SFPQ

Gene Symbol SFPQ
Entrez Gene 6421
Alt Symbol POMP100, PPP1R140, PSF
Species Human
Gene Type protein-coding
Description splicing factor proline/glutamine-rich
Other Description 100 kDa DNA-pairing protein|DNA-binding p52/p100 complex, 100 kDa subunit|PTB-associated splicing factor|PTB-associated-splicing factor|hPOMp100|polypyrimidine tract binding protein associated|polypyrimidine tract-binding protein-associated splicing factor|polypyrimidine tract-binding protein-associated-splicing factor|protein phosphatase 1, regulatory subunit 140|splicing factor proline/glutamine rich (polypyrimidine tract binding protein associated)|splicing factor proline/glutamine rich (polypyrimidine tract-binding protein-associated)|splicing factor, proline- and glutamine-rich
Swissprots Q5SZ71 P30808 P23246
Accessions EAX07421 EAX07422 EAX07423 EAX07424 EAX07425 EAX07426 P23246 AK095702 AK307985 AL831889 AL833670 BC000546 BC004534 AAH04534 BC027708 AAH27708 BC027717 BC051192 AAH51192 BX537811 X16850 CAA34747 X70944 CAA50283 XM_005271112 XP_005271169 XM_005271113 XP_005271170 XM_005271115 XP_005271172 XM_011541950 XP_011540252 NM_005066 NP_005057
Function DNA- and RNA binding protein, involved in several nuclear processes. Essential pre-mRNA splicing factor required early in spliceosome formation and for splicing catalytic step II, probably as a heteromer with NONO. Binds to pre-mRNA in spliceosome C complex, and specifically binds to intronic polypyrimidine tracts. Involved in regulation of signal-induced alternative splicing. During splicing of PTPRC/CD45, a phosphorylated form is sequestered by THRAP3 from the pre-mRNA in resting T-cells; T-cell activation and subsequent reduced phosphorylation is proposed to lead to release from THRAP3 allowing binding to pre-mRNA splicing regulatotry elements which represses exon inclusion. Interacts with U5 snRNA, probably by binding to a purine-rich sequence located on the 3' side of U5 snRNA stem 1b. May be involved in a pre-mRNA coupled splicing and polyadenylation process as component of a snRNP-free complex with SNRPA/U1A. The SFPQ-NONO heteromer associated with MATR3 may play a role in nucle
Subcellular Location Nucleus matrix. Cytoplasm. Note=Predominantly in nuclear matrix.

PSF (G-7) - sc-374502 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
PSF (G-7): sc-374502. Western blot analysis of PSF expression in A-431 nuclear extract.

PSF (K-18) - sc-30818 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
PSF (K-18): sc-30818. Western blot analysis of PSF expression in HeLa (A) and A-431 (B) nuclear extracts.

PSF (D-8) - sc-271796 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
PSF (D-8): sc-271796. Western blot analysis of PSF expression in Hep G2 (A) and A-431 (B) nuclear extracts.

PSF (A-20) - sc-18373 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

PSF (H-80) - sc-28730 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
PSF (H-80): sc-28730. Immunoperoxidase staining of formalin fixed, paraffin-embedded human cerebral cortex tissue showing nuclear staining of neuronal and non-neuronal cells at low (A) and high (B) magnification. Kindly provided by The Swedish Human Protein Atlas (HPA) program.

PSF (39-1) - sc-101137 from Santa Cruz Biotechnology

Prices $295.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
PSF (39-1): sc-101137. Immunoperoxidase staining of formalin-fixed, paraffin-embedded human thyroid nodular goiter tissue showing nuclear localization.

Anti-SFPQ antibody - ab38148 from Abcam

Prices $390.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-SFPQ antibody (ab38148) at 1 µg/mlLane 1 : HeLa (Human epithelial carcinoma cell line) Whole Cell Lysate Lane 2 : HEK293 (Human embryonic kidney cell line) Whole Cell LysateLane 3 : MCF7 (Human breast adenocarcinoma cell line) Whole Cell LysateLane 4 : HepG2 (Human hepatocellular liver carcinoma cell line) Whole Cell LysateLysates/proteins at 10 µg per lane.SecondaryIRDye 680 Conjugated Goat Anti-Rabbit IgG (H+L) at 1/10000 dilutionPerformed under reducing conditions.

