ULBP1

Gene Symbol ULBP1
Entrez Gene 80329
Alt Symbol RAET1I
Species Human
Gene Type protein-coding
Description UL16 binding protein 1
Other Description N2DL-1|NKG2D ligand 1|NKG2DL1|UL16-binding protein 1|alcan-beta|retinoic acid early transcript 1I
Swissprots Q8IZX6 Q9BZM6 Q8IZW3 Q5VY81
Accessions EAW47776 Q9BZM6 AB052907 BAB61049 AF304377 AAK13081 AF346416 AAL76416 AF346595 AAN40838 AF425265 AAN32759 AK292519 BAF85208 AK316582 BAG38170 BC035416 AAH35416 NM_025218 NP_079494
Function Ligand for the KLRK1/NKG2D receptor, together with at least ULBP2 and ULBP3. ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to KLRK1/NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction pathway. In CMV infected cells, interacts with soluble CMV glycoprotein UL16. The interaction with UL16 blocked the interaction with the KLRK1/NKG2D receptor, providing a mechanism by which CMV infected cells might escape the immune system. UL16 also causes ULBP1 to be retained in the ER and cis-Golgi apparatus so that it does not reach the cell surface. {ECO:0000269|PubMed:11777960}.
Subcellular Location Cell membrane {ECO:0000269|PubMed:12782710}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:12782710}. Endoplasmic reticulum {ECO:0000269|PubMed:12782710}. Note=Detected intracellularly in the endoplasmic reticulum of CMV-infected fibroblasts.
Tissue Specificity Expressed in T-cells, B-cells, erythroleukemia cell lines and in a wide range of tissues including heart, brain, lung, liver, testis, lymph node, thymus, tonsil and bone marrow. Also found in fetal heart, brain, lung and liver.
Top Pathways Natural killer cell mediated cytotoxicity

ULBP1 CRISPR/Cas9 KO Plasmid (h) - sc-403835 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

ULBP1 HDR Plasmid (h) - sc-403835-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ULBP1 Double Nickase Plasmid (h) - sc-403835-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ULBP1 Double Nickase Plasmid (h2) - sc-403835-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ULBP1 CRISPR Activation Plasmid (h) - sc-403835-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

ULBP1 CRISPR Activation Plasmid (h2) - sc-403835-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

ULBP1 Lentiviral Activation Particles (h) - sc-403835-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ULBP1 Lentiviral Activation Particles (h2) - sc-403835-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ULBP1 siRNA (h) - sc-43005 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

ULBP1 shRNA Plasmid (h) - sc-43005-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

ULBP1 shRNA (h) Lentiviral Particles - sc-43005-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU107981 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN22483 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND22483 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR13236 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr13236

ULBP1 siRNA (Human) - CRJ2860 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

ULBP-1 RNAi - H00080329-R02 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

ULBP1 - MBS8210206 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human ULBP1(NM_025218.2) - SHL114138 from Creative biogene

Category siRNA
Species Reactivities Human

Human ULBP1 siRNA - orb273361 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

ULBP1 shRNA Plasmid (Human) - CHJ2860 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

ULBP1 miRNA 3'UTR clone - MiUTR1H-11001 from Creative biogene

Species Reactivities Human
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