TNFRSF21

Gene Symbol TNFRSF21
Entrez Gene 27242
Alt Symbol BM-018, CD358, DR6
Species Human
Gene Type protein-coding
Description tumor necrosis factor receptor superfamily, member 21
Other Description TNFR-related death receptor 6|death receptor 6|tumor necrosis factor receptor superfamily member 21
Swissprots O75509 Q96D86 Q0D2P5 B2RDI9
Accessions CBX47587 EAX04314 EAX04315 EAX04316 EAX04317 EAX04318 O75509 AB209394 BAD92631 AF068868 AAC34583 AF208860 AAF64274 AJ420531 AK001504 BAG50928 AK025399 AK315560 BAG37936 AY358304 AAQ88671 BC005192 BC010241 AAH10241 BC015466 BC017730 AAH17730 BC021572 AAH21572 BI561782 BT007420 AAP36088 CR457190 CAG33471 DQ890769 ABM81695 DQ893930 ABM84856 DR761236 HY007775 XM_011514495 XP_011512797 NM_014452 NP_055267
Function Promotes apoptosis, possibly via a pathway that involves the activation of NF-kappa-B. Can also promote apoptosis mediated by BAX and by the release of cytochrome c from the mitochondria into the cytoplasm. Plays a role in neuronal apoptosis, including apoptosis in response to amyloid peptides derived from APP, and is required for both normal cell body death and axonal pruning. Trophic-factor deprivation triggers the cleavage of surface APP by beta-secretase to release sAPP-beta which is further cleaved to release an N-terminal fragment of APP (N-APP). N-APP binds TNFRSF21; this triggers caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase- 6). Negatively regulates oligodendrocyte survival, maturation and myelination. Plays a role in signaling cascades triggered by stimulation of T-cell receptors, in the adaptive immune response and in the regulation of T-cell differentiation and proliferation. Negatively regulates T-cell responses and
Subcellular Location Cell membrane {ECO:0000269|PubMed:19654028}; Single-pass type I membrane protein {ECO:0000269|PubMed:19654028}.
Tissue Specificity Detected in fetal spinal cord and in brain neurons, with higher levels in brain from Alzheimer disease patients (at protein level). Highly expressed in heart, brain, placenta, pancreas, lymph node, thymus and prostate. Detected at lower levels in lung, skeletal muscle, kidney, testis, uterus, small intestine, colon, spleen, bone marrow and fetal liver. Very low levels were found in adult liver and peripheral blood leukocytes. {ECO:0000269|PubMed:21725297, ECO:0000269|PubMed:23559013, ECO:0000269|PubMed:9714541}.
Top Pathways Cytokine-cytokine receptor interaction

Phospho-DR6 (Ser562) Antibody - 7616 from Cell Signaling Technology

Prices $287.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from serum-starved A-431 cells, untreated (-) or treated with Human Epidermal Growth Factor (hEGF) #8916 (100 ng/ml, 30 min) (+) using Phospho-DR6 (Ser562) Antibody (top) or α-Tubulin (11H10) Rabbit mAb #2125 (bottom).

DR6 (E-4) - sc-376873 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
DR6 (E-4): sc-376873. Western blot analysis of DR6 expression in non-transfected: sc-117752 (A) and human DR6 transfected: sc-173778 (B) 293T whole cell lysates.

DR6 (E-17) - sc-5866 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
DR6 (E-17): sc-5866. Western blot analysis of DR6 expression in CCRF-CEM (A) and Jurkat (B) whole cell lysates.

DR6 (H-150) - sc-25772 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
DR6 (H-150): sc-25772. Western blot analysis of DR6 expression in Jurkat whole cell lysate.

DR6 (H-300) - sc-13106 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
DR6 (H-300): sc-13106. Immunoperoxidase staining of formalin fixed, paraffin-embedded human cerebellum tissue showing cytoplasmic staining of Perkinje cells and cells in granular and molecular layers.

