CCL21

Gene Symbol CCL21
Entrez Gene 6366
Alt Symbol 6Ckine, CKb9, ECL, SCYA21, SLC, TCA4
Species Human
Gene Type protein-coding
Description chemokine (C-C motif) ligand 21
Other Description C-C motif chemokine 21|Efficient Chemoattractant for Lymphocytes|beta chemokine exodus-2|secondary lymphoid tissue chemokine|small inducible cytokine subfamily A (Cys-Cys), member 21
Swissprots O00585
Accessions AAQ13417 ABK41948 CAA06653 EAW58415 O00585 AB002409 BAA21817 AF001979 AAB86594 AK311901 BAG34842 AY358887 AAQ89246 BC027918 AAH27918 BI833188 BP331359 CR450326 CAG29322 DQ892048 ABM82974 DQ895242 ABM86168 U88320 AAB91454 XM_011518004 XP_011516306 NM_002989 NP_002980
Function Inhibits hemopoiesis and stimulates chemotaxis. Chemotactic in vitro for thymocytes and activated T-cells, but not for B-cells, macrophages, or neutrophils. Shows preferential activity towards naive T-cells. May play a role in mediating homing of lymphocytes to secondary lymphoid organs. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4.
Subcellular Location Secreted.
Tissue Specificity Highly expressed in high endothelial venules of lymph nodes, spleen and appendix. Intermediate levels found in small intestine, thyroid gland and trachea. Low level expression in thymus, bone marrow, liver, and pancreas. Also found in tonsil, fetal heart and fetal spleen.
Top Pathways Cytokine-cytokine receptor interaction, Chemokine signaling pathway

6CKine CRISPR/Cas9 KO Plasmid (h) - sc-403041 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

6CKine HDR Plasmid (h) - sc-403041-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

6CKine Double Nickase Plasmid (h) - sc-403041-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

6CKine Double Nickase Plasmid (h2) - sc-403041-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

6CKine CRISPR Activation Plasmid (h) - sc-403041-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

6CKine CRISPR Activation Plasmid (h2) - sc-403041-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

6CKine Lentiviral Activation Particles (h) - sc-403041-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

6CKine Lentiviral Activation Particles (h2) - sc-403041-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

6CKine siRNA (h) - sc-39341 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

6CKine shRNA Plasmid (h) - sc-39341-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

6CKine shRNA (h) Lentiviral Particles - sc-39341-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU012861 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN5607 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND5607 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR02880 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr02880

CCL21 siRNA (Human) - CRH4298 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

CCL21 - MBS8229502 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human CCL21(NM_002989.2) - SHG150793 from Creative biogene

Category siRNA
Species Reactivities Human

CCL21 shRNA Plasmid (Human) - CHH4298 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

CCL21 miRNA 3'UTR clone - MiUTR1H-01797 from Creative biogene

Species Reactivities Human
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