IDE

Gene Symbol IDE
Entrez Gene 3416
Alt Symbol INSULYSIN
Species Human
Gene Type protein-coding
Description insulin-degrading enzyme
Other Description Abeta-degrading protease|insulin protease|insulinase
Swissprots Q5T5N2 P14735 B7ZAU2 B2R721 D3DR35
Accessions CBA13324 EAW50090 EAW50091 EAW50092 EAW50093 P14735 AB209204 BAD92441 AK093287 BAG52680 AK302578 BAH13752 AK312810 BAG35668 AK316407 BAH14778 BC036188 BC096336 AAH96336 BC096337 AAH96337 BC096338 BC096339 AAH96339 BX648462 CF780766 CK824565 DA643304 DA879845 DB204538 DB219527 DB445060 M21188 AAA52712 XM_005269766 XP_005269823 XM_005269769 XP_005269826 XR_945727 NM_001165946 NP_001159418 NM_004969 NP_004960
Function Plays a role in the cellular breakdown of insulin, IAPP, glucagon, bradykinin, kallidin and other peptides, and thereby plays a role in intercellular peptide signaling. Degrades amyloid formed by APP and IAPP. May play a role in the degradation and clearance of naturally secreted amyloid beta-protein by neurons and microglia. {ECO:0000269|PubMed:10684867, ECO:0000269|PubMed:17613531, ECO:0000269|PubMed:18986166}.
Subcellular Location Cytoplasm. Cell membrane. Secreted {ECO:0000250}. Note=Present at the cell surface of neuron cells. The membrane-associated isoform is approximately 5 kDa larger than the known cytosolic isoform.
Top Pathways Alzheimer's disease

IDE CRISPR/Cas9 KO Plasmid (h) - sc-401900 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

IDE HDR Plasmid (h) - sc-401900-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

IDE Double Nickase Plasmid (h) - sc-401900-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

IDE Double Nickase Plasmid (h2) - sc-401900-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

IDE CRISPR Activation Plasmid (h) - sc-401900-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

IDE CRISPR Activation Plasmid (h2) - sc-401900-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

IDE Lentiviral Activation Particles (h) - sc-401900-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

IDE Lentiviral Activation Particles (h2) - sc-401900-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

IDE siRNA (h) - sc-106817 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

IDE shRNA Plasmid (h) - sc-106817-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

IDE shRNA (h) Lentiviral Particles - sc-106817-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Insulysin/IDE RNAi - H00003416-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU049981 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN2251 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR05528 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr05528

IDE siRNA (Human) - CRH2311 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

IDE - MBS8221853 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human Ide (NM_004969.3) - SHH316545 from Creative biogene

Category siRNA
Species Reactivities Human

Human IDE siRNA - orb262813 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

IDE shRNA Plasmid (Human) - CHH2311 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

IDE miRNA 3'UTR clone - MiUTR4H-TG11480 from Creative biogene

Species Reactivities Human
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