IDE

Gene Symbol	IDE
Entrez Gene	3416
Alt Symbol	INSULYSIN
Species	Human
Gene Type	protein-coding
Description	insulin-degrading enzyme
Other Description	Abeta-degrading protease|insulin protease|insulinase
Swissprots	Q5T5N2 P14735 B7ZAU2 B2R721 D3DR35
Accessions	CBA13324 EAW50090 EAW50091 EAW50092 EAW50093 P14735 AB209204 BAD92441 AK093287 BAG52680 AK302578 BAH13752 AK312810 BAG35668 AK316407 BAH14778 BC036188 BC096336 AAH96336 BC096337 AAH96337 BC096338 BC096339 AAH96339 BX648462 CF780766 CK824565 DA643304 DA879845 DB204538 DB219527 DB445060 M21188 AAA52712 XM_005269766 XP_005269823 XM_005269769 XP_005269826 XR_945727 NM_001165946 NP_001159418 NM_004969 NP_004960
Function	Plays a role in the cellular breakdown of insulin, IAPP, glucagon, bradykinin, kallidin and other peptides, and thereby plays a role in intercellular peptide signaling. Degrades amyloid formed by APP and IAPP. May play a role in the degradation and clearance of naturally secreted amyloid beta-protein by neurons and microglia. {ECO:0000269|PubMed:10684867, ECO:0000269|PubMed:17613531, ECO:0000269|PubMed:18986166}.
Subcellular Location	Cytoplasm. Cell membrane. Secreted {ECO:0000250}. Note=Present at the cell surface of neuron cells. The membrane-associated isoform is approximately 5 kDa larger than the known cytosolic isoform.
Top Pathways	Alzheimer's disease

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Mouse IDE ELISA Kit (Sandwich ELISA) - LS-F5702 from LifeSpan Bioscience Category ELISA Kit Prices $700.00 Sizes 1 plate Sensitivity 0.156 ng/ml Range 0.156-10 ng/ml

Human IDE ELISA Kit (Sandwich ELISA) - LS-F6210 from LifeSpan Bioscience Category ELISA Kit Prices $690.00 Sizes 1 plate Sensitivity 0.313 ng/ml Range 0.156-10 ng/ml

Rat IDE ELISA Kit (Sandwich ELISA) - LS-F7574 from LifeSpan Bioscience Category ELISA Kit Prices $740.00 Sizes 1 plate Sensitivity 0.125 ng/ml Range 0.156-10 ng/ml

Mouse IDE ELISA Kit (Sandwich ELISA) - LS-F11706 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 0.312 Range 0.156-10 ng/ml

Human IDE ELISA Kit (Sandwich ELISA) - LS-F11707 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 0.156 Range 0.156-10 ng/ml

Human IDE ELISA Kit - abx151897 from Abbexa Category ELISA Kit Sensitivity 22.7 pg/ml Range 62.5 pg/ml - 4000 pg/ml

Insulin Degrading Enzyme, IDE, Human, ELISA Kit - E-EL-H0429 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t Sensitivity 37.5 Range 62.5-4000pg/mL

Insulin Degrading Enzyme (IDE), Human, ELISA Kit - SEB897Hu from ARP American Research Products Category ELISA Kit Prices $685.00 Sizes 96 t Sensitivity 22.7pg/mL Range 62.5-4,000pg/mL

Insulin-degrading Enzyme (IDE), Human, ELISA Kit - CSB-E13349h from ARP American Research Products Category ELISA Kit Prices $550.00, $790.00, $791.00, $794.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t

Insulin-degrading enzyme, Human, ELISA Kit - E01I0332 from ARP American Research Products Category ELISA Kit Prices $535.00, $735.00 Sizes 48 t, 96 t Sensitivity 1.0pg/ml Range 250-5000pg/mL,

Insulin-degrading enzyme, IDE, Human, ELISA Kit - E1897h from ARP American Research Products Category ELISA Kit Prices $596.00 Sizes 96 t Range 0.156-10 ng/mL

Insulin Degrading Enzyme, IDE, Rabbit, ELISA Kit - E-EL-RB2162 from ARP American Research Products Category ELISA Kit Prices $648.00 Sizes 96 t

Insulin Degrading Enzyme, IDE, Chicken, ELISA Kit - E-EL-Ch0267 from ARP American Research Products Category ELISA Kit Prices $445.50 Sizes 96 t

Insulin Degrading Enzyme, IDE, Porcine, ELISA Kit - E-EL-P1005 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Insulin Degrading Enzyme, IDE, Guinea Pig, ELISA Kit - E-EL-GP0956 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t

Insulin Degrading Enzyme, IDE, Monkey, ELISA Kit - E-EL-MK1038 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Human IDE ELISA Kit - HI0339 from NeoScientific Category ELISA Kit Prices $495.00 Sizes 96 t

Anserine IDE ELISA Kit - AI0339 from NeoScientific Category ELISA Kit Prices $495.00 Sizes 96 t

Human IDE(Insulin Degrading Enzyme) ELISA Kit - E-EL-H0429 from Elabscience Category ELISA Kit Sensitivity 37.50 pg/mL Range 62.50—4000 pg/mL

Human IDE (Insulin Degrading Enzyme) CLIA Kit - E-CL-H0349 from Elabscience Category CLIA Kit Sensitivity 9.38 pg/mL Range Average Recovery (%)

IDE, ELISA Kit - MBS2513196 from MyBioSource Category ELISA Kit Prices $450.00, $535.00, $2,255.00, $3,975.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.375ng/mL Range 0.625-40ng/mL

IDE, ELISA Kit - MBS2504004 from MyBioSource Category ELISA Kit Prices $450.00, $535.00, $2,255.00, $3,975.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 1.875ng/mL Range 3.125-200ng/mL

IDE, ELISA Kit - MBS2509139 from MyBioSource Category ELISA Kit Prices $410.00, $490.00, $2,040.00, $3,590.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 37.5pg/mL Range 62.5--4000pg/mL

IDE, ELISA Kit - MBS2516115 from MyBioSource Category ELISA Kit Prices $410.00, $490.00, $2,040.00, $3,590.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.188ng/mL Range 0.313-20ng/mL

IDE, ELISA Kit - MBS2511308 from MyBioSource Category ELISA Kit Prices $450.00, $535.00, $2,255.00, $3,975.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 37.5pg/mL Range 62.5-4000pg/mL

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