TNFRSF21

Gene Symbol	TNFRSF21
Entrez Gene	27242
Alt Symbol	BM-018, CD358, DR6
Species	Human
Gene Type	protein-coding
Description	tumor necrosis factor receptor superfamily, member 21
Other Description	TNFR-related death receptor 6|death receptor 6|tumor necrosis factor receptor superfamily member 21
Swissprots	O75509 Q96D86 Q0D2P5 B2RDI9
Accessions	CBX47587 EAX04314 EAX04315 EAX04316 EAX04317 EAX04318 O75509 AB209394 BAD92631 AF068868 AAC34583 AF208860 AAF64274 AJ420531 AK001504 BAG50928 AK025399 AK315560 BAG37936 AY358304 AAQ88671 BC005192 BC010241 AAH10241 BC015466 BC017730 AAH17730 BC021572 AAH21572 BI561782 BT007420 AAP36088 CR457190 CAG33471 DQ890769 ABM81695 DQ893930 ABM84856 DR761236 HY007775 XM_011514495 XP_011512797 NM_014452 NP_055267
Function	Promotes apoptosis, possibly via a pathway that involves the activation of NF-kappa-B. Can also promote apoptosis mediated by BAX and by the release of cytochrome c from the mitochondria into the cytoplasm. Plays a role in neuronal apoptosis, including apoptosis in response to amyloid peptides derived from APP, and is required for both normal cell body death and axonal pruning. Trophic-factor deprivation triggers the cleavage of surface APP by beta-secretase to release sAPP-beta which is further cleaved to release an N-terminal fragment of APP (N-APP). N-APP binds TNFRSF21; this triggers caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase- 6). Negatively regulates oligodendrocyte survival, maturation and myelination. Plays a role in signaling cascades triggered by stimulation of T-cell receptors, in the adaptive immune response and in the regulation of T-cell differentiation and proliferation. Negatively regulates T-cell responses and
Subcellular Location	Cell membrane {ECO:0000269|PubMed:19654028}; Single-pass type I membrane protein {ECO:0000269|PubMed:19654028}.
Tissue Specificity	Detected in fetal spinal cord and in brain neurons, with higher levels in brain from Alzheimer disease patients (at protein level). Highly expressed in heart, brain, placenta, pancreas, lymph node, thymus and prostate. Detected at lower levels in lung, skeletal muscle, kidney, testis, uterus, small intestine, colon, spleen, bone marrow and fetal liver. Very low levels were found in adult liver and peripheral blood leukocytes. {ECO:0000269|PubMed:21725297, ECO:0000269|PubMed:23559013, ECO:0000269|PubMed:9714541}.
Top Pathways	Cytokine-cytokine receptor interaction

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

DR6 CRISPR/Cas9 KO Plasmid (h) - sc-402038 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

DR6 HDR Plasmid (h) - sc-402038-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

DR6 Double Nickase Plasmid (h) - sc-402038-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

DR6 Double Nickase Plasmid (h2) - sc-402038-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

DR6 CRISPR Activation Plasmid (h) - sc-402038-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

DR6 CRISPR Activation Plasmid (h2) - sc-402038-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

DR6 Lentiviral Activation Particles (h) - sc-402038-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

DR6 Lentiviral Activation Particles (h2) - sc-402038-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

DR6 siRNA (h) - sc-35220 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

DR6 shRNA Plasmid (h) - sc-35220-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

DR6 shRNA (h) Lentiviral Particles - sc-35220-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

MISSION® esiRNA - EHU017291 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN21753 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND21753 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR09004 from Sigma-Aldrich Category miRNA Prices $350.00 Sizes hutr09004

TNFRSF21 siRNA (Human) - CRH9035 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

DR6/TNFRSF21 RNAi - H00027242-R02 from Novus Biologicals Category siRNA Prices $409.00 Sizes 20 nmol Species Reactivities Human

TNFRSF21 - MBS8213742 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human TNFRSF21 (NM_014452.3) - SHH432004 from Creative biogene Category siRNA Species Reactivities Human

shRNA set against Human TNFRSF21(NM_014452.3) - SHL085110 from Creative biogene Category siRNA Species Reactivities Human

TNFRSF21 shRNA Plasmid (Human) - CHH9035 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

TNFRSF21 miRNA 3'UTR clone - MiUTR1H-10601 from Creative biogene Species Reactivities Human

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