| Gene Symbol |
DKK4
|
| Entrez Gene |
27121
|
| Alt Symbol |
DKK-4
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
dickkopf WNT signaling pathway inhibitor 4
|
| Other Description |
dickkopf-4|dickkopf-related protein 4|hDkk-4
|
| Swissprots |
Q3KNX0 Q9UBT3 Q9Y4C3
|
| Accessions |
BAA33475 CAR82119 EAW63220 Q9UBT3 AB017788 BAA33438 AF177397 AAF02677 AK301609 BAG63095 BC107046 AAI07047 BC107047 AAI07048 BX105775 XM_011544486 XP_011542788 XM_011544487 XP_011542789 XM_011544488 XP_011542790 XM_011544489 XP_011542791 NM_014420 NP_055235
|
| Function |
Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero- posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Secreted.
|
| Tissue Specificity |
Expressed in cerebellum, T-cells, esophagus and lung.
|
| Top Pathways |
Wnt signaling pathway
|
