DKK4

Gene Symbol	DKK4
Entrez Gene	27121
Alt Symbol	DKK-4
Species	Human
Gene Type	protein-coding
Description	dickkopf WNT signaling pathway inhibitor 4
Other Description	dickkopf-4|dickkopf-related protein 4|hDkk-4
Swissprots	Q3KNX0 Q9UBT3 Q9Y4C3
Accessions	BAA33475 CAR82119 EAW63220 Q9UBT3 AB017788 BAA33438 AF177397 AAF02677 AK301609 BAG63095 BC107046 AAI07047 BC107047 AAI07048 BX105775 XM_011544486 XP_011542788 XM_011544487 XP_011542789 XM_011544488 XP_011542790 XM_011544489 XP_011542791 NM_014420 NP_055235
Function	Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero- posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity). {ECO:0000250}.
Subcellular Location	Secreted.
Tissue Specificity	Expressed in cerebellum, T-cells, esophagus and lung.
Top Pathways	Wnt signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

DKK4 (Dickkopf-4) Human ELISA Kit - ab100503 from Abcam Category ELISA Kit Prices $489.00 Sizes 1 x 96 tests Sensitivity < 10 pg/ml Range 13.72 pg/ml - 10000 pg/ml

Human DKK4 ELISA Kit (Sandwich ELISA) - LS-F66 from LifeSpan Bioscience Category ELISA Kit Prices $460.00, $840.00, $1,960.00 Sizes 1 plate, 2 plate, 5 plate Sensitivity 13.71 pg/ml Range 13.71-3333 pg/ml

Human DKK4 ELISA Kit (Sandwich ELISA) - LS-F7295 from LifeSpan Bioscience Category ELISA Kit Prices $790.00 Sizes 1 plate Sensitivity 0.067 ng/ml Range 13.71-3333 pg/ml

Mouse DKK4 ELISA Kit (Sandwich ELISA) - LS-F7296 from LifeSpan Bioscience Category ELISA Kit Prices $810.00 Sizes 1 plate Sensitivity 0.051 ng/ml Range 13.71-3333 pg/ml

Human DKK4 ELISA Kit (Sandwich ELISA) - LS-F11304 from LifeSpan Bioscience Category ELISA Kit Prices $530.00 Sizes 1 plate Sensitivity 0.156 Range 13.71-3333 pg/ml

Human Dkk-4 ELISA Kit - RAB0146 from Sigma-Aldrich Category ELISA Kit Prices $423.50 Sizes 1 kt

Human Dkk-4 DuoSet ELISA - DY1269 from R&D Systems Category ELISA Kit Prices $649.00 Sizes 1 kit (for 15 Plates) Range 125.00 - 8,000 pg/mL

Human DKK4 ELISA Kit - abx151324 from Abbexa Category ELISA Kit Sensitivity 0.067 ng/ml Range 0.156 ng/ml - 10 ng/ml

Dickkopf Related Protein 4 (DKK4), Human, ELISA Kit - SEQ088Hu from ARP American Research Products Category ELISA Kit Prices $790.00 Sizes 96 t Sensitivity 0.067ng/mL Range 0.156-10ng/mL

Dickkopf-related protein 4 (DKK4), Human, ELISA Kit - CSB-EL006923HU from ARP American Research Products Category ELISA Kit Prices $495.00, $695.00, $696.00, $699.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t

Dickkopf-related protein 4, DKK4, Human, ELISA Kit - E5890h from ARP American Research Products Category ELISA Kit Prices $576.00 Sizes 96 t Range 0.156-10 ng/mL

Dickkopf Related Protein 4, DKK4, Human, ELISA Kit - E-EL-H0842 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t Sensitivity 0.094 Range 0.156-10ng/mL

Dickkopf Related Protein 4, DKK4, Rabbit, ELISA Kit - E-EL-RB0715 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Dickkopf Related Protein 4, DKK4, Chicken, ELISA Kit - E-EL-Ch0857 from ARP American Research Products Category ELISA Kit Prices $504.00 Sizes 96 t

Dickkopf Related Protein 4, DKK4, Porcine, ELISA Kit - E-EL-P0296 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Dickkopf Related Protein 4, DKK4, Guinea Pig, ELISA Kit - E-EL-GP0305 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t

Dickkopf Related Protein 4, DKK4, Monkey, ELISA Kit - E-EL-MK1272 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

DKK4 (Human) ELISA Kit - KA1707 from Acris Antibodies Category ELISA Kit Prices $650.00 Sizes 1 kit

Human Dkk-4 ELISA - ELH-DKK4 from RayBiotech Category ELISA Kit Prices $390.00, $702.00, $1,561.00 Sizes 1 plate kit, 2 plate kit, 5 plate kit Sensitivity 10 pg/ml Range 10 pg/ml - 10000 pg/ml

Dickkopf Related Protein 4 (DKK4), ELISA Kit - MBS2022216 from MyBioSource Category ELISA Kit Prices $420.00, $625.00, $855.00, $3,510.00, $6,365.00 Sizes 24 -strip-wells, 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity Typically less than 0.051ng/mL. Range 0.156-10ng/mL

Dickkopf Related Protein 4 (DKK4), ELISA Kit - MBS9309074 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Dickkopf Related Protein 4 (DKK4), ELISA Kit - MBS2021270 from MyBioSource Category ELISA Kit Prices $410.00, $610.00, $830.00, $3,420.00, $6,200.00 Sizes 24 -strip-wells, 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity Typically less than 0.067ng/mL. Range 0.156-10ng/mL

DKK4 (Human) ELISA Kit - DEIA3334 from Creative Diagnostics Category ELISA Kit Sensitivity The minimum detectable dose of Dkk-4 is typically less than 10 pg/mL

Human DKK4(Dickkopf Related Protein 4) ELISA Kit - E-EL-H0842 from Elabscience Category ELISA Kit Sensitivity 0.10 ng/mL Range 0.16—10 ng/mL

Human DKK4 (Dickkopf Related Protein 4) CLIA Kit - E-CL-H0588 from Elabscience Category CLIA Kit Sensitivity 18.75 pg/mL Range Average Recovery (%)

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