| Gene Symbol |
ULBP1
|
| Entrez Gene |
80329
|
| Alt Symbol |
RAET1I
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
UL16 binding protein 1
|
| Other Description |
N2DL-1|NKG2D ligand 1|NKG2DL1|UL16-binding protein 1|alcan-beta|retinoic acid early transcript 1I
|
| Swissprots |
Q8IZX6 Q9BZM6 Q8IZW3 Q5VY81
|
| Accessions |
EAW47776 Q9BZM6 AB052907 BAB61049 AF304377 AAK13081 AF346416 AAL76416 AF346595 AAN40838 AF425265 AAN32759 AK292519 BAF85208 AK316582 BAG38170 BC035416 AAH35416 NM_025218 NP_079494
|
| Function |
Ligand for the KLRK1/NKG2D receptor, together with at least ULBP2 and ULBP3. ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to KLRK1/NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction pathway. In CMV infected cells, interacts with soluble CMV glycoprotein UL16. The interaction with UL16 blocked the interaction with the KLRK1/NKG2D receptor, providing a mechanism by which CMV infected cells might escape the immune system. UL16 also causes ULBP1 to be retained in the ER and cis-Golgi apparatus so that it does not reach the cell surface. {ECO:0000269|PubMed:11777960}.
|
| Subcellular Location |
Cell membrane {ECO:0000269|PubMed:12782710}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:12782710}. Endoplasmic reticulum {ECO:0000269|PubMed:12782710}. Note=Detected intracellularly in the endoplasmic reticulum of CMV-infected fibroblasts.
|
| Tissue Specificity |
Expressed in T-cells, B-cells, erythroleukemia cell lines and in a wide range of tissues including heart, brain, lung, liver, testis, lymph node, thymus, tonsil and bone marrow. Also found in fetal heart, brain, lung and liver.
|
| Top Pathways |
Natural killer cell mediated cytotoxicity
|