| Gene Symbol |
CCL21
|
| Entrez Gene |
6366
|
| Alt Symbol |
6Ckine, CKb9, ECL, SCYA21, SLC, TCA4
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
chemokine (C-C motif) ligand 21
|
| Other Description |
C-C motif chemokine 21|Efficient Chemoattractant for Lymphocytes|beta chemokine exodus-2|secondary lymphoid tissue chemokine|small inducible cytokine subfamily A (Cys-Cys), member 21
|
| Swissprots |
O00585
|
| Accessions |
AAQ13417 ABK41948 CAA06653 EAW58415 O00585 AB002409 BAA21817 AF001979 AAB86594 AK311901 BAG34842 AY358887 AAQ89246 BC027918 AAH27918 BI833188 BP331359 CR450326 CAG29322 DQ892048 ABM82974 DQ895242 ABM86168 U88320 AAB91454 XM_011518004 XP_011516306 NM_002989 NP_002980
|
| Function |
Inhibits hemopoiesis and stimulates chemotaxis. Chemotactic in vitro for thymocytes and activated T-cells, but not for B-cells, macrophages, or neutrophils. Shows preferential activity towards naive T-cells. May play a role in mediating homing of lymphocytes to secondary lymphoid organs. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4.
|
| Subcellular Location |
Secreted.
|
| Tissue Specificity |
Highly expressed in high endothelial venules of lymph nodes, spleen and appendix. Intermediate levels found in small intestine, thyroid gland and trachea. Low level expression in thymus, bone marrow, liver, and pancreas. Also found in tonsil, fetal heart and fetal spleen.
|
| Top Pathways |
Cytokine-cytokine receptor interaction, Chemokine signaling pathway
|
![Western Blot: CCL21 Overexpression Lysate (Adult Normal) [NBL1-08851] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for CCL21.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/8716_CCL21%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-08851-img0002.jpg)