SRSF1

Gene Symbol	SRSF1
Entrez Gene	6426
Alt Symbol	ASF, SF2, SF2p33, SFRS1, SRp30a
Species	Human
Gene Type	protein-coding
Description	serine/arginine-rich splicing factor 1
Other Description	SR splicing factor 1|alternative-splicing factor 1|pre-mRNA-splicing factor SF2, P33 subunit|splicing factor 2|splicing factor, arginine/serine-rich, 30-KD, A
Swissprots	B2R6Z7 D3DTZ3 Q13809 Q07955
Accessions	EAW94485 EAW94486 EAW94487 EAW94488 EAW94489 EAW94490 EAW94491 EAW94492 Q07955 AB062124 BAB93456 AB209558 BAD92795 AK054610 AK095112 AK126318 BAC86523 AK225711 AK289933 BAF82622 AK298527 BAH12806 AK312781 BAG35644 BC010264 AAH10264 BC033785 AAH33785 CB044653 DA939911 HG509274 M69040 AAA03476 M72709 AAA35564 XM_006722012 XP_006722075 XR_429911 XR_429912 NM_001078166 NP_001071634 NM_006924 NP_008855 NR_034041
Function	Plays a role in preventing exon skipping, ensuring the accuracy of splicing and regulating alternative splicing. Interacts with other spliceosomal components, via the RS domains, to form a bridge between the 5'- and 3'-splice site binding components, U1 snRNP and U2AF. Can stimulate binding of U1 snRNP to a 5'-splice site-containing pre-mRNA. Binds to purine-rich RNA sequences, either the octamer, 5'-RGAAGAAC-3' (r=A or G) or the decamers, AGGACAGAGC/AGGACGAAGC. Binds preferentially to the 5'- CGAGGCG-3' motif in vitro. Three copies of the octamer constitute a powerful splicing enhancer in vitro, the ASF/SF2 splicing enhancer (ASE) which can specifically activate ASE-dependent splicing. Isoform ASF-2 and isoform ASF-3 act as splicing repressors. May function as export adapter involved in mRNA nuclear export through the TAP/NXF1 pathway. {ECO:0000269|PubMed:8139654}.
Subcellular Location	Cytoplasm. Nucleus speckle. Note=In nuclear speckles. Shuttles between the nucleus and the cytoplasm.
Top Pathways	Spliceosome, Herpes simplex infection

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human SRSF1 / SF2 ELISA Kit (Sandwich ELISA) - LS-F12658 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 0.312 Range 0.312-20 ng/ml

Serine/arginine-rich splicing factor 1, SRSF1, Human, ELISA Kit - E8282h from ARP American Research Products Category ELISA Kit Prices $660.00 Sizes 96 t Range 0.312-20 ng/mL

splicing factor, arginine/serine-rich 1, ELISA Kit - MBS912663 from MyBioSource Category ELISA Kit Prices $250.00, $495.00, $710.00, $2,705.00, $5,145.00 Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity <7.81 pg/ml Range 31.25 pg/ml-2000 pg/ml

Human Serine/arginine-rich splicing factor 1(SFRS1) ELISA kit - CSB-EL021142HU from Cusabio Category ELISA Kit Sensitivity 7.81 pg/ml Range Request Information

Mouse SRSF1 / SF2 ELISA Kit (Custom ELISA) - LS-F20140 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity To be determined Range 0.312-20 ng/ml

Pig SRSF1 / SF2 ELISA Kit (Custom ELISA) - LS-F20141 from LifeSpan Bioscience Category ELISA Kit Prices $700.00 Sizes 1 plate Sensitivity To be determined Range 0.312-20 ng/ml

Chicken SRSF1 / SF2 ELISA Kit (Custom ELISA) - LS-F20143 from LifeSpan Bioscience Category ELISA Kit Prices $700.00 Sizes 1 plate Sensitivity To be determined Range 0.312-20 ng/ml

Bovine SRSF1 / SF2 ELISA Kit (Custom ELISA) - LS-F20142 from LifeSpan Bioscience Category ELISA Kit Prices $700.00 Sizes 1 plate Sensitivity To be determined Range 0.312-20 ng/ml

Human Serine/arginine-rich splicing factor 1 ELISA Kit - abx251738 from Abbexa Category ELISA Kit Range 0.312 ng/ml - 20 ng/ml

Human SF2 ELISA Kit - abx570580 from Abbexa Category ELISA Kit Sensitivity 0.072 ng/ml Range 0.156 ng/ml - 10 ng/ml

Human Serine/arginine-rich splicing factor 1 (SFRS1) ELISA Kit - EKC35509 from Biomatik Category ELISA Kit Prices $705.00, $2,820.00, $5,288.00 Sizes 96 t, 5x96t, 10x96t Sensitivity 7.813 pg/ml Range 2000 pg/ml-31.25 pg/ml

Human Serine/arginine-rich splicing factor 1 ELISA Kit - EKE54458 from Biomatik Category ELISA Kit Prices $759.00, $3,225.75, $6,072.00 Sizes 96 t, 5x96t, 10x96t Sensitivity The minimum detectable dose of this kit is typically less than 0.12 ng/mL Range 0.312-20 ng/mL

SRSF1 - EKH4758 from Nordic BioSite Sensitivity 0.188ng/ml Range 0.312-20ng/ml

SRSF1 ELISA Kit (Human) : 96 Wells (OKEH01837) - OKEH01837 from Aviva Systems Biology Category ELISA Kit Prices $450.00 Sizes 96 wells Sensitivity < 0.12 ng/mL Range 0.312 - 20 ng/mL

Human SRSF1 ELISA Kit - E034756 from Biobool Category ELISA Kit Sensitivity <0.188ng/ml

Human SFRS1 ELISA Kit - E036502 from Biobool Category ELISA Kit Sensitivity 7.81 pg/ml.

Human Serine/arginine-rich splicing factor 1 ELISA Kit - EK4788 from Signalway Antibody Category ELISA Kit Prices $659.00 Sizes 1x96t Range 31.2-2000 pg/mL

Serine/arginine-rich splicing factor 1, ELISA Kit - MBS9428614 from MyBioSource Category ELISA Kit Prices $605.00 Sizes 96 tests Sensitivity Less than 0.12ng/mL Range 0.312-20 ng/mL

Serine/arginine-rich splicing factor 1, ELISA Kit - MBS289976 from MyBioSource Category ELISA Kit Prices $430.00, $570.00, $2,515.00, $4,520.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Range 0.312-20 ng/mL

Human SRSF1 / SF2 ELISA Kit (Sandwich ELISA) - LS-F34837 from LifeSpan Bioscience Category ELISA Kit Sensitivity 0.188 Range 0.312-20 ng/ml

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