Anti-DR6 antibody - ab198034 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of paraffin-embedded Human brain tissue labeling DR6 with ab198034 at 1/20 dilution.

Anti-DR6 antibody - ab8417 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-DR6 antibody (ab8417) at 1/500 dilutionLane 1 : K562 whole cell lysate with absence of blocking peptideLane 2 : Raji whole cell lysate with absence of blocking peptideLane 3 : K562 whole cell lysate with Human DR6 peptide (ab8450)Lane 4 : Raji whole cell lysate with Human DR6 peptide (ab8450)Observed band size : 68 kDa (why is the actual band size different from the predicted?)

Anti-DR6 antibody - ab89770 from Abcam

Host Mouse
Clonality Polyclonal
Anti-DR6 antibody (ab89770) at 1 µg/ml + human colon tissue lysate at 50 µg

Anti-DR6 antibody - ab130714 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-DR6 antibody (ab130714) at 1/100 dilution + A549 cell line lysates at 35 µgdeveloped using the ECL technique

Anti-DR6 antibody - ab11933 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-DR6 antibody - ab47180 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-DR6 antibody (ab47180) at 2 µg/mlLane 1 : Total cell lysate from Jurkat cellsLane 2 : Total cell lysate from HeLa cellsLane 3 : Total cell lysate from Daudi cellsLysates/proteins at 30 µg per lane.

Anti-DR6 antibody [DR-6-04-EC] - ab14740 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone DR-6-04-EC
ab14740 staining DR6 (green) in transiently transfected human Hela cells by ICC/IF. Nuclei were stained with DAPI (blue).

Anti-DR6 antibody [DR-6-04-EC] (FITC) - ab187579 from Abcam

Prices $216.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone DR-6-04-EC

Anti-DR6 antibody [DR-6-04-EC] (Phycoerythrin) - ab52513 from Abcam

Prices $216.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone DR-6-04-EC

Anti-DR6 antibody [Luke-1] - ab17318 from Abcam

Prices $370.00
Sizes 50 µg
Host Rat
Clonality Monoclonal
Clone Luke-1
Ab17318 at a concentration of 1 ug/ml used in mock transfecting (thin line) or transfecting (thick line) HEK 293T cells with an expression plasmid coding for the extracellular domain of human DR6 by Flow Cytometry.

Anti-HLA-DR3/DR6 Antibody - LS-C24562 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal

Anti-HLA-DR3/DR6 Antibody - LS-C24563 from LifeSpan Bioscience

Prices $405.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal

Anti-TNFRSF21 / DR6 Antibody (aa42-335) - LS-C14936 from LifeSpan Bioscience

Prices $465.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-TNFRSF21 / DR6 Antibody (aa372-665) - LS-C14935 from LifeSpan Bioscience

Prices $445.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-TNFRSF21 / DR6 Antibody (aa42-56) - LS-C14933 from LifeSpan Bioscience

Prices $415.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-TNFRSF21 / DR6 Antibody - LS-C18660 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µg
Host Rat
Clonality Monoclonal

Anti-TNFRSF21 / DR6 Antibody (aa42-335, clone DR-6-04-EC) - LS-C46073 from LifeSpan Bioscience

Prices $290.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone DR-6-04-EC

Anti-TNFRSF21 / DR6 Antibody (aa42-335) - LS-C44700 from LifeSpan Bioscience

Prices $375.00
Sizes 200 µg
Host Mouse
Clonality Monoclonal

Anti-TNFRSF21 / DR6 Antibody (aa42-335, clone Luke-1) - LS-C53520 from LifeSpan Bioscience

Prices $445.00
Sizes 50 µg
Host Rat
Clonality Monoclonal
Clone Luke-1

Anti-TNFRSF21 / DR6 Antibody (aa42-335, clone DR-6-04-EC, PE) - LS-C46512 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone DR-6-04-EC
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