CLK2
| Gene Symbol | CLK2 |
|---|---|
| Entrez Gene | 1196 |
| Alt Symbol | - |
| Species | Human |
| Gene Type | protein-coding |
| Description | CDC-like kinase 2 |
| Other Description | CLK kinase|dual specificity protein kinase CLK2 |
| Swissprots | Q96CQ0 B5MBX6 B1AVS9 P49760 |
| Accessions | AAC51817 CBX51409 EAW53087 EAW53088 EAW53089 P49760 AK091036 BAG52265 AK291995 BAF84684 AK303696 BAH14022 AU136826 BC006274 AAH06274 BC014067 AAH14067 BC053603 AAH53603 BI562223 HY049688 L29216 AAA61481 L29218 AAA61482 XM_005244878 XP_005244935 XM_005276744 XP_005276801 XM_011509143 XP_011507445 XM_011509144 XP_011507446 XM_011509145 XP_011507447 XM_011509146 XP_011507448 XM_011509147 XP_011507449 XM_011546925 XP_011545227 XM_011546926 XP_011545228 XM_011546927 XP_011545229 XM_011546928 XP_011545230 XM_011546929 XP_011545231 XR_241067 XR_254196 NM_001294338 NP_001281267 NM_001294339 NP_001281268 NM_003993 NP_003984 NM_001291 |
| Function | Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing and can cause redistribution of SR proteins from speckles to a diffuse nucleoplasmic distribution. Acts as a suppressor of hepatic gluconeogenesis and glucose output by repressing PPARGC1A transcriptional activity on gluconeogenic genes via its phosphorylation. Phosphorylates PPP2R5B thereby stimulating the assembly of PP2A phosphatase with the PPP2R5B-AKT1 complex leading to dephosphorylation of AKT1. Phosphorylates: PTPN1, SRSF1 and SRSF3. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells. {ECO:0000269|PubMed:10480872, ECO:0000269|PubMed:19168442, ECO:0000269|PubMed:8910305, ECO:0000269|PubMed:9637771}. |
| Subcellular Location | Isoform 1: Nucleus. Nucleus speckle. Note=Inhibition of phosphorylation at Ser-142 results in accumulation in the nuclear speckle. {ECO:0000250}. |
| Tissue Specificity | Endothelial cells. {ECO:0000269|PubMed:19168442}. |
CLK2 (F-4) - sc-393909 from Santa Cruz Biotechnology
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CLK2 (D-16) - sc-74912 from Santa Cruz Biotechnology
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CLK2 (H-300) - sc-292184 from Santa Cruz Biotechnology
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CLK2 (S-15) - sc-74914 from Santa Cruz Biotechnology
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CLK2 (Y-15) - sc-74915 from Santa Cruz Biotechnology
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Anti-CLK2 antibody - ab86147 from Abcam
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Anti-CLK2 antibody - ab65082 from Abcam
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Anti-CLK2 antibody - ab188141 from Abcam
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Anti-CLK2 antibody - ab130716 from Abcam
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Anti-CLK2 Antibody (N-Terminus) - LS-C99887 from LifeSpan Bioscience
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Anti-CLK2 Antibody (N-Terminus) - LS-C327089 from LifeSpan Bioscience
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Anti-CLK2 Antibody (aa290-319) - LS-C320448 from LifeSpan Bioscience
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Anti-CLK2 Antibody (aa51-100) - LS-C201599 from LifeSpan Bioscience
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Anti-CLK2 Antibody (aa65-93) - LS-C320450 from LifeSpan Bioscience
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Anti-CLK2 Antibody (aa290-319) - LS-C168844 from LifeSpan Bioscience
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Anti-CLK2 Antibody (C-Terminus) - LS-C345496 from LifeSpan Bioscience
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Anti-CLK2 Antibody (aa65-93) - LS-C164347 from LifeSpan Bioscience
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Anti-CLK2 Antibody (aa290-319, FITC) - LS-C255044 from LifeSpan Bioscience
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Anti-CLK2 Antibody (aa290-319, APC) - LS-C255042 from LifeSpan Bioscience
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Anti-CLK2 Antibody (aa290-319, Biotin) - LS-C255043 from LifeSpan Bioscience
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Anti-CLK2 Antibody (aa290-319, AP) - LS-C255041 from LifeSpan Bioscience
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Anti-CLK2 Antibody (aa290-319, PE) - LS-C255045 from LifeSpan Bioscience
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Anti-CLK2 Antibody (Arg15) - LS-C191967 from LifeSpan Bioscience
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Anti-CLK2 Antibody (aa290-319, Azide-free, HRP) - LS-C255047 from LifeSpan Bioscience
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Anti-CLK2 Antibody (aa65-93, AP) - LS-C255046 from LifeSpan Bioscience
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