ULBP1

Gene Symbol ULBP1
Entrez Gene 80329
Alt Symbol RAET1I
Species Human
Gene Type protein-coding
Description UL16 binding protein 1
Other Description N2DL-1|NKG2D ligand 1|NKG2DL1|UL16-binding protein 1|alcan-beta|retinoic acid early transcript 1I
Swissprots Q8IZX6 Q9BZM6 Q8IZW3 Q5VY81
Accessions EAW47776 Q9BZM6 AB052907 BAB61049 AF304377 AAK13081 AF346416 AAL76416 AF346595 AAN40838 AF425265 AAN32759 AK292519 BAF85208 AK316582 BAG38170 BC035416 AAH35416 NM_025218 NP_079494
Function Ligand for the KLRK1/NKG2D receptor, together with at least ULBP2 and ULBP3. ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to KLRK1/NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction pathway. In CMV infected cells, interacts with soluble CMV glycoprotein UL16. The interaction with UL16 blocked the interaction with the KLRK1/NKG2D receptor, providing a mechanism by which CMV infected cells might escape the immune system. UL16 also causes ULBP1 to be retained in the ER and cis-Golgi apparatus so that it does not reach the cell surface. {ECO:0000269|PubMed:11777960}.
Subcellular Location Cell membrane {ECO:0000269|PubMed:12782710}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:12782710}. Endoplasmic reticulum {ECO:0000269|PubMed:12782710}. Note=Detected intracellularly in the endoplasmic reticulum of CMV-infected fibroblasts.
Tissue Specificity Expressed in T-cells, B-cells, erythroleukemia cell lines and in a wide range of tissues including heart, brain, lung, liver, testis, lymph node, thymus, tonsil and bone marrow. Also found in fetal heart, brain, lung and liver.
Top Pathways Natural killer cell mediated cytotoxicity

Human ULBP-1 DuoSet ELISA - DY1380 from R&D Systems

Category ELISA Kit
Prices $649.00
Sizes 1 kit (for 15 Plates)
Range 93.80 - 6,000 pg/mL

Custom Human ULBP-1 ELISA - ELH-ULBP1 from RayBiotech

Category ELISA Kit
Prices $615.00, $1,107.00, $2,460.00
Sizes 1 plate kit, 2 plate kit, 5 plate kit

UL16 Binding protein 1, ELISA Kit - MBS750093 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

UL16 Binding protein 1, ELISA Kit - MBS750872 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

UL16 Binding protein 1, ELISA Kit - MBS744273 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity 0.1 ng/mL.

UL16 Binding protein 1, ELISA Kit - MBS755284 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity 0.1 ng/mL.

UL16 Binding protein 1, ELISA Kit - MBS751225 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

UL16 Binding protein 1, ELISA Kit - MBS745616 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

UL16 Binding protein 1, ELISA Kit - MBS748448 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

UL16 Binding protein 1, ELISA Kit - MBS745392 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity 0.1 ng/mL.

UL16 Binding protein 1, ELISA Kit - MBS750012 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

UL16 Binding protein 1, ELISA Kit - MBS748239 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

UL16 Binding protein 1, ELISA Kit - MBS752604 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

UL16 binding protein 1, ELISA Kit - MBS9339877 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity 10 pg/ml.
Range 62.5 pg/ml - 2000 pg/ml.

UL16 Binding protein 1, ELISA Kit - MBS749289 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Human ULBP-1 ELISA kit - orb196745 from Biorbyt

Category ELISA Kit
Prices $765.00, $1,292.00, $2,754.00
Sizes 96 assays, 192 assays, 480 assays

Human ULBP-1 ELISA Kit - RAB1094 from Sigma-Aldrich

Category ELISA Kit
Prices $390.00
Sizes 1 kt
Sensitivity 0.4 ng/ml

Human ULBP-1 ELISA Kit - NR-E10436 from Novatein Biosciences

Category ELISA Kit
Prices $532.50, $1,049.50, $1,878.90
Sizes 1x96t, 2x96t, 4x96t
Range 93.75 -6000pg/ml

Human ULBP-1 ELISA - ELH-ULBP1-1 from RayBiotech

Category ELISA Kit
Prices $390.00, $702.00, $1,560.00
Sizes 1 plate kit, 2 plate kit, 5 plate kit

Human ULBP1 ELISA Kit - E090714 from Biobool

Category ELISA Kit

NKG2D Ligand 1 (ULBP1), ELISA Kit - MBS9345581 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

NKG2D Ligand 1 (ULBP1), ELISA Kit - MBS9346883 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

NKG2D Ligand 1 (ULBP1), ELISA Kit - MBS9367479 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

NKG2D Ligand 1 (ULBP1), ELISA Kit - MBS9354524 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

NKG2D Ligand 1 (ULBP1), ELISA Kit - MBS9354860 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
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