TNFRSF21

Gene Symbol	TNFRSF21
Entrez Gene	27242
Alt Symbol	BM-018, CD358, DR6
Species	Human
Gene Type	protein-coding
Description	tumor necrosis factor receptor superfamily, member 21
Other Description	TNFR-related death receptor 6|death receptor 6|tumor necrosis factor receptor superfamily member 21
Swissprots	O75509 Q96D86 Q0D2P5 B2RDI9
Accessions	CBX47587 EAX04314 EAX04315 EAX04316 EAX04317 EAX04318 O75509 AB209394 BAD92631 AF068868 AAC34583 AF208860 AAF64274 AJ420531 AK001504 BAG50928 AK025399 AK315560 BAG37936 AY358304 AAQ88671 BC005192 BC010241 AAH10241 BC015466 BC017730 AAH17730 BC021572 AAH21572 BI561782 BT007420 AAP36088 CR457190 CAG33471 DQ890769 ABM81695 DQ893930 ABM84856 DR761236 HY007775 XM_011514495 XP_011512797 NM_014452 NP_055267
Function	Promotes apoptosis, possibly via a pathway that involves the activation of NF-kappa-B. Can also promote apoptosis mediated by BAX and by the release of cytochrome c from the mitochondria into the cytoplasm. Plays a role in neuronal apoptosis, including apoptosis in response to amyloid peptides derived from APP, and is required for both normal cell body death and axonal pruning. Trophic-factor deprivation triggers the cleavage of surface APP by beta-secretase to release sAPP-beta which is further cleaved to release an N-terminal fragment of APP (N-APP). N-APP binds TNFRSF21; this triggers caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase- 6). Negatively regulates oligodendrocyte survival, maturation and myelination. Plays a role in signaling cascades triggered by stimulation of T-cell receptors, in the adaptive immune response and in the regulation of T-cell differentiation and proliferation. Negatively regulates T-cell responses and
Subcellular Location	Cell membrane {ECO:0000269|PubMed:19654028}; Single-pass type I membrane protein {ECO:0000269|PubMed:19654028}.
Tissue Specificity	Detected in fetal spinal cord and in brain neurons, with higher levels in brain from Alzheimer disease patients (at protein level). Highly expressed in heart, brain, placenta, pancreas, lymph node, thymus and prostate. Detected at lower levels in lung, skeletal muscle, kidney, testis, uterus, small intestine, colon, spleen, bone marrow and fetal liver. Very low levels were found in adult liver and peripheral blood leukocytes. {ECO:0000269|PubMed:21725297, ECO:0000269|PubMed:23559013, ECO:0000269|PubMed:9714541}.
Top Pathways	Cytokine-cytokine receptor interaction

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

TNFRSF21-Over-expression-Lysate - LY13431a from Abgent, a WuXi AppTec company Category Cell Lysate Prices $325.00 Sizes 100 µg

TNFRSF21 293T Cell Transient Overexpression Lysate(Denatured) - H00027242-T02 from Acris Antibodies Category Cell Lysate Prices $320.00 Sizes 100 µl

TNFRSF21 293 Cell Lysate - 402053 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg Disease Tumor

DR6/TNFRSF21 Overexpression Lysate (Native) - NBL1-17156 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

DR6 (h4): 293T Lysate - sc-112295 from Santa Cruz Biotechnology Category Cell Lysate Prices $205.00 Sizes 100 µg/200 µl Species Human

TNFRSF21 Over-expression Lysate Product - GWB-F09DF9 from Genway Biotech Category Cell Lysate Prices $346.00 Sizes 100 µg Species Human

Cynomolgus TNFRSF21 / DR6 HEK293 Cell Lysate (WB positive control) - 90331-C08HL-300 from Sino Biological Category Cell Lysate Prices $195.00 Sizes 300 µg Species Cynomolgus

Human DR6 / TNFRSF21 HEK293 Cell Lysate (WB positive control) - 10175-HCCHL-300 from Sino Biological Category Cell Lysate Prices $195.00 Sizes 300 µg Species Human

Human DR6 / TNFRSF21 HEK293 Cell Lysate (WB positive control) - 10175-H08HL-300 from Sino Biological Category Cell Lysate Prices $195.00 Sizes 300 µg Species Human

Human DR6 / TNFRSF21 HEK293 Cell Lysate (WB positive control) - 10175-H02HL-300 from Sino Biological Category Cell Lysate Prices $195.00 Sizes 300 µg Species Human

DR6/TNFRSF21 Overexpression Lysate (Denatured) - H00027242-T02 from Novus Biologicals Category Cell Lysate Prices $279.00 Sizes 100 µl

DR6/TNFRSF21 Overexpression Lysate (Denatured) - H00027242-T03 from Novus Biologicals Category Cell Lysate Prices $299.00 Sizes 100 µl

Human DR6 Human Cells Transfected Lysate (positive control) (denatured) - orb173334 from Biorbyt Category Cell Lysate Prices $604.00 Sizes 300 μg Species Human

Human DR6 Human Cells Transfected Lysate (positive control) (denatured) - orb172880 from Biorbyt Category Cell Lysate Prices $604.00 Sizes 300 μg Species Human

Human DR6 Human Cells Transfected Lysate (positive control) (denatured) - orb172879 from Biorbyt Category Cell Lysate Prices $604.00 Sizes 300 μg Species Human

Panoply™ Human TNFRSF21 Knockdown Stable Cell Line - CSC-DC016365 from Creative biogene Category Cell Line Species Human

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