CCL21

Gene Symbol	CCL21
Entrez Gene	6366
Alt Symbol	6Ckine, CKb9, ECL, SCYA21, SLC, TCA4
Species	Human
Gene Type	protein-coding
Description	chemokine (C-C motif) ligand 21
Other Description	C-C motif chemokine 21|Efficient Chemoattractant for Lymphocytes|beta chemokine exodus-2|secondary lymphoid tissue chemokine|small inducible cytokine subfamily A (Cys-Cys), member 21
Swissprots	O00585
Accessions	AAQ13417 ABK41948 CAA06653 EAW58415 O00585 AB002409 BAA21817 AF001979 AAB86594 AK311901 BAG34842 AY358887 AAQ89246 BC027918 AAH27918 BI833188 BP331359 CR450326 CAG29322 DQ892048 ABM82974 DQ895242 ABM86168 U88320 AAB91454 XM_011518004 XP_011516306 NM_002989 NP_002980
Function	Inhibits hemopoiesis and stimulates chemotaxis. Chemotactic in vitro for thymocytes and activated T-cells, but not for B-cells, macrophages, or neutrophils. Shows preferential activity towards naive T-cells. May play a role in mediating homing of lymphocytes to secondary lymphoid organs. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4.
Subcellular Location	Secreted.
Tissue Specificity	Highly expressed in high endothelial venules of lymph nodes, spleen and appendix. Intermediate levels found in small intestine, thyroid gland and trachea. Low level expression in thymus, bone marrow, liver, and pancreas. Also found in tonsil, fetal heart and fetal spleen.
Top Pathways	Cytokine-cytokine receptor interaction, Chemokine signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active CCL21 full length protein - ab9852 from Abcam Category Protein Prices $110.00, $239.00 Sizes 5 µg, 20 µg Source E. coli

Active CCL21 full length protein - ab9904 from Abcam Category Protein Prices $110.00, $239.00 Sizes 5 µg, 20 µg Source E. coli

Active human CCL21 full length protein - ab191788 from Abcam Category Protein Prices $192.00 Sizes 20 µg Source E. coli Species Human

Active mouse Exodus 2 full length protein - ab201361 from Abcam Category Protein Prices $101.00 Sizes 5 µg Source E. coli Species Mouse

Human CCL21 full length protein - ab159489 from Abcam Category Protein Prices $402.00 Sizes 2 µg Source Wheat germ Species Human

Human CCL21 full length protein - ab193739 from Abcam Category Protein Prices $155.00 Sizes 10 µg Source Mammalian Species Human

Human CCL21 full length protein - ab195061 from Abcam Category Protein Prices $155.00 Sizes 10 µg Source Mammalian Species Human

CCL21 / SLC Antibody Blocking Peptide - LS-E64 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human CCL21/6Ckine Protein - NBP2-35002 from Novus Biologicals Category Protein Prices $69.00, $169.00, $2,669.00 Sizes 5 µg, 20 µg, 1 mg Source E. coli Species Human

CCL21/6Ckine Recombinant Protein - H00006366-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Species Human

Recombinant Human CCL21/6Ckine Protein - NBP1-37092 from Novus Biologicals Category Protein Prices $349.00, $969.00 Sizes 50 µg, 250 µg Source E. coli Species Human

CCL21/6Ckine Recombinant Protein - P3606 from Novus Biologicals Category Protein Prices $369.00 Sizes 20 µg Species Human

CCL21/6Ckine Protein - NBP1-99247 from Novus Biologicals Category Protein Prices $299.00 Sizes 20 µg Species Human

CCL21-Antibody-Center-Blocking-peptide - BP10134c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

CCL21 protein - GTX29852 from GeneTex Category Protein Prices $299.00 Sizes 20 μg Species Human

CCL21 recombinant protein - GTX65249 from GeneTex Category Protein Prices $249.00 Sizes 20 μg Source E. coli Species Human

CCL21 Recombinant Protein (Active) - GTX48365-PRO from GeneTex Category Protein Prices $299.00 Sizes 20 μg Source E. coli Species Human

Recombinant Human CCL21/6Ckine - 366-6C-025 from R&D Systems Category Protein Source E. coli-derived, Ser24-Pro134

Recombinant Human CCL21/6Ckine, CF - 366-6C-025/CF from R&D Systems Category Protein Source E. coli-derived, Ser24-Pro134

Recombinant Human CCL21/6Ckine (Mucin Stalk Chimera) - 966-6C-025 from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived

Recombinant Human CCL21/6Ckine (Mucin Stalk Chimera), CF - 966-6C-025/CF from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived

Recombinant Rat CCL21/6Ckine, CF - 7949-6C-025/CF from R&D Systems Category Protein Source E. coli-derived, Ser24-Gln133

Exodus 2 Protein (OPPA00429) - OPPA00429 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 5 µg Source E. Coli

Human CCL21 protein - orb244078 from Biorbyt Category Protein Prices $213.00, $408.00, $680.00, $1,122.00, $1,777.00 Sizes 10 μg, 50 μg, 200 μg, 500 μg, 1 mg Species Human

Human CCL21 protein - orb84574 from Biorbyt Category Protein Prices $230.00, $357.00, $570.00 Sizes 5 μg, 20 μg, 50 μg Source Insect Species Human

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