellular Location Secreted.
Tissue Specificity Expressed in cerebellum, T-cells, esophagus and lung.
Top Pathways Wnt signaling pathway

Dkk-4 CRISPR/Cas9 KO Plasmid (h) - sc-406386 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Dkk-4 HDR Plasmid (h) - sc-406386-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Dkk-4 Double Nickase Plasmid (h) - sc-406386-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Dkk-4 Double Nickase Plasmid (h2) - sc-406386-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Dkk-4 CRISPR Activation Plasmid (h) - sc-406386-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Dkk-4 CRISPR Activation Plasmid (h2) - sc-406386-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Dkk-4 Lentiviral Activation Particles (h) - sc-406386-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Dkk-4 Lentiviral Activation Particles (h2) - sc-406386-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Dkk-4 siRNA (h) - sc-41104 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Dkk-4 shRNA Plasmid (h) - sc-41104-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Dkk-4 shRNA (h) Lentiviral Particles - sc-41104-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

CompoZr® Knockout ZFN Kit - CKOZFN7277 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND7277 from Sigma-Aldrich

Category ZFN Kit
Prices $4,120.00
Sizes 1 kt

DKK4 siRNA (Human) - CRH8975 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

DKK4 - MBS8220242 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human DKK4 (NM_014420.2) - SHH278377 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human DKK4(NM_014420.2) - SHH006239 from Creative biogene

Category siRNA
Species Reactivities Human

Human DKK4 siRNA - orb269477 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

DKK4 shRNA Plasmid (Human) - CHH8975 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

DKK4 miRNA 3'UTR clone - MiUTR1H-02860 from Creative biogene

Species Reactivities Human
Search more