Anti-SFPQ antibody - ab99357 from Abcam

Prices $384.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human prostate carcinoma (left) and mouse CT26 colon carcinoma (right) tissues labelling SFPQ with ab99357 at 1/500 (0.4 µg/ml). Detection: DAB.

Anti-SFPQ antibody - ab76955 from Abcam

Prices $384.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Anti-SFPQ antibody (ab76955) at 1 µg/ml + Recombinant tagged human SFPQ fragment at 0.2 µgSecondaryGoat anti-Mouse IgG (H&L)-HRP at 1/5000 dilution

Anti-SFPQ antibody - ab50935 from Abcam

Prices $384.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human heart tissue labelling SFPQ with ab50935 at 4.0-8.0µg/ml. Positive staining shown in cardiac cells. Magnification: 400X.

Anti-SFPQ antibody - ab56050 from Abcam

Prices $384.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-SFPQ antibody (ab56050) at 5 µg/ml + Jurkat cell lysate at 10 µgSecondaryHRP conjugated anti-Rabbit IgG at 1/50000 dilution

Anti-SFPQ antibody - ab118486 from Abcam

Prices $376.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
ab118486 at 7.5&microg/ml staining SFPQ in Formalin-fixed, Paraffin-embedded Human kidney tissue by immunohistochemistry.

Anti-SFPQ antibody [6D7] - ab117617 from Abcam

Prices $384.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 6D7
Anti-SFPQ antibody [6D7] (ab117617) at 1/500 dilution + HeLa nuclear extract

Anti-SFPQ antibody [B92] - ab11825 from Abcam

Prices $378.00
Sizes 50 µl
Host Mouse
Clonality Monoclonal
Clone B92

Anti-SFPQ antibody [EPR11846] - ab177936 from Abcam

Prices $385.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR11846
All lanes : Anti-SFPQ antibody [EPR11846] (ab177936) at 1/1000 dilutionLane 1 : Jurkat cell lysateLane 2 : 293T cell lysateLane 3 : HeLa cell lysateLane 4 : C6 cell lysateLysates/proteins at 10 µg per lane.

Anti-SFPQ antibody [EPR11847] - ab177149 from Abcam

Prices $387.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR11847
All lanes : Anti-SFPQ antibody [EPR11847] (ab177149) at 1/10000 dilutionLane 1 : Neuro-2a cell lysateLane 2 : NIH 3T3 cell lysateLane 3 : Raw264.7 cell lysateLane 4 : 293T cell lysateLane 5 : A431 cell lysateLane 6 : HeLa cell lysateLane 7 : Jurkat cell lysateLysates/proteins at 10 µg per lane.SecondaryGoat anti-rabbit HRP at 1/2000 dilution

Anti-SFPQ Antibody (clone 6D7) IHC-plus™ - LS-B5530 from LifeSpan Bioscience

Prices $450.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 6D7
Anti-SFPQ antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B5530 concentration 5 ug/ml.

Anti-SFPQ Antibody (aa657-707) IHC-plus™ - LS-B12214 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Human Skin: Formalin-Fixed, Paraffin-Embedded (FFPE)

Anti-SFPQ Antibody (aa657-707) - LS-C286544 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
Detection of Human PSF/SFPQ by Immunohistochemistry. Sample: FFPE section of human colon carcinoma. Antibody: Affinity purified rabbit anti-PSF/SFPQ used at a dilution of 1:250.

Anti-SFPQ Antibody - LS-C91362 from LifeSpan Bioscience

Prices $485.00
Sizes 50 µl
Host Mouse
Clonality Monoclonal

Anti-SFPQ Antibody (aa269-362, clone 10B2482, Azide-free) - LS-C183717 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal
Clone 10B2482

Anti-SFPQ Antibody (aa676-705, AP) - LS-C269113 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SFPQ Antibody (aa676-705, APC) - LS-C269114 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SFPQ Antibody (aa676-705, Biotin) - LS-C269117 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SFPQ Antibody (aa676-705, FITC) - LS-C269118 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
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