TNFRSF21

Gene Symbol TNFRSF21
Entrez Gene 27242
Alt Symbol BM-018, CD358, DR6
Species Human
Gene Type protein-coding
Description tumor necrosis factor receptor superfamily, member 21
Other Description TNFR-related death receptor 6|death receptor 6|tumor necrosis factor receptor superfamily member 21
Swissprots O75509 Q96D86 Q0D2P5 B2RDI9
Accessions CBX47587 EAX04314 EAX04315 EAX04316 EAX04317 EAX04318 O75509 AB209394 BAD92631 AF068868 AAC34583 AF208860 AAF64274 AJ420531 AK001504 BAG50928 AK025399 AK315560 BAG37936 AY358304 AAQ88671 BC005192 BC010241 AAH10241 BC015466 BC017730 AAH17730 BC021572 AAH21572 BI561782 BT007420 AAP36088 CR457190 CAG33471 DQ890769 ABM81695 DQ893930 ABM84856 DR761236 HY007775 XM_011514495 XP_011512797 NM_014452 NP_055267
Function Promotes apoptosis, possibly via a pathway that involves the activation of NF-kappa-B. Can also promote apoptosis mediated by BAX and by the release of cytochrome c from the mitochondria into the cytoplasm. Plays a role in neuronal apoptosis, including apoptosis in response to amyloid peptides derived from APP, and is required for both normal cell body death and axonal pruning. Trophic-factor deprivation triggers the cleavage of surface APP by beta-secretase to release sAPP-beta which is further cleaved to release an N-terminal fragment of APP (N-APP). N-APP binds TNFRSF21; this triggers caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase- 6). Negatively regulates oligodendrocyte survival, maturation and myelination. Plays a role in signaling cascades triggered by stimulation of T-cell receptors, in the adaptive immune response and in the regulation of T-cell differentiation and proliferation. Negatively regulates T-cell responses and
Subcellular Location Cell membrane {ECO:0000269|PubMed:19654028}; Single-pass type I membrane protein {ECO:0000269|PubMed:19654028}.
Tissue Specificity Detected in fetal spinal cord and in brain neurons, with higher levels in brain from Alzheimer disease patients (at protein level). Highly expressed in heart, brain, placenta, pancreas, lymph node, thymus and prostate. Detected at lower levels in lung, skeletal muscle, kidney, testis, uterus, small intestine, colon, spleen, bone marrow and fetal liver. Very low levels were found in adult liver and peripheral blood leukocytes. {ECO:0000269|PubMed:21725297, ECO:0000269|PubMed:23559013, ECO:0000269|PubMed:9714541}.
Top Pathways Cytokine-cytokine receptor interaction

Human TNFRSF21 ELISA Kit - RAB0649 from Sigma-Aldrich

Category ELISA Kit
Prices $633.00
Sizes 1 kt

Human TNFRSF21 / DR6 ELISA Kit (Custom ELISA) - LS-F341 from LifeSpan Bioscience

Category ELISA Kit
Prices $670.00, $1,190.00, $2,570.00
Sizes 1 plate, 2 plate, 5 plate
Sensitivity To be determined
Range To be determined

Human DR6/TNFRSF21 DuoSet ELISA - DY144 from R&D Systems

Category ELISA Kit
Prices $649.00
Sizes 1 kit (for 15 Plates)
Range 62.50 - 4,000 pg/mL

Tumor necrosis factor receptor superfamily member 21 (TNFRSF21), Human, ELISA Kit - CSB-EL023979HU from ARP American Research Products

Category ELISA Kit
Prices $495.00, $695.00, $696.00, $699.00
Sizes 48 t, 96 t, 5 x 96t, 10 x 96t

TNFRSF21 (Human) Matched Antibody Pair - H00027242-AP41 from Acris Antibodies

Category Antibody Pair
Prices $610.00
Sizes 1 set

Custom Human DR6 ELISA - ELH-DR6 from RayBiotech

Category ELISA Kit
Prices $615.00, $1,107.00, $2,460.00
Sizes 1 plate kit, 2 plate kit, 5 plate kit

tumor necrosis factor receptor superfamily, member 21, ELISA Kit - MBS912022 from MyBioSource

Category ELISA Kit
Prices $250.00, $495.00, $710.00, $2,705.00, $5,145.00
Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity The minimum detectable dose of human TNFRSF21 is typically less than 0.06 ng/ml.The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined the mean O.D value of 20 replicates of the zero standard added by their three standard deviations.
Range 0.25 ng/ml-16 ng/ml.

Human DR6 ELISA kit - orb78741 from Biorbyt

Category ELISA Kit
Prices $1,148.00, $1,981.00, $4,284.00
Sizes 96 well, 192 assays, 480 assays

Human Tumor necrosis factor receptor superfamily member 21 (TNFRSF21) ELISA Kit - EKC35925 from Biomatik

Category ELISA Kit
Prices $705.00, $2,820.00, $5,288.00
Sizes 96 t, 5x96t, 10x96t
Sensitivity 0.06 ng/ml
Range 16 ng/ml-0.25 ng/ml

Human DR6/TNFRSF21 ELISA Kit - NR-E10162 from Novatein Biosciences

Category ELISA Kit
Prices $532.50, $1,049.50, $1,878.90
Sizes 1x96t, 2x96t, 4x96t
Range 62.5-4000pg/ml

Custom Human DR6 ELISA - ELH-DR6-1 from RayBiotech

Category ELISA Kit
Prices $627.00, $1,128.60, $2,508.00
Sizes 1 plate kit, 2 plate kit, 5 plate kit

Human TNFRSF21 ELISA Kit - E039983 from Biobool

Category ELISA Kit
Sensitivity The minimum detectable dose of human TNFRSF21 is typically less than 0.06 ng/ml.The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined the

anti-CD358 / DR6 antibody [DR-6-04-EC] - ARG62823 from Arigo Biolaboratories

Category ELISA Kit

anti-DR6 antibody - ARG54358 from Arigo Biolaboratories

Category ELISA Kit

anti-CD358 / DR6 antibody [DR-6-04-EC] (PE) - ARG53833 from Arigo Biolaboratories

Category ELISA Kit

anti-CD358 / DR6 antibody [DR-6-04-EC] (FITC) - ARG54241 from Arigo Biolaboratories

Category ELISA Kit

Human Tumor necrosis factor receptor superfamily member 21 (TNFRSF21) ELISA Kit - AE13999HU from ARP American Research Products

Category ELISA Kit
Prices $549.00
Sizes 96 t
Sensitivity 0.056 ng/mL
Range 0.156-10 ng/mL
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