| Gene Symbol |
CLK2
|
| Entrez Gene |
1196
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
CDC-like kinase 2
|
| Other Description |
CLK kinase|dual specificity protein kinase CLK2
|
| Swissprots |
Q96CQ0 B5MBX6 B1AVS9 P49760
|
| Accessions |
AAC51817 CBX51409 EAW53087 EAW53088 EAW53089 P49760 AK091036 BAG52265 AK291995 BAF84684 AK303696 BAH14022 AU136826 BC006274 AAH06274 BC014067 AAH14067 BC053603 AAH53603 BI562223 HY049688 L29216 AAA61481 L29218 AAA61482 XM_005244878 XP_005244935 XM_005276744 XP_005276801 XM_011509143 XP_011507445 XM_011509144 XP_011507446 XM_011509145 XP_011507447 XM_011509146 XP_011507448 XM_011509147 XP_011507449 XM_011546925 XP_011545227 XM_011546926 XP_011545228 XM_011546927 XP_011545229 XM_011546928 XP_011545230 XM_011546929 XP_011545231 XR_241067 XR_254196 NM_001294338 NP_001281267 NM_001294339 NP_001281268 NM_003993 NP_003984 NM_001291
|
| Function |
Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing and can cause redistribution of SR proteins from speckles to a diffuse nucleoplasmic distribution. Acts as a suppressor of hepatic gluconeogenesis and glucose output by repressing PPARGC1A transcriptional activity on gluconeogenic genes via its phosphorylation. Phosphorylates PPP2R5B thereby stimulating the assembly of PP2A phosphatase with the PPP2R5B-AKT1 complex leading to dephosphorylation of AKT1. Phosphorylates: PTPN1, SRSF1 and SRSF3. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells. {ECO:0000269|PubMed:10480872, ECO:0000269|PubMed:19168442, ECO:0000269|PubMed:8910305, ECO:0000269|PubMed:9637771}.
|
| Subcellular Location |
Isoform 1: Nucleus. Nucleus speckle. Note=Inhibition of phosphorylation at Ser-142 results in accumulation in the nuclear speckle. {ECO:0000250}.
|
| Tissue Specificity |
Endothelial cells. {ECO:0000269|PubMed:19168442}.
|