IDE

Gene Symbol IDE
Entrez Gene 3416
Alt Symbol INSULYSIN
Species Human
Gene Type protein-coding
Description insulin-degrading enzyme
Other Description Abeta-degrading protease|insulin protease|insulinase
Swissprots Q5T5N2 P14735 B7ZAU2 B2R721 D3DR35
Accessions CBA13324 EAW50090 EAW50091 EAW50092 EAW50093 P14735 AB209204 BAD92441 AK093287 BAG52680 AK302578 BAH13752 AK312810 BAG35668 AK316407 BAH14778 BC036188 BC096336 AAH96336 BC096337 AAH96337 BC096338 BC096339 AAH96339 BX648462 CF780766 CK824565 DA643304 DA879845 DB204538 DB219527 DB445060 M21188 AAA52712 XM_005269766 XP_005269823 XM_005269769 XP_005269826 XR_945727 NM_001165946 NP_001159418 NM_004969 NP_004960
Function Plays a role in the cellular breakdown of insulin, IAPP, glucagon, bradykinin, kallidin and other peptides, and thereby plays a role in intercellular peptide signaling. Degrades amyloid formed by APP and IAPP. May play a role in the degradation and clearance of naturally secreted amyloid beta-protein by neurons and microglia. {ECO:0000269|PubMed:10684867, ECO:0000269|PubMed:17613531, ECO:0000269|PubMed:18986166}.
Subcellular Location Cytoplasm. Cell membrane. Secreted {ECO:0000250}. Note=Present at the cell surface of neuron cells. The membrane-associated isoform is approximately 5 kDa larger than the known cytosolic isoform.
Top Pathways Alzheimer's disease

Human Insulin degrading enzyme / IDE protein fragment - ab152467 from Abcam

Category Protein
Source Wheat germ
Species Human
12.5% SDS-PAGE analysis of ab152467 stained with Coomassie Blue.

IDE Antibody Blocking Peptide - LS-E10675 from LifeSpan Bioscience

Category Peptide
Prices $145.00
Sizes 100 µg

IDE Antibody Blocking Peptide - LS-E26391 from LifeSpan Bioscience

Category Peptide
Prices $145.00
Sizes 100 µg

IDE Antibody Blocking Peptide - LS-E26392 from LifeSpan Bioscience

Category Peptide
Prices $145.00
Sizes 100 µg

Insulysin/IDE Partial Recombinant Protein - H00003416-Q01 from Novus Biologicals

Category Protein
Prices $369.00
Sizes 10 µg
Species Human

Insulysin/IDE Recombinant Protein - H00003416-P01 from Novus Biologicals

Category Protein
Prices $319.00
Sizes 2 µg
Species Human

IDE blocking peptide - GTX89007-PEP from GeneTex

Category Peptide
Prices $239.00
Sizes 100 μg
Species Human, Dog

Recombinant Human Insulysin/IDE, CF - 2496-ZN-010 from R&D Systems

Category Protein
Source Spodoptera frugiperda, Sf 21 (baculovirus)-derived, Met42-Leu1019, with an N-terminal Met and 7-His tag

IDE Blocking Peptide - 33R-10357 from Fitzgerald

Category Peptide
Prices $130.00
Sizes 100 µg

Human IDE Protein - abx067222 from Abbexa

Category Protein
Source E.coli
Species Human

Insulin Degrading Enzyme / Ide Peptide - AC21-1227-P from Abcore

Category Peptide
Prices $160.00
Sizes 100 µg

Insulin-degrading enzyme - H00003416-P01-10 from Acris Antibodies

Category Protein
Prices $370.00
Sizes 10 µg
Species Human

Insulin-degrading enzyme - H00003416-P01-25 from Acris Antibodies

Category Protein
Prices $520.00
Sizes 25 µg
Species Human

Insulin-degrading enzyme - H00003416-Q01-10 from Acris Antibodies

Category Protein
Prices $380.00
Sizes 10 µg
Source in vitro transl.
Species Human

Insulin-degrading enzyme - H00003416-Q01-25 from Acris Antibodies

Category Protein
Prices $500.00
Sizes 25 µg
Source in vitro transl.
Species Human

Insulysin Peptide - 45-776P from ProSci

Category Peptide
Prices $175.00
Sizes 100 µg
Species Human

IDE fusion protein - ag16392 from Proteintech Group

Category Protein
Source E. coli-derived, PGEX-4T
Species Human

IDE fusion protein - Ag17161 from Proteintech Group

Category Protein
Prices $199.00
Sizes 50 μg
Source E. coli -derived, PET28a
Species Human

Recombinant Human Insulin-degrading enzyme - BP001392-CA05 from Syd Labs

Category Protein
Prices $180.00, $528.00, $2,640.00
Sizes 10 µg, 50 µg, 1 mg
Source HEK 293-derived.
Species Human

Recombinant Human Insulin-degrading Enzyme, His-tagged - IDE-255H from Creative Biomart

Category Protein
Source Escherichia Coli .
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