CLK2

Gene Symbol CLK2
Entrez Gene 1196
Alt Symbol -
Species Human
Gene Type protein-coding
Description CDC-like kinase 2
Other Description CLK kinase|dual specificity protein kinase CLK2
Swissprots Q96CQ0 B5MBX6 B1AVS9 P49760
Accessions AAC51817 CBX51409 EAW53087 EAW53088 EAW53089 P49760 AK091036 BAG52265 AK291995 BAF84684 AK303696 BAH14022 AU136826 BC006274 AAH06274 BC014067 AAH14067 BC053603 AAH53603 BI562223 HY049688 L29216 AAA61481 L29218 AAA61482 XM_005244878 XP_005244935 XM_005276744 XP_005276801 XM_011509143 XP_011507445 XM_011509144 XP_011507446 XM_011509145 XP_011507447 XM_011509146 XP_011507448 XM_011509147 XP_011507449 XM_011546925 XP_011545227 XM_011546926 XP_011545228 XM_011546927 XP_011545229 XM_011546928 XP_011545230 XM_011546929 XP_011545231 XR_241067 XR_254196 NM_001294338 NP_001281267 NM_001294339 NP_001281268 NM_003993 NP_003984 NM_001291
Function Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing and can cause redistribution of SR proteins from speckles to a diffuse nucleoplasmic distribution. Acts as a suppressor of hepatic gluconeogenesis and glucose output by repressing PPARGC1A transcriptional activity on gluconeogenic genes via its phosphorylation. Phosphorylates PPP2R5B thereby stimulating the assembly of PP2A phosphatase with the PPP2R5B-AKT1 complex leading to dephosphorylation of AKT1. Phosphorylates: PTPN1, SRSF1 and SRSF3. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells. {ECO:0000269|PubMed:10480872, ECO:0000269|PubMed:19168442, ECO:0000269|PubMed:8910305, ECO:0000269|PubMed:9637771}.
Subcellular Location Isoform 1: Nucleus. Nucleus speckle. Note=Inhibition of phosphorylation at Ser-142 results in accumulation in the nuclear speckle. {ECO:0000250}.
Tissue Specificity Endothelial cells. {ECO:0000269|PubMed:19168442}.

Human-CLK2-cDNA-Clone - DC03748 from Abgent, a WuXi AppTec company

Prices $673.65
Sizes 10 µg
Species Human
Accession BC053603

CLK2 - MBS1274704 from MyBioSource

Prices $175.00
Sizes 10ug plasmid + 200ul glycerol stock
Species Human
Accession BC053603

CLK2 - MBS1268460 from MyBioSource

Prices $175.00
Sizes 10ug plasmid + 200ul glycerol stock
Species Human
Accession BC014067

Human CLK2 cDNA clone(NM_003993.2) - CDFH003864 from Creative Biomart

Species Human
Accession NM_003993.2

Human CLK2 cDNA clone(NM_003993.2) - CDFH003865 from Creative Biomart

Species Human
Accession NM_003993.2

Human CLK2 ORF clone(NM_003993.2) - CDCL183625 from Creative Biomart

Species Human
Accession NM_003993.2

Human CLK2 ORF Clone(NM_003993.2) - CDCR286968 from Creative Biomart

Species Human
Accession NM_003993.2

Human CLK2 ORF Clone(NM_003993.2) - CDCR286969 from Creative Biomart

Species Human
Accession NM_003993.2

Human CLK2 ORF Clone(NM_003993.2) - CDCL159100 from Creative Biomart

Species Human
Accession NM_003993.2

Human CLK2 ORF Clone(NM_003993.2) - CDCL159101 from Creative Biomart

Species Human
Accession NM_003993.2

Human CLK2 ORF clone(NM_003993.2) - CDCL183625 from Creative biogene

Species Human

Human CLK2 ORF Clone (BC014067) - CDCS411573 from Creative biogene

Species Human
Accession P49760

Human CLK2 ORF Clone (BC053603) - CDCS411574 from Creative biogene

Species Human
Accession P49760

Human CLK2 cDNA Clone(NM_003993.2) - CDFH003864 from Creative biogene

Species Human

Human CLK2 cDNA Clone(NM_003993.2) - CDFH003865 from Creative biogene

Species Human
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