ULBP1

Gene Symbol	ULBP1
Entrez Gene	80329
Alt Symbol	RAET1I
Species	Human
Gene Type	protein-coding
Description	UL16 binding protein 1
Other Description	N2DL-1|NKG2D ligand 1|NKG2DL1|UL16-binding protein 1|alcan-beta|retinoic acid early transcript 1I
Swissprots	Q8IZX6 Q9BZM6 Q8IZW3 Q5VY81
Accessions	EAW47776 Q9BZM6 AB052907 BAB61049 AF304377 AAK13081 AF346416 AAL76416 AF346595 AAN40838 AF425265 AAN32759 AK292519 BAF85208 AK316582 BAG38170 BC035416 AAH35416 NM_025218 NP_079494
Function	Ligand for the KLRK1/NKG2D receptor, together with at least ULBP2 and ULBP3. ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to KLRK1/NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction pathway. In CMV infected cells, interacts with soluble CMV glycoprotein UL16. The interaction with UL16 blocked the interaction with the KLRK1/NKG2D receptor, providing a mechanism by which CMV infected cells might escape the immune system. UL16 also causes ULBP1 to be retained in the ER and cis-Golgi apparatus so that it does not reach the cell surface. {ECO:0000269|PubMed:11777960}.
Subcellular Location	Cell membrane {ECO:0000269|PubMed:12782710}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:12782710}. Endoplasmic reticulum {ECO:0000269|PubMed:12782710}. Note=Detected intracellularly in the endoplasmic reticulum of CMV-infected fibroblasts.
Tissue Specificity	Expressed in T-cells, B-cells, erythroleukemia cell lines and in a wide range of tissues including heart, brain, lung, liver, testis, lymph node, thymus, tonsil and bone marrow. Also found in fetal heart, brain, lung and liver.
Top Pathways	Natural killer cell mediated cytotoxicity

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

ULBP1 (3F1) - sc-53131 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

ULBP1 (C-20) - sc-20568 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

ULBP1 (H-46) - sc-33564 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

ULBP1 (K-18) - sc-20567 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Anti-ULBP1 antibody - ab180899 from Abcam Prices $370.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-ULBP1 antibody - ab90039 from Abcam Prices $370.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-ULBP1 antibody - ab172768 from Abcam Prices $370.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-ULBP1 antibody [EPR7532(2)] - ab176566 from Abcam Prices $357.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EPR7532(2)

Anti-ULBP1 antibody [MM0592-10K10] - ab89929 from Abcam Prices $370.00 Sizes 50 µg Host Mouse Clonality Monoclonal Clone MM0592-10K10

Anti-ULBP1 Antibody (Internal) IHC-plus™ - LS-B10147 from LifeSpan Bioscience Host Rabbit Clonality Polyclonal

Anti-ULBP1 Antibody - LS-C155745 from LifeSpan Bioscience Prices $335.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-ULBP1 Antibody (N-Terminus) - LS-C111247 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

ULBP-1 Antibody (170818) [Unconjugated] - MAB1380 from Novus Biologicals Prices $99.00, $269.00, $699.00 Sizes 25 µg, 100 µg, 500 µg Host Mouse Clonality Monoclonal Clone 170818

ULBP-1 Antibody [Unconjugated] - AF1380 from Novus Biologicals Prices $99.00, $359.00 Sizes 25 µg, 100 µg Host Goat Clonality Polyclonal

ULBP-1 Antibody - NBP1-80856 from Novus Biologicals Prices $419.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

ULBP-1 Antibody - NBP1-59052 from Novus Biologicals Prices $139.00, $329.00 Sizes 20 µl, 100 µl Host Rabbit Clonality Polyclonal

ULBP-1 Antibody - NBP2-20808 from Novus Biologicals Prices $329.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

ULBP-1 Antibody (MM0592-10K10) - NBP2-11986 from Novus Biologicals Prices $349.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone MM0592-10K10

ULBP-1 Antibody [Biotin] - BAF1380 from Novus Biologicals Prices $390.00 Sizes 50 µg Host Goat Clonality Polyclonal

ULBP-1 Antibody (170818) [PerCP (Peridinin-chlorophyll Protein Complex)] - FAB1380C from Novus Biologicals Prices $359.00 Sizes 100 tests Host Mouse Clonality Monoclonal Clone 170818

ULBP-1 Antibody (170818) [Phycoerythrin] - FAB1380P from Novus Biologicals Prices $309.00 Sizes 100 tests Host Mouse Clonality Monoclonal Clone 170818

ULBP-1 Antibody (170818) [Alexa Fluor 488] - FAB1380G from Novus Biologicals Prices $329.00 Sizes 100 tests Host Mouse Clonality Monoclonal Clone 170818

ULBP-1 Antibody (170818) [Allophycocyanin] - FAB1380A from Novus Biologicals Prices $359.00 Sizes 100 tests Host Mouse Clonality Monoclonal Clone 170818

Rabbit Anti-ULBP1 Polyclonal Antibody - bs-2728R from Bioss Prices $245.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-ULBP1, (N-terminal) antibody produced in rabbit - SAB2103680 from Sigma-Aldrich Prices $347.50 Sizes 100 µl Host Rabbit Clonality Polyclonal

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