IDE

Gene Symbol IDE
Entrez Gene 3416
Alt Symbol INSULYSIN
Species Human
Gene Type protein-coding
Description insulin-degrading enzyme
Other Description Abeta-degrading protease|insulin protease|insulinase
Swissprots Q5T5N2 P14735 B7ZAU2 B2R721 D3DR35
Accessions CBA13324 EAW50090 EAW50091 EAW50092 EAW50093 P14735 AB209204 BAD92441 AK093287 BAG52680 AK302578 BAH13752 AK312810 BAG35668 AK316407 BAH14778 BC036188 BC096336 AAH96336 BC096337 AAH96337 BC096338 BC096339 AAH96339 BX648462 CF780766 CK824565 DA643304 DA879845 DB204538 DB219527 DB445060 M21188 AAA52712 XM_005269766 XP_005269823 XM_005269769 XP_005269826 XR_945727 NM_001165946 NP_001159418 NM_004969 NP_004960
Function Plays a role in the cellular breakdown of insulin, IAPP, glucagon, bradykinin, kallidin and other peptides, and thereby plays a role in intercellular peptide signaling. Degrades amyloid formed by APP and IAPP. May play a role in the degradation and clearance of naturally secreted amyloid beta-protein by neurons and microglia. {ECO:0000269|PubMed:10684867, ECO:0000269|PubMed:17613531, ECO:0000269|PubMed:18986166}.
Subcellular Location Cytoplasm. Cell membrane. Secreted {ECO:0000250}. Note=Present at the cell surface of neuron cells. The membrane-associated isoform is approximately 5 kDa larger than the known cytosolic isoform.
Top Pathways Alzheimer's disease

IDE (E-4) - sc-514458 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
IDE (E-4): sc-514458. Western blot analysis of IDE expression in Hep G2 (A), IMR-32 (B), SK-N-SH (C), MES-SA/Dx5 (D) and A-375 (E) whole cell lysates.

IDE (A-23) - sc-130784 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
IDE (A-23): sc-130784. Immunoperoxidase staining of formalin-fixed, paraffin-embedded human hepatocarcinoma tissue showing cytoplasmic localization.

IDE (F-9) - sc-393887 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
IDE (F-9): sc-393887. Immunofluorescence staining of methanol-fixed HeLa cells showing cytoplasmic localization.

IDE (K-20) - sc-27266 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
IDE (K-20): sc-27266. Immunoperoxidase staining of formalin fixed, paraffin-embedded human duodenum tissue showing cytoplasmic and perinuclear staining of glandular cells.

IDE (N-15) - sc-27265 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
IDE (N-15): sc-27265. Western blot analysis of IDE expression in Hep G2 (A), SK-N-SH (B) and IMR-32 (C) whole cell lysates.

Anti-Insulin degrading enzyme / IDE antibody - ab32216 from Abcam

Prices $398.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Insulin degrading enzyme / IDE antibody (ab32216) at 1 µg/mlLane 1 : Mouse Brain at 20 µg/mlLane 2 : Brain (Rat) Whole Cell Lysate - normal tissue at 20 µgLane 3 : Mouse Hippocampus Lysate at 20 µgLane 4 : Rat Hippocampus Lysate at 20 µgSecondaryGoat polyclonal to Rabbit IgG (Alexa Fluor® 680) at 1/10000 dilutionPerformed under reducing conditions.

Anti-Insulin degrading enzyme / IDE antibody - ab63137 from Abcam

Prices $384.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-Insulin degrading enzyme / IDE antibody (ab63137) at 1/60 dilution + A375 cell line lysates at 35 µg

Anti-Insulin degrading enzyme / IDE antibody - ab185809 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human stomach cancer tissue labelling Insulin degrading enzyme / IDE with ab185809 at 1/200. Magnification: 400x.

