IDE

Gene Symbol	IDE
Entrez Gene	3416
Alt Symbol	INSULYSIN
Species	Human
Gene Type	protein-coding
Description	insulin-degrading enzyme
Other Description	Abeta-degrading protease|insulin protease|insulinase
Swissprots	Q5T5N2 P14735 B7ZAU2 B2R721 D3DR35
Accessions	CBA13324 EAW50090 EAW50091 EAW50092 EAW50093 P14735 AB209204 BAD92441 AK093287 BAG52680 AK302578 BAH13752 AK312810 BAG35668 AK316407 BAH14778 BC036188 BC096336 AAH96336 BC096337 AAH96337 BC096338 BC096339 AAH96339 BX648462 CF780766 CK824565 DA643304 DA879845 DB204538 DB219527 DB445060 M21188 AAA52712 XM_005269766 XP_005269823 XM_005269769 XP_005269826 XR_945727 NM_001165946 NP_001159418 NM_004969 NP_004960
Function	Plays a role in the cellular breakdown of insulin, IAPP, glucagon, bradykinin, kallidin and other peptides, and thereby plays a role in intercellular peptide signaling. Degrades amyloid formed by APP and IAPP. May play a role in the degradation and clearance of naturally secreted amyloid beta-protein by neurons and microglia. {ECO:0000269|PubMed:10684867, ECO:0000269|PubMed:17613531, ECO:0000269|PubMed:18986166}.
Subcellular Location	Cytoplasm. Cell membrane. Secreted {ECO:0000250}. Note=Present at the cell surface of neuron cells. The membrane-associated isoform is approximately 5 kDa larger than the known cytosolic isoform.
Top Pathways	Alzheimer's disease

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

IDE - MBS1276552 from MyBioSource Prices $175.00 Sizes 10ug plasmid + 200ul glycerol stock Species Human Accession BC096336

Human Insulysin/insulin-degrading enzyme Gene ORF cDNA clone in cloning vector - HG15978-G from Sino Biological Species Human

Human Insulysin/insulin-degrading enzyme Gene ORF cDNA clone expression plasmid - HG15978-UT from Sino Biological Species Human

Human Insulysin/insulin-degrading enzyme Gene ORF cDNA clone expression plasmid, C-Flag tag - HG15978-CF from Sino Biological Species Human

Human Insulysin/insulin-degrading enzyme Gene ORF cDNA clone expression plasmid, N-Myc tag - HG15978-NM from Sino Biological Species Human

Human Insulysin/insulin-degrading enzyme Gene ORF cDNA clone expression plasmid, C-Myc tag - HG15978-CM from Sino Biological Species Human

Human Insulysin/insulin-degrading enzyme Gene ORF cDNA clone expression plasmid, C-HA tag - HG15978-CY from Sino Biological Species Human

Human Insulysin/insulin-degrading enzyme Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - HG15978-ACG from Sino Biological Species Human

Human Insulysin/insulin-degrading enzyme Gene ORF cDNA clone expression plasmid, C-OFPSpark tag - HG15978-ACR from Sino Biological Species Human

Human Insulysin/insulin-degrading enzyme Gene ORF cDNA clone expression plasmid, N-HA tag - HG15978-NY from Sino Biological Species Human

Human Insulysin/insulin-degrading enzyme Gene ORF cDNA clone expression plasmid, N-His tag - HG15978-NH from Sino Biological Species Human

Human Insulysin/insulin-degrading enzyme Gene ORF cDNA clone expression plasmid, C-His tag - HG15978-CH from Sino Biological Species Human

Human Insulysin/insulin-degrading enzyme Gene ORF cDNA clone expression plasmid, N-Flag tag - HG15978-NF from Sino Biological Species Human

Mouse IDE ORF clone (NM_001165946.1) - CDCL119231 from Creative biogene Species Human

Human IDE ORF Clone (BC096336) - CDCS408797 from Creative biogene Species Human Accession P14735

Human IDE ORF clone (BC096336) - CDCB157603 from Creative biogene Species Human

Search more