ULBP1

Gene Symbol	ULBP1
Entrez Gene	80329
Alt Symbol	RAET1I
Species	Human
Gene Type	protein-coding
Description	UL16 binding protein 1
Other Description	N2DL-1|NKG2D ligand 1|NKG2DL1|UL16-binding protein 1|alcan-beta|retinoic acid early transcript 1I
Swissprots	Q8IZX6 Q9BZM6 Q8IZW3 Q5VY81
Accessions	EAW47776 Q9BZM6 AB052907 BAB61049 AF304377 AAK13081 AF346416 AAL76416 AF346595 AAN40838 AF425265 AAN32759 AK292519 BAF85208 AK316582 BAG38170 BC035416 AAH35416 NM_025218 NP_079494
Function	Ligand for the KLRK1/NKG2D receptor, together with at least ULBP2 and ULBP3. ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to KLRK1/NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction pathway. In CMV infected cells, interacts with soluble CMV glycoprotein UL16. The interaction with UL16 blocked the interaction with the KLRK1/NKG2D receptor, providing a mechanism by which CMV infected cells might escape the immune system. UL16 also causes ULBP1 to be retained in the ER and cis-Golgi apparatus so that it does not reach the cell surface. {ECO:0000269|PubMed:11777960}.
Subcellular Location	Cell membrane {ECO:0000269|PubMed:12782710}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:12782710}. Endoplasmic reticulum {ECO:0000269|PubMed:12782710}. Note=Detected intracellularly in the endoplasmic reticulum of CMV-infected fibroblasts.
Tissue Specificity	Expressed in T-cells, B-cells, erythroleukemia cell lines and in a wide range of tissues including heart, brain, lung, liver, testis, lymph node, thymus, tonsil and bone marrow. Also found in fetal heart, brain, lung and liver.
Top Pathways	Natural killer cell mediated cytotoxicity

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human ALCAN-beta Gene - orb91452 from Biorbyt Prices $255.00 Sizes 10 μg Species Human

Human ULBP-1 (NP_079494) VersaClone cDNA - RDC0804 from R&D Systems Prices $199.00 Sizes 10 µg Species Human

Human ULBP1 cDNA clone(NM_025218.2) - CDFG005003 from Creative Biomart Species Human Accession NM_025218.2

Human ULBP1 ORF Clone(NM_025218.2) - CDCR310342 from Creative Biomart Species Human Accession NM_025218.2

Human ULBP1 ORF Clone(NM_025218.2) - CDCR310343 from Creative Biomart Species Human Accession NM_025218.2

human ULBP1 ORF clone - CDCH098136 from Creative Biomart Species Human Accession NM_025218

human ULBP1 ORF clone - CDCH098137 from Creative Biomart Species Human Accession NM_025218

Human ULBP1 Gene ORF cDNA clone in cloning vector - HG10679-M from Sino Biological Species Human

Human ULBP1 Gene ORF cDNA clone expression plasmid, C-OFPSpark tag - HG10679-ACR from Sino Biological Species Human

Human ULBP1 Gene ORF cDNA clone expression plasmid, C-Flag tag - HG10679-M-F from Sino Biological Species Human

Human ULBP1 Gene ORF cDNA clone expression plasmid - HG10679-UT from Sino Biological Species Human

Human ULBP1 Gene ORF cDNA clone expression plasmid, N-His tag - HG10679-NH from Sino Biological Species Human

Human ULBP1 Gene ORF cDNA clone expression plasmid, N-Flag tag - HG10679-NF from Sino Biological Species Human

Human ULBP1 Gene ORF cDNA clone expression plasmid, N-Myc tag - HG10679-NM from Sino Biological Species Human

Human ULBP1 Gene ORF cDNA clone expression plasmid, C-HA tag - HG10679-CY from Sino Biological Species Human

Human ULBP1 Gene ORF cDNA clone expression plasmid, C-Flag tag - HG10679-CF from Sino Biological Species Human

Human ULBP1 Gene ORF cDNA clone expression plasmid, C-Myc tag - HG10679-CM from Sino Biological Species Human

Human ULBP-1 Gene cDNA Clone (full-length ORF Clone) expression ready, untagged - HG10679-M-N from Sino Biological Species Human Accession NM_025218.2

Human ULBP1 Gene ORF cDNA clone expression plasmid, N-HA tag - HG10679-NY from Sino Biological Species Human

Human ULBP1 Gene ORF cDNA clone expression plasmid, C-His tag - HG10679-CH from Sino Biological Species Human

Human ULBP1 Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - HG10679-ACG from Sino Biological Species Human

Human ULBP-1 ORF clone(NM_025218.2) - CDCL186684 from Creative biogene Species Human

Human ULBP1 cDNA Clone(NM_025218.2) - CDFG005003 from Creative biogene Species Human

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