| Gene Symbol |
IDE
|
| Entrez Gene |
3416
|
| Alt Symbol |
INSULYSIN
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
insulin-degrading enzyme
|
| Other Description |
Abeta-degrading protease|insulin protease|insulinase
|
| Swissprots |
Q5T5N2 P14735 B7ZAU2 B2R721 D3DR35
|
| Accessions |
CBA13324 EAW50090 EAW50091 EAW50092 EAW50093 P14735 AB209204 BAD92441 AK093287 BAG52680 AK302578 BAH13752 AK312810 BAG35668 AK316407 BAH14778 BC036188 BC096336 AAH96336 BC096337 AAH96337 BC096338 BC096339 AAH96339 BX648462 CF780766 CK824565 DA643304 DA879845 DB204538 DB219527 DB445060 M21188 AAA52712 XM_005269766 XP_005269823 XM_005269769 XP_005269826 XR_945727 NM_001165946 NP_001159418 NM_004969 NP_004960
|
| Function |
Plays a role in the cellular breakdown of insulin, IAPP, glucagon, bradykinin, kallidin and other peptides, and thereby plays a role in intercellular peptide signaling. Degrades amyloid formed by APP and IAPP. May play a role in the degradation and clearance of naturally secreted amyloid beta-protein by neurons and microglia. {ECO:0000269|PubMed:10684867, ECO:0000269|PubMed:17613531, ECO:0000269|PubMed:18986166}.
|
| Subcellular Location |
Cytoplasm. Cell membrane. Secreted {ECO:0000250}. Note=Present at the cell surface of neuron cells. The membrane-associated isoform is approximately 5 kDa larger than the known cytosolic isoform.
|
| Top Pathways |
Alzheimer's disease
|