CLK2

Gene Symbol CLK2
Entrez Gene 1196
Alt Symbol -
Species Human
Gene Type protein-coding
Description CDC-like kinase 2
Other Description CLK kinase|dual specificity protein kinase CLK2
Swissprots Q96CQ0 B5MBX6 B1AVS9 P49760
Accessions AAC51817 CBX51409 EAW53087 EAW53088 EAW53089 P49760 AK091036 BAG52265 AK291995 BAF84684 AK303696 BAH14022 AU136826 BC006274 AAH06274 BC014067 AAH14067 BC053603 AAH53603 BI562223 HY049688 L29216 AAA61481 L29218 AAA61482 XM_005244878 XP_005244935 XM_005276744 XP_005276801 XM_011509143 XP_011507445 XM_011509144 XP_011507446 XM_011509145 XP_011507447 XM_011509146 XP_011507448 XM_011509147 XP_011507449 XM_011546925 XP_011545227 XM_011546926 XP_011545228 XM_011546927 XP_011545229 XM_011546928 XP_011545230 XM_011546929 XP_011545231 XR_241067 XR_254196 NM_001294338 NP_001281267 NM_001294339 NP_001281268 NM_003993 NP_003984 NM_001291
Function Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing and can cause redistribution of SR proteins from speckles to a diffuse nucleoplasmic distribution. Acts as a suppressor of hepatic gluconeogenesis and glucose output by repressing PPARGC1A transcriptional activity on gluconeogenic genes via its phosphorylation. Phosphorylates PPP2R5B thereby stimulating the assembly of PP2A phosphatase with the PPP2R5B-AKT1 complex leading to dephosphorylation of AKT1. Phosphorylates: PTPN1, SRSF1 and SRSF3. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells. {ECO:0000269|PubMed:10480872, ECO:0000269|PubMed:19168442, ECO:0000269|PubMed:8910305, ECO:0000269|PubMed:9637771}.
Subcellular Location Isoform 1: Nucleus. Nucleus speckle. Note=Inhibition of phosphorylation at Ser-142 results in accumulation in the nuclear speckle. {ECO:0000250}.
Tissue Specificity Endothelial cells. {ECO:0000269|PubMed:19168442}.

CLK2-Over-expression-Lysate - LY10426a from Abgent, a WuXi AppTec company

Category Cell Lysate
Prices $325.00
Sizes 100 µg
Western blot analysis of his-tag CLK2 (arrow) using his tag antibody. 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the CLK2 gene

CLK2 overexpression lysate - LY401307 from Acris Antibodies

Category Cell Lysate
Prices $280.00
Sizes 100 µg

CLK2 293 Cell Lysate - 401199 from ABBIOTEC

Category Cell Lysate
Prices $392.00
Sizes 100 µg

CLK2 Overexpression Lysate (Native) - NBL1-09274 from Novus Biologicals

Category Cell Lysate
Prices $329.00
Sizes 100 µg
Western Blot: CLK2 Overexpression Lysate (Adult Normal) [NBL1-09274] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for CLK2.

CLK2 (h): 293T Lysate - sc-116461 from Santa Cruz Biotechnology

Category Cell Lysate
Prices $205.00
Sizes 100 µg/200 µl
Species Human

CLK2 Over-expression Lysate Product - GWB-DBA008 from Genway Biotech

Category Cell Lysate
Prices $346.00
Sizes 100 µg
Species Human

CLK2 Overexpression Lysate (Denatured) - H00001196-T02 from Novus Biologicals

Category Cell Lysate
Prices $279.00
Sizes 100 µl

Panoply™ Human CLK2 Knockdown Stable Cell Line - CSC-DC003293 from Creative biogene

Category Cell Line
Species Human
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