TNFRSF21

Gene Symbol	TNFRSF21
Entrez Gene	27242
Alt Symbol	BM-018, CD358, DR6
Species	Human
Gene Type	protein-coding
Description	tumor necrosis factor receptor superfamily, member 21
Other Description	TNFR-related death receptor 6|death receptor 6|tumor necrosis factor receptor superfamily member 21
Swissprots	O75509 Q96D86 Q0D2P5 B2RDI9
Accessions	CBX47587 EAX04314 EAX04315 EAX04316 EAX04317 EAX04318 O75509 AB209394 BAD92631 AF068868 AAC34583 AF208860 AAF64274 AJ420531 AK001504 BAG50928 AK025399 AK315560 BAG37936 AY358304 AAQ88671 BC005192 BC010241 AAH10241 BC015466 BC017730 AAH17730 BC021572 AAH21572 BI561782 BT007420 AAP36088 CR457190 CAG33471 DQ890769 ABM81695 DQ893930 ABM84856 DR761236 HY007775 XM_011514495 XP_011512797 NM_014452 NP_055267
Function	Promotes apoptosis, possibly via a pathway that involves the activation of NF-kappa-B. Can also promote apoptosis mediated by BAX and by the release of cytochrome c from the mitochondria into the cytoplasm. Plays a role in neuronal apoptosis, including apoptosis in response to amyloid peptides derived from APP, and is required for both normal cell body death and axonal pruning. Trophic-factor deprivation triggers the cleavage of surface APP by beta-secretase to release sAPP-beta which is further cleaved to release an N-terminal fragment of APP (N-APP). N-APP binds TNFRSF21; this triggers caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase- 6). Negatively regulates oligodendrocyte survival, maturation and myelination. Plays a role in signaling cascades triggered by stimulation of T-cell receptors, in the adaptive immune response and in the regulation of T-cell differentiation and proliferation. Negatively regulates T-cell responses and
Subcellular Location	Cell membrane {ECO:0000269|PubMed:19654028}; Single-pass type I membrane protein {ECO:0000269|PubMed:19654028}.
Tissue Specificity	Detected in fetal spinal cord and in brain neurons, with higher levels in brain from Alzheimer disease patients (at protein level). Highly expressed in heart, brain, placenta, pancreas, lymph node, thymus and prostate. Detected at lower levels in lung, skeletal muscle, kidney, testis, uterus, small intestine, colon, spleen, bone marrow and fetal liver. Very low levels were found in adult liver and peripheral blood leukocytes. {ECO:0000269|PubMed:21725297, ECO:0000269|PubMed:23559013, ECO:0000269|PubMed:9714541}.
Top Pathways	Cytokine-cytokine receptor interaction

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human DR6 full length protein - ab131773 from Abcam Category Protein Source Wheat germ Species Human

Human DR6 full length protein - ab131774 from Abcam Category Protein Source Wheat germ Species Human

Human DR6 peptide - ab8450 from Abcam Category Peptide Species Human

Human DR6 protein fragment - ab56520 from Abcam Category Protein Source HEK 293 cells Species Human

Human DR6 protein fragment - ab151363 from Abcam Category Protein Source HEK 293 cells Species Human

Mouse DR6 protein fragment - ab186975 from Abcam Category Protein Source Mammalian Species Mouse

Mouse DR6 protein fragment - ab109063 from Abcam Category Protein Source HEK 293 cells Species Mouse

TNFRSF21 / DR6 Antibody Blocking Peptide - LS-E4908 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

TNFRSF21 / DR6 Antibody Blocking Peptide - LS-E17078 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

TNFRSF21 / DR6 Antibody Blocking Peptide - LS-E29906 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

Recombinant Human DR6/TNFRSF21 Protein - H00027242-P02 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

DR6/TNFRSF21 Recombinant Protein - H00027242-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

DR6/TNFRSF21 Blocking Peptide - NBP1-76463PEP from Novus Biologicals Category Peptide Prices $129.00 Sizes 50 µg Species Human

Recombinant Human DR6/TNFRSF21 Protein - H00027242-G01 from Novus Biologicals Category Protein Prices $569.00 Sizes 10 µg Source Wheat Germ Species Human

DR6/TNFRSF21 Recombinant Protein - P5033 from Novus Biologicals Category Protein Prices $799.00 Sizes 50 µg Species Human

TNFRSF21-Antibody-Center-Blocking-Peptide - BP17293c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

DR6 Cytoplasmic Domain Recombinant Protein - GTX48020-PRO from GeneTex Category Protein Prices $299.00 Sizes 50 μg Source E. coli Species Human

DR6 Extracellular Domain Recombinant Protein - GTX48019-PRO from GeneTex Category Protein Prices $299.00 Sizes 50 μg Source E. coli Species Human

DR6 peptide - GTX28450 from GeneTex Category Peptide Prices $179.00 Sizes 50 μg Species Human

Recombinant Human DR6/TNFRSF21 Fc Chimera, CF - 144-DR-100 from R&D Systems Category Protein Source Spodoptera frugiperda, Sf 21 (baculovirus)-derived

Human DR6 protein - orb49698 from Biorbyt Category Protein Prices $196.00, $349.00, $995.00, $1,386.00 Sizes 10 μg, 50 μg, 500 μg, 1 mg Source HEK293

Human TNFRSF 21 protein - orb83572 from Biorbyt Category Protein Prices $434.00, $612.00 Sizes 100 μg, 200 μg Source Human Species Human

Human TNFRSF21 (Fc) protein - orb180444 from Biorbyt Category Protein Prices $238.00, $315.00, $1,904.00, $2,695.00 Sizes 10 μg, 50 μg, 500 μg, 1 mg Source HEK293 Species Human

Human TNFRSF 21 protein - orb82976 from Biorbyt Category Protein Prices $400.00, $612.00 Sizes 100 μg, 200 μg Source Human Species Human

DR6 Blocking Peptide - 33R-10668 from Fitzgerald Category Peptide Prices $145.00 Sizes 50 µg

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