Anti-Insulin degrading enzyme / IDE antibody - ab28561 from Abcam

Prices $378.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Insulin degrading enzyme / IDE antibody (ab28561) at 1/1000 dilutionLane 1 : Insulysin at 0.05 µgLane 2 : Insulysin at 0.01 µgLane 3 : Insulysin at 0.001 µg

Anti-Insulin degrading enzyme / IDE antibody - ab62829 from Abcam

Prices $376.00
Sizes 200 µl
Host Goat
Clonality Polyclonal
Anti-Insulin degrading enzyme / IDE antibody (ab62829) at 1 µg/ml + Mouse brain lysate at 35 µg

Anti-Insulin degrading enzyme / IDE antibody - ab63945 from Abcam

Prices $376.00
Sizes 200 µl
Host Goat
Clonality Polyclonal
Anti-Insulin degrading enzyme / IDE antibody (ab63945) at 0.1 µg/ml (1 hour) + K562 cell lysate in RIPA buffer at 35 µgdeveloped using the ECL technique

Anti-Insulin degrading enzyme / IDE antibody - ab28562 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Insulin degrading enzyme / IDE antibody (ab28562) at 1/1000 dilutionLane 1 : Insulysin at 0.05 µgLane 2 : Insulysin at 0.01 µgLane 3 : Insulysin at 0.001 µg

Anti-Insulin degrading enzyme / IDE antibody [9B12.225] - ab25733 from Abcam

Prices $384.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 9B12.225
Insulin Degrading Enzyme (9B12.225) antibody immnunostaining on a paraffin embedded section of human brain. Intense IDE staining is observed with ab25733 in hippocampal dentate granular layer, hilus and CA-2/3 with lower low levels in the CA1 region.

Anti-Insulin degrading enzyme / IDE antibody [EPR6098(2)] - ab133561 from Abcam

Prices $385.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR6098(2)
All lanes : Anti-Insulin degrading enzyme / IDE antibody [EPR6098(2)] (ab133561) at 1/1000 dilutionLane 1 : HeLa cell lysateLane 2 : HepG2 cell lysateLane 3 : A375 cell lysateLane 4 : K562 cell lysateLysates/proteins at 10 µg per lane.SecondaryHRP labelled goat anti-rabbit at 1/2000 dilution

Anti-Insulin degrading enzyme / IDE antibody [EPR6099] - ab109538 from Abcam

Prices $379.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR6099
All lanes : Anti-Insulin degrading enzyme / IDE antibody [EPR6099] (ab109538) at 1/10000 dilutionLane 1 : HeLa cell lysateLane 2 : HepG2 cell lysateLane 3 : A375 cell lysateLane 4 : K562 cell lysateLysates/proteins at 10 µg per lane.SecondaryHRP-labelled goat anti-rabbit at 1/2000 dilution

Anti-Insulin degrading enzyme / IDE antibody - Carboxyterminal end - ab39889 from Abcam

Prices $378.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Insulin degrading enzyme / IDE antibody - Carboxyterminal end (ab39889) at 1/1000 dilutionLane 1 : Insulysin at 0.05 µgLane 2 : Insulysin at 0.01 µgLane 3 : Insulysin at 0.001 µg

Anti-Insulin degrading enzyme / IDE antibody - Catalytic domain - ab28560 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Insulin degrading enzyme / IDE antibody - Catalytic domain (ab28560) at 1/1000 dilutionLane 1 : Insulysin at 0.05 µgLane 2 : Insulysin at 0.01 µgLane 3 : Insulysin at 0.001 µg

Anti-IDE Antibody (aa914-924) IHC-plus™ - LS-B3954 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
Anti-IDE antibody IHC of human lung. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B3954 concentration 2.5 ug/ml.

Anti-IDE Antibody (Internal, FITC) - LS-C278544 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-IDE Antibody (aa90-139) - LS-C145525 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
IDE antibody LS-C145525 Western blot of HeLa Cell lysate. Antibody concentration 1 ug/ml.

Anti-IDE Antibody (Internal, clone EPR6099) - LS-C138629 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR6099
Western blot analysis on (A) Hela, (B) HepG2, (C) A375, and (D) K562 cell lysates using anti-IDE antibody.

Anti-IDE Antibody (Internal, Azide-free, HRP) - LS-C278545 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-IDE Antibody (Internal, PE) - LS-C278547 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-IDE Antibody (Internal) - LS-C327665 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-IDE Antibody (Internal, clone EPR6098(2)) - LS-C138867 from LifeSpan Bioscience

Prices $485.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR6098(2)
IHC of paraffin-embedded human colon tissue using anti-IDE antibody.
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