CLK2

Gene Symbol	CLK2
Entrez Gene	1196
Alt Symbol	-
Species	Human
Gene Type	protein-coding
Description	CDC-like kinase 2
Other Description	CLK kinase|dual specificity protein kinase CLK2
Swissprots	Q96CQ0 B5MBX6 B1AVS9 P49760
Accessions	AAC51817 CBX51409 EAW53087 EAW53088 EAW53089 P49760 AK091036 BAG52265 AK291995 BAF84684 AK303696 BAH14022 AU136826 BC006274 AAH06274 BC014067 AAH14067 BC053603 AAH53603 BI562223 HY049688 L29216 AAA61481 L29218 AAA61482 XM_005244878 XP_005244935 XM_005276744 XP_005276801 XM_011509143 XP_011507445 XM_011509144 XP_011507446 XM_011509145 XP_011507447 XM_011509146 XP_011507448 XM_011509147 XP_011507449 XM_011546925 XP_011545227 XM_011546926 XP_011545228 XM_011546927 XP_011545229 XM_011546928 XP_011545230 XM_011546929 XP_011545231 XR_241067 XR_254196 NM_001294338 NP_001281267 NM_001294339 NP_001281268 NM_003993 NP_003984 NM_001291
Function	Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing and can cause redistribution of SR proteins from speckles to a diffuse nucleoplasmic distribution. Acts as a suppressor of hepatic gluconeogenesis and glucose output by repressing PPARGC1A transcriptional activity on gluconeogenic genes via its phosphorylation. Phosphorylates PPP2R5B thereby stimulating the assembly of PP2A phosphatase with the PPP2R5B-AKT1 complex leading to dephosphorylation of AKT1. Phosphorylates: PTPN1, SRSF1 and SRSF3. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells. {ECO:0000269|PubMed:10480872, ECO:0000269|PubMed:19168442, ECO:0000269|PubMed:8910305, ECO:0000269|PubMed:9637771}.
Subcellular Location	Isoform 1: Nucleus. Nucleus speckle. Note=Inhibition of phosphorylation at Ser-142 results in accumulation in the nuclear speckle. {ECO:0000250}.
Tissue Specificity	Endothelial cells. {ECO:0000269|PubMed:19168442}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human CLK2 protein fragment - ab63190 from Abcam Category Protein Prices $294.00 Sizes 10 µg Source Baculovirus infected sf9 cells Species Human

Human CLK2 full length protein - ab132694 from Abcam Category Protein Source Wheat germ Species Human

Human CLK2 peptide - ab99082 from Abcam Category Peptide

Human CLK2 protein fragment - ab152285 from Abcam Category Protein Source Wheat germ Species Human

CLK2-Antibody-Center-Blocking-Peptide - BP16732c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

CLK2-Antibody-N-term-Blocking-Peptide - BP7530a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

CLK2 peptide - orb217107 from Biorbyt Category Peptide Prices $272.00, $510.00 Sizes 1 mg, 5 mg

CLK2 - H00001196-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

CLK2 - H00001196-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

CLK2 - H00001196-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

CLK2 - H00001196-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

CLK2 - P5528 from Acris Antibodies Category Protein Prices $840.00 Sizes 5 µg Species Human

CLK2 fusion protein - ag1549 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human CDC-like Kinase 2, GST-tagged, Active - CLK2-285H from Creative Biomart Category Protein Source Sf9 insect cells using baculovirus.

Recombinant Human CLK2, GST-tagged - CLK2-11334H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human CDC-Like Kinase 2, GST-tagged - CLK2-1005H from Creative Biomart Category Protein Species Human

CLK2 Protein, active, 10 µg - 14-774 from EMD Millipore Category Protein Prices $329.00 Sizes 10 µg also available in 250 µg size --call for pricing and availability and reference catalog numbe Source Expressed by baculovirus in Sf21 insect cells.

CLK2 Protein, active, 250 µg - 14-774M from EMD Millipore Category Protein Prices $2,544.00 Sizes 250 µg also available in 10 μg size . (cat#14-774) and in bulk (cat# 14-774-K) Source Expressed by baculovirus in Sf21 insect cells.

CLK2 Blocking Peptide - CBP1244 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Monkey

CLK2 (R15) Peptide - BS2005P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

Recombinant Human Dual specificity protein kinase CLK2(CLK2) - CSB-YP005558HU CSB-EP005558HU CSB-BP005558HU CSB-MP005558HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

CLK2 Protein - abx163442 from Abbexa Category Protein Species Human, Mouse, Rat

Dual specificity protein kinase CLK2 (CLK2), Recombinant Protein - MBS952492 from MyBioSource Category Protein Prices $1,285.00, $1,285.00, $1,505.00, $1,505.00, $2,110.00, $2,110.00, $2,575.00, $2,575.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

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