TNFRSF21

Gene Symbol	TNFRSF21
Entrez Gene	27242
Alt Symbol	BM-018, CD358, DR6
Species	Human
Gene Type	protein-coding
Description	tumor necrosis factor receptor superfamily, member 21
Other Description	TNFR-related death receptor 6|death receptor 6|tumor necrosis factor receptor superfamily member 21
Swissprots	O75509 Q96D86 Q0D2P5 B2RDI9
Accessions	CBX47587 EAX04314 EAX04315 EAX04316 EAX04317 EAX04318 O75509 AB209394 BAD92631 AF068868 AAC34583 AF208860 AAF64274 AJ420531 AK001504 BAG50928 AK025399 AK315560 BAG37936 AY358304 AAQ88671 BC005192 BC010241 AAH10241 BC015466 BC017730 AAH17730 BC021572 AAH21572 BI561782 BT007420 AAP36088 CR457190 CAG33471 DQ890769 ABM81695 DQ893930 ABM84856 DR761236 HY007775 XM_011514495 XP_011512797 NM_014452 NP_055267
Function	Promotes apoptosis, possibly via a pathway that involves the activation of NF-kappa-B. Can also promote apoptosis mediated by BAX and by the release of cytochrome c from the mitochondria into the cytoplasm. Plays a role in neuronal apoptosis, including apoptosis in response to amyloid peptides derived from APP, and is required for both normal cell body death and axonal pruning. Trophic-factor deprivation triggers the cleavage of surface APP by beta-secretase to release sAPP-beta which is further cleaved to release an N-terminal fragment of APP (N-APP). N-APP binds TNFRSF21; this triggers caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase- 6). Negatively regulates oligodendrocyte survival, maturation and myelination. Plays a role in signaling cascades triggered by stimulation of T-cell receptors, in the adaptive immune response and in the regulation of T-cell differentiation and proliferation. Negatively regulates T-cell responses and
Subcellular Location	Cell membrane {ECO:0000269|PubMed:19654028}; Single-pass type I membrane protein {ECO:0000269|PubMed:19654028}.
Tissue Specificity	Detected in fetal spinal cord and in brain neurons, with higher levels in brain from Alzheimer disease patients (at protein level). Highly expressed in heart, brain, placenta, pancreas, lymph node, thymus and prostate. Detected at lower levels in lung, skeletal muscle, kidney, testis, uterus, small intestine, colon, spleen, bone marrow and fetal liver. Very low levels were found in adult liver and peripheral blood leukocytes. {ECO:0000269|PubMed:21725297, ECO:0000269|PubMed:23559013, ECO:0000269|PubMed:9714541}.
Top Pathways	Cytokine-cytokine receptor interaction

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human-TNFRSF21-cDNA-Clone - DC02890 from Abgent, a WuXi AppTec company Prices $637.20 Sizes 10 µg Species Human Accession BC010241

TNFRSF21 - MBS1265973 from MyBioSource Prices $175.00 Sizes 10ug plasmid + 200ul glycerol stock Species Human Accession BC010241

TNFRSF21 - MBS1268175 from MyBioSource Prices $175.00 Sizes 10ug plasmid + 200ul glycerol stock Species Human Accession BC017730

TNFRSF21 - MBS1273565 from MyBioSource Prices $175.00 Sizes 10ug plasmid + 200ul glycerol stock Species Human Accession BC005192

Human TNFRSF21 cDNA clone(NM_014452.3) - CDFH020009 from Creative Biomart Species Human Accession NM_014452.3

Human TNFRSF21 ORF Clone(NM_014452.3) - CDCR297442 from Creative Biomart Species Human Accession NM_014452.3

Human TNFRSF21 ORF Clone(NM_014452.3) - CDCR297443 from Creative Biomart Species Human Accession NM_014452.3

Human TNFRSF21 ORF Clone(NM_014452.3) - CDCR297444 from Creative Biomart Species Human Accession NM_014452.3

human TNFRSF21 ORF clone - CDCH093532 from Creative Biomart Species Human Accession NM_014452

human TNFRSF21 ORF clone - CDCH093533 from Creative Biomart Species Human Accession NM_014452

human TNFRSF21 ORF clone - CDCH093534 from Creative Biomart Species Human Accession NM_014452

human TNFRSF21 ORF clone - CDCH093535 from Creative Biomart Species Human Accession NM_014452

human TNFRSF21 ORF clone - CDCH093536 from Creative Biomart Species Human Accession NM_014452

human TNFRSF21 ORF clone - CDCH093537 from Creative Biomart Species Human Accession NM_014452

Human TNFRSF21 ORF Clone(NM_014452.3) - CDCL179227 from Creative Biomart Species Human Accession NM_014452.3

Human TNFRSF21 ORF Clone(NM_014452.3) - CDCL179229 from Creative Biomart Species Human Accession NM_014452.3

Human TNFRSF21/DR6 Gene ORF cDNA clone in cloning vector - HG10175-M from Sino Biological Species Human

Human TNFRSF21/DR6 Gene ORF cDNA clone in cloning vector - HG12171-G from Sino Biological Species Human

Human TNFRSF21/DR6 Gene ORF cDNA clone expression plasmid, C-His tag - HG10175-CH from Sino Biological Species Human

Human TNFRSF21/DR6 Gene ORF cDNA clone expression plasmid, N-Flag tag - HG10175-NF from Sino Biological Species Human

Human TNFRSF21/DR6 Gene ORF cDNA clone expression plasmid, C-Flag tag - HG10175-CF from Sino Biological Species Human

Human TNFRSF21/DR6 Gene ORF cDNA clone expression plasmid, N-Myc tag - HG10175-NM from Sino Biological Species Human

Human TNFRSF21/DR6 Gene ORF cDNA clone expression plasmid, N-HA tag - HG10175-NY from Sino Biological Species Human

Human TNFRSF21/DR6 Gene ORF cDNA clone expression plasmid - HG12171-UT from Sino Biological Species Human

Human TNFRSF21/DR6 Gene ORF cDNA clone expression plasmid, N-HA tag - HG12171-NY from Sino Biological Species Human

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