ULBP1

Gene Symbol	ULBP1
Entrez Gene	80329
Alt Symbol	RAET1I
Species	Human
Gene Type	protein-coding
Description	UL16 binding protein 1
Other Description	N2DL-1|NKG2D ligand 1|NKG2DL1|UL16-binding protein 1|alcan-beta|retinoic acid early transcript 1I
Swissprots	Q8IZX6 Q9BZM6 Q8IZW3 Q5VY81
Accessions	EAW47776 Q9BZM6 AB052907 BAB61049 AF304377 AAK13081 AF346416 AAL76416 AF346595 AAN40838 AF425265 AAN32759 AK292519 BAF85208 AK316582 BAG38170 BC035416 AAH35416 NM_025218 NP_079494
Function	Ligand for the KLRK1/NKG2D receptor, together with at least ULBP2 and ULBP3. ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to KLRK1/NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction pathway. In CMV infected cells, interacts with soluble CMV glycoprotein UL16. The interaction with UL16 blocked the interaction with the KLRK1/NKG2D receptor, providing a mechanism by which CMV infected cells might escape the immune system. UL16 also causes ULBP1 to be retained in the ER and cis-Golgi apparatus so that it does not reach the cell surface. {ECO:0000269|PubMed:11777960}.
Subcellular Location	Cell membrane {ECO:0000269|PubMed:12782710}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:12782710}. Endoplasmic reticulum {ECO:0000269|PubMed:12782710}. Note=Detected intracellularly in the endoplasmic reticulum of CMV-infected fibroblasts.
Tissue Specificity	Expressed in T-cells, B-cells, erythroleukemia cell lines and in a wide range of tissues including heart, brain, lung, liver, testis, lymph node, thymus, tonsil and bone marrow. Also found in fetal heart, brain, lung and liver.
Top Pathways	Natural killer cell mediated cytotoxicity

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human ULBP1 full length protein - ab184592 from Abcam Category Protein Source E. coli Species Human

Human ULBP1 full length protein - ab134517 from Abcam Category Protein Source E. coli Species Human

ULBP1 Antibody Blocking Peptide - LS-E18034 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ULBP-1 Recombinant Protein - H00080329-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human ULBP-1 Protein - NBP2-22930 from Novus Biologicals Category Protein Prices $269.00 Sizes 100 µg Source E.coli Species Human

Recombinant Human ULBP-1 Fc Chimera, CF - 1380-UL-050 from R&D Systems Category Protein Source Spodoptera frugiperda, Sf 21 (stably transfected)-derived

Human ALCAN-beta protein - orb83638 from Biorbyt Category Protein Prices $400.00, $612.00 Sizes 50 μg, 100 μg Source Human Species Human

Human ALCAN-beta protein - orb83365 from Biorbyt Category Protein Prices $400.00, $612.00 Sizes 50 μg, 100 μg Source Human Species Human

ULBP1 Blocking Peptide - 33R-5583 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

ULBP1 protein (His tag) - 80R-2483 from Fitzgerald Category Protein Prices $270.00 Sizes 100 µg Source E.coli

ULBP1 / NKG2D ligand 1 (26-216, His-tag) - AR50555PU-N from Acris Antibodies Category Protein Prices $790.00 Sizes 500 µg Source E. coli Species Human

ULBP1 / NKG2D ligand 1 (26-216, His-tag) - AR50555PU-S from Acris Antibodies Category Protein Prices $340.00 Sizes 100 µg Source E. coli Species Human

ULBP1 / NKG2D ligand 1 - H00080329-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

ULBP1 / NKG2D ligand 1 - H00080329-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

ULBP1, 26-216aa, Human, His tag, E.coli - 01-P1731 from ARP American Research Products Category Protein Prices $179.00, $369.00, $849.00 Sizes 20 µg, 100 µg, 500 µg Species Human

ULBP1 fusion protein - Ag12079 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

ULBP1, 26-216aa , Human, His tag, E.coli - GWB-P0307H from Genway Biotech Category Protein Prices $300.00, $900.00 Sizes 100 μg, 500 μg Source E.coli Species Human

Recombinant Human ULBP1, His tagged - ULBP1-2352H from Creative Biomart Category Protein Source Human Cells Species Human

Recombinant Human ULBP1, Fc-His tagged - ULBP1-3249H from Creative Biomart Category Protein Source Human Cells Species Human

Recombinant Human UL16 Binding Protein 1, His-tagged - ULBP1-7163H from Creative Biomart Category Protein Source E. coli Species Human

Recombinant Human ULBP1, His-tagged - ULBP1-3591H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human ULBP1 - ULBP1-764H from Creative Biomart Category Protein Source Mammalian Cells Species Human

Human ULBP1 / N2DL1 Protein (His Tag) - 10679-H08H-50 from Sino Biological Category Protein Prices $178.00, $178.00 Sizes 50 µg, 100 µg Source Human Cells Species Human

Human ULBP1 / RAET1 / N2DL1 Protein (His & Fc Tag) - 10679-H03H-50 from Sino Biological Category Protein Prices $178.00, $178.00 Sizes 50 µg, 100 µg Source Human Cells Species Human

Recombinant Human NKG2D ligand 1(ULBP1) - CSB-YP887177HU CSB-EP887177HU CSB-BP887177HU CSB-MP887177HